Abnormal degree centrality in Alzheimer's disease patients with depression: A resting-state functional magnetic resonance imaging study

Guo, Zhongwei; Liu, Xiaozheng; Hou, Hongyan; Wei, Fuquan; Jian, Liu; Chen, Xingli

doi:10.1016/j.exger.2016.03.017

Cited by 75 publications

(49 citation statements)

References 44 publications

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“…Increased voxel-wise DC in a brain region indicates an elevated degree of its global connectivity, and decreased voxelwise DC in a brain region suggests a reduced degree of its global connectivity. Voxel-wise DC has been applied to reveal the abnormal brain networks in various types of neurological or psychiatric diseases (16)(17)(18)(19)(20)(21)(22). This method has also been used to compare the brain network features of different psychiatric diseases with potentially similar neural pathology, such as autism and attention-deficit hyperactivity disorder (23), or to examine the brain-network difference between the subtypes of a disease such as the Parkinson's disease patients with depression and those without depression (24).…”

Section: Introductionmentioning

confidence: 99%

Abnormal Voxel-Wise Degree Centrality in Patients With Late-Life Depression: A Resting-State Functional Magnetic Resonance Imaging Study

Gong

et al. 2020

Front. Psychiatry

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Objectives: Late-life depression (LLD) has negative impacts on somatic, emotional and cognitive domains of the lives of patients. Elucidating the abnormality in the brain networks of LLD patients could help to strengthen the understanding of LLD pathophysiology, however, the studies exploring the spontaneous brain activity in LLD during the resting state remain limited. This study aimed at identifying the voxel-level whole-brain functional connectivity changes in LLD patients. Methods: Fifty patients with late-life depression (LLD) and 33 healthy controls were recruited. All participants underwent a resting-state functional magnetic resonance imaging scan to assess the voxel-wise degree centrality (DC) changes in the patients. Furthermore, DC was compared between two patient subgroups, the late-onset depression (LOD) and the early-onset depression (EOD). Results: Compared with the healthy controls, LLD patients showed increased DC in the inferior parietal lobule, parahippocampal gyrus, brainstem and cerebellum (p < 0.05, AlphaSim-corrected). LLD patients also showed decreased DC in the somatosensory and motor cortices and cerebellum (p < 0.05, AlphaSim-corrected). Compared with EOD patients, LOD patients showed increased centrality in the superior and middle temporal gyrus and decreased centrality in the occipital region (p < 0.05, AlphaSim-corrected). No significant correlation was found between the DC value and the symptom severity or disease duration in the patients after the correction for multiple comparisons. Conclusions: These findings indicate that the intrinsic abnormality of network centrality exists in a wide range of brain areas in LLD patients. LOD patients differ with EOD patients

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Section: Introductionmentioning

confidence: 99%

Abnormal Voxel-Wise Degree Centrality in Patients With Late-Life Depression: A Resting-State Functional Magnetic Resonance Imaging Study

Gong

et al. 2020

Front. Psychiatry

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“…IBA involves dynamic neural and metabolic activities, it is activity and plays a pivotal role in brain function (Dai and He, 2014;Raichle, 2015). These methods have been widely used to evaluate the IBA of neurological disorders or neuropsychiatric disorders, such as AD, depression, and MCI (Yao et al, 2009;Zhang et al, 2012;Guo et al, 2016;Wee et al, 2016;Stoyanov et al, 2017;Zhang et al, 2017;Kandilarova et al, 2018;Yang et al, 2018;Liu et al, 2019). Furthermore, evidence indicated that once brain got an internal or external stimuli, it could respond by dynamic integration or adjustment over multiple time scales (Hutchison et al, 2013;Bassett and Sporns, 2017;Yan et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Depression Affects Intrinsic Brain Activity in Patients With Mild Cognitive Impairment

Lin

et al. 2019

Front. Neurosci.

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Numerous observational studies have shown that depressive symptoms are common in individuals with mild cognitive impairment (MCI) who have a higher rate of progress to dementia. However, it is still uncertain whether there are any differences between MCI patients with and without depression symptom in their brain function activities. Here we have identified the brain function activity differences in two groups of MCI patients (with depression or without depression) using the resting state MRI (rsfMRI) measurements. 76 right-handed MCI subjects have been recruited in this study, including 27 MCI patients with depression symptom (MCID), 49 MCI patients without depression symptom (MCIND). Analyses based on 7 rsfMRI measurements, including four static measurements (ALFF, fALFF, PerAF, and ReHo) and three dynamic measurements (dALFF, dfALFF, and dReHo) have been used to explore the temporal variability of intrinsic brain activity. No significant differences in ALFF and dALFF between the two group were found. In the MCID group, fALFF decreased in temporal gyrus, frontal gyrus, inferior occipital gyrus, middle frontal gyrus and cerebellum, but increased in cuneus, calcarine, lingual; while PerAF increased in left parahippocampus. The differences of ReHo in the two groups was only found in cerebellum. Compared to MCIND group, dfALFF in MCID decreased in cuneus, occipital gyrus and calcarine, while dReHo in MCID increased in bilateral temporal gyrus, frontal gyrus, superior parietal gyrus, inferior parietal gyrus and precuneus. Our results may provide a better understanding in the relationship between the depressive symptoms and memory deficits.

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“…Previous studies have also confirmed that DC has a high sensitivity, specificity, and test-retest reliability, (Zuo and Xing 2014) and it has been increasingly used in many disorders associated with cognitive impairment, such as obstructive sleep apnea, diabetes, Parkinson's, and Alzheimer's disease. (Li et al 2016;Liu et al 2018;Wang et al 2018;Guo et al 2016) Therefore, the voxel-wise DC can help us investigate the intrinsic function hubs that may be associated with cognitive impairment in COPD.…”

Section: Introductionmentioning

confidence: 99%

Abnormal intrinsic functional hubs and connectivity in stable patients with COPD: a resting-state MRI study

Xin

et al. 2019

Brain Imaging and Behavior

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Chronic obstructive pulmonary disease (COPD) affects a large population and is closely associated with cognitive impairment. However, the mechanisms of cognitive impairment in COPD patients have not been unraveled. This study investigated the change in patterns of intrinsic functional hubs using a degree centrality (DC) analysis. The connectivity between these abnormal hubs with the remaining brain was also investigated using functional connectivity (FC). Nineteen stable patients with COPD and 20 normal controls(NC) underwent functional magnetic resonance imaging (MRI) examinations and clinical and neuropsychologic assessments. We measured the voxel-wise DC across the whole brain gray matter and the seed-based FC between these abnormal hubs in the remaining brain matter; the group difference was calculated. A partial correlation analysis was performed to assess the relationship between the abnormal DC and clinical variables in COPD patients. Compared to NC, the patients with COPD exhibited significantly decreased DC in the right lingual gyrus (LG), bilateral supplementary motor area (SMA), and right paracentral lobule (PCL). A further seed-based FC analysis found that COPD patients demonstrated significantly decreased FC between these abnormal hubs in several brain areas, including the left cerebellum anterior lobe, left lingual gyrus, left fusiform gyrus, right insula, right inferior frontal gyrus, limbic lobe, cingulate gyrus, left putamen, lentiform nucleus, right precuneus, and right paracentral lobule. A partial correlation analysis showed that the decreased DC in the right PCL was positively correlated with the FEV1 and FEV1/FVC, and the decreased DC in the SMA was positively correlated with naming and pH in COPD patients. This study demonstrates that there are intrinsic functional hubs and connectivity alterations that may reflect the aberrant information communication in the brain of COPD patients. These findings may help provide new insight for understanding the mechanisms of COPD-related cognitive impairment from whole brain functional connections.

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Abnormal degree centrality in Alzheimer's disease patients with depression: A resting-state functional magnetic resonance imaging study

Cited by 75 publications

References 44 publications

Abnormal Voxel-Wise Degree Centrality in Patients With Late-Life Depression: A Resting-State Functional Magnetic Resonance Imaging Study

Abnormal Voxel-Wise Degree Centrality in Patients With Late-Life Depression: A Resting-State Functional Magnetic Resonance Imaging Study

Depression Affects Intrinsic Brain Activity in Patients With Mild Cognitive Impairment

Abnormal intrinsic functional hubs and connectivity in stable patients with COPD: a resting-state MRI study

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