Abnormal Cortical Thickness Alterations in Fetal Alcohol Spectrum Disorders and Their Relationships with Facial Dysmorphology

Yang, Yaling; Roussotte, Florence F.; Kan, Eric; Sulik, Kathleen K.; Mattson, Sarah N.; Riley, Edward P.; Jones, Kenneth Lyons; Adnams, Colleen M.; May, Philip A.; O’Connor, Mary J.; Narr, Katherine L.; Sowell, Elizabeth R.

doi:10.1093/cercor/bhr193

Cited by 102 publications

(119 citation statements)

References 85 publications

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“…For example, cortical thinning was seen in 22q11.2 deletion syndrome (36) and autism (14) and cortical thickening in fetal alcohol spectrum disorder (17) and ADHD (37) while both thinning and thickening were seen in autism (38), prematurity (15), and ADHD (16). Although it is not readily clear what accounts for this variation, even within the same disorder, this may reflect the particular analytic tool, statistical approach, or sample characteristics (e.g., age range, sex composition).…”

Section: Discussionmentioning

confidence: 99%

“…A commonly used tool is FreeSurfer Image Analysis Suite (Laboratory for Computational Neuroimaging, Martinos Center for Biomedical Imaging, Charlestown, MA), which via a set of automated algorithms, precisely reproduces gray/white and pial surfaces and measures CT by the distance between corresponding vertices on both surfaces (13). Research using this technique has shown distinct CT abnormalities in various pediatric conditions including autism (14), prematurity (15), attention deficit hyperactivity disorder (ADHD) (16), and fetal alcohol spectrum disorder (17).…”

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confidence: 99%

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Do children with congenital hypothyroidism exhibit abnormal cortical morphology?

et al. 2015

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Background: Given thyroid hormone (TH)'s essential role in multiple aspects of early brain development, children with congenital hypothyroidism (CH) detected and treated early may still display subtle cognitive and behavioral impairments as well as brain abnormalities. However, effects on their cortical development are not yet known. We used an automated neuroimaging technique to determine if these children differ in cortical thickness (CT) from typically developing controls (TDC) and if the regions showing CT differences reflect severity of initial hypothyroidism and predict later neuropsychological functioning. Methods: FreeSurfer Image Analysis Suite was used on archived MRI scans from 41 CH and 42 TDC children aged 9-16 y. Vertex-based procedures were used to compare groups and perform correlations between CT and indices of disease severity and neuropsychological outcome. results: The CH group showed multiple regions of cortical thinning or cortical thickening within right and left hemispheres relative to TDC. CT values were significantly correlated with early T4 and thyroid-stimulating hormone (TSH) levels and current neuropsychological test indices. conclusion: The developing cortex is sensitive to early TH loss in CH. Different patterns of cortical thinning or cortical thickening among brain regions may reflect timing of TH deficiency relative to timing of cortical development.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Do children with congenital hypothyroidism exhibit abnormal cortical morphology?

et al. 2015

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“…In contrast to the commonly observed reductions, some studies have reported increases in cortical thickness in children and young adults with FASD in the lateral occipital regions [39], frontal, temporal and parietal regions [40]. Gray matter density was found increased in the parietal region [41;42], unilaterally in the peri-Sylvian cortices of the temporal and parietal lobes [43], and the frontal and occipital temporal regions [42].…”

Section: Accepted Manuscriptmentioning

confidence: 98%

Radiological studies of fetal alcohol spectrum disorders in humans and animal models: An updated comprehensive review

Nguyen

Chong

Tieng

et al. 2017

Magnetic Resonance Imaging

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“…Several studies have reported increased cortical thickness in diffuse regions across the frontal, temporal, and parietal lobes [50][51][52] while another study reported cortical thinning [53]. Longitudinally, children with prenatal alcohol exposure show less developmentally appropriate cortical thinning across time compared to controls [54].…”

Section: Maternal and Environmental Variablesmentioning

confidence: 99%

Review of Current Neuroimaging Studies of the Effects of Prenatal Drug Exposure: Brain Structure and Function

Willford¹,

Smith²,

Kuhn³

et al. 2016

Recent Advances in Drug Addiction Research and Clinical Applications

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Neuroimaging tools have provided novel methods for understanding the impact of prenatal drug exposure on brain structure and function and its relation to development and behavior. Information gained from neuroimaging studies allows for the investigation of how prenatal drug exposure alters the typical developmental trajectory. The current prevalence and characteristics of prenatal drug exposure and its implications for vulnerable periods of brain development are reviewed. Structural and functional neuroimaging methods are introduced with examples of how study results from prenatal alcohol, cocaine, marijuana, and tobacco exposure further our understanding of the neurodevelopment impact of prenatal drug exposure. Prenatal drug neuroimaging studies have advanced our understanding of mechanisms and functional deficits associated with prenatal drug exposure. Studies have identified brain circuits associated with the default mode network, inhibitory control, and working memory that show differences in function as a result of prenatal drug exposure. The information gained from studies of prenatal drug exposure on brain structure and function can be used to make connections between animal models and human studies of prenatal drug exposure, identify biomarkers of documented effects of prenatal drug exposure on behavior, and inform prevention and intervention programs for young children.

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Abnormal Cortical Thickness Alterations in Fetal Alcohol Spectrum Disorders and Their Relationships with Facial Dysmorphology

Cited by 102 publications

References 85 publications

Do children with congenital hypothyroidism exhibit abnormal cortical morphology?

Do children with congenital hypothyroidism exhibit abnormal cortical morphology?

Radiological studies of fetal alcohol spectrum disorders in humans and animal models: An updated comprehensive review

Review of Current Neuroimaging Studies of the Effects of Prenatal Drug Exposure: Brain Structure and Function

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