Abnormal Elastic Fibers in Elastosis of Breast Carcinoma UItrastructuraI and ImmunohistochemicaI Studies

Uchiyama, Shouichi; Fukuda, Yuh

doi:10.1111/j.1440-1827.1989.tb01508.x

Cited by 8 publications

(8 citation statements)

References 17 publications

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“…These findings suggest that MPD strictures are not always provoked by destruction or filling with cancer cells. The elastosis observed here resembles the periductal elastosis seen in scirrhous‐type ductal carcinoma of the breast and, 12 while the underlying mechanisms remain unknown, it might be considered part of the desmoplastic stromal reaction to carcinoma cells. In the normal pancreas, myofibroblasts exist mainly in the outer region of the MPD wall where they regulate intraductal pressure 13 but, in this case, no myofibroblasts were found in the wall of the stenotic MPD, whereas fibroblasts had proliferated.…”

Section: Discussionmentioning

confidence: 53%

Minute pancreatic adenocarcinoma presenting with stenosis of the main pancreatic duct

Yachida

Fukushima

Nakanishi³

et al. 2002

Pathology International

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We describe a case of minute pancreatic ductal adenocarcinoma featuring stenosis of the main pancreatic duct (MPD) and associated with histological findings of periductal elastosis and fibroblast proliferation. A 53-year-old Japanese man with preoperative radiological evidence of MPD stricture and dilation of the distal MPD, and suspected of having pancreatic cancer, underwent successful resection. Neither radiological nor macroscopic examination directly disclosed any tumorous lesions, and a small focus of carcinoma (8 x 8 mm) was only revealed on microscopic examination. The tumor was a poorly differentiated, invasive ductal adenocarcinoma that had invaded the intrapancreatic nerves and veins. Interestingly, the MPD located at the edges of the tumor had not been destroyed by the carcinoma, but its wall had been thickened by elastic tissue and fibroblast proliferation, resulting in stenosis. The peripheral pancreas exhibited secondary obstructive pancreatitis. To date, the detection of small pancreatic tumor masses using imaging procedures remains difficult, and most patients are diagnosed on the basis of pancreatic ductal changes. However, the published work on small pancreatic cancers contains little information about the histological features of the affected MPD. The present findings suggest that MPD strictures are not always provoked by destruction or filling with cancer cells, and that they can be caused by periductal elastosis and fibroblast proliferation in a minute carcinoma. Such changes in the MPD may therefore be of clinical importance in the detection of early stage cancers.

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Section: Discussionmentioning

confidence: 53%

Minute pancreatic adenocarcinoma presenting with stenosis of the main pancreatic duct

Yachida

Fukushima

Nakanishi³

et al. 2002

Pathology International

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“…As a component of vasculature and ECM in normal stroma, elastin exhibited changes associated with the neoplastic process. Uchiyama et al identified ‘breast cancer elastosis’ as condensed accumulations of irregularly arranged small amorphous elastin components associated with only a few microfibrils . These amorphous components were ill‐defined and occasionally associated with spiraling collagen fibrils and cellular debris.…”

Section: Discussionmentioning

confidence: 99%

ColXα1 is a stromal component that colocalizes with elastin in the breast tumor extracellular matrix

Wang

Xiong

et al. 2018

The Journal of Pathology CR

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The tumor microenvironment regulates tissue development and homeostasis, and its dysregulation contributes to neoplastic progression. Increased expression of type X collagen α-1 (ColXα1) in tumor-associated stroma correlates with poor pathologic response to neoadjuvant chemotherapy in estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2)-positive breast cancers. Evaluation of ColXα1 expression patterns suggests a potential connection with elastin fibers. To investigate the possible interaction between ColXα1 and elastin, we evaluated the expression of ColXα1 in relation to elastin fibers in normal breast tissue, ductal carcinoma in situ, and invasive breast carcinomas at cellular and subcellular levels. Our findings demonstrate that ColXα1 colocalizes with elastin in invasive breast cancer-associated stroma by immunohistochemistry, immunofluorescence, and electron microscopy. In 212 invasive breast carcinomas, this complex was aberrantly and selectively expressed in tumor extracellular matrix in 79% of ER+/HER2-, 80% of ER+/HER2+, 76% of ER-/HER2+, and 58% of triple negative breast cancers. In contrast, ColXα1 was generally absent, while elastin was present perivascularly in normal breast tissue. ColXα1 and elastin were coexpressed in 58% of ductal carcinoma in situ (DCIS) in periductal areas. In mass-forming DCIS with desmoplastic stroma, the complex was intensely expressed in periductal areas as well as within the tumor-associated stroma in all cases. Our data suggest that the breast carcinoma neoplastic process may involve aberrant expression of ColXα1 and elastin in the tumor microenvironment emerging early at the DCIS stage. Enrichment of these complexes in tumor-associated stroma may represent a stromal signature indicative of intrinsic differences between breast cancers. These findings shed light on investigation into the role of aberrant collagen complex expression in tumorigenesis and tumor progression which may be leveraged in therapeutic and theranostic applications.

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“…[1][2][3][4][5][6][7][8][9][10][11][12] However, in the breast, not only blood vessels but also mammary ducts are often coated by elastic fibers, and the presence of tumor cells in an elastic ring does not always indicate BVI: it could be a ductal carcinoma in situ (DCIS) component, which is often left within invasive carcinoma. [13][14][15][16] This makes the evaluation of BVI difficult. 17,18 Various criteria, such as focusing just on peritumor areas or lesions in one of paired vessels, have been introduced to avoid mistaking DCIS components as BVI.…”

Section: Introductionmentioning

confidence: 99%

Elastin and collagen IV double staining: A refined method to detect blood vessel invasion in breast cancer

Fujisawa

Omori

Doihara

et al. 2020

Pathology International

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Blood vessel invasion (BVI) is a prognostic indicator in various cancers. Elastic stain, which highlights blood vessel walls, is commonly used to detect BVI. In the breast, however, its diagnostic usefulness is limited because it also highlights some intraductal carcinoma components, which often mimic BVI. In this study, we aimed to improve BVI detection in breast cancer and developed a double staining: Victoria blue for elastin and immunohistochemistry for collagen IV. Collagen IV fibers were retained along the basement membranes of intraductal carcinoma components, whereas they were rearranged or lost in BVI. From these observations, we defined BVI as the presence of tumor cells inside an elastic ring with a rearrangement or loss of collagen IV fibers. Using these criteria, we found BVI in 148 cases (49%) among 304 cases of primary operable invasive breast carcinoma, and the presence of BVI correlated significantly with poor prognosis. By contrast, we detected BVI in 94 cases (31%) or 14 cases (5%) by elastic van Gieson or CD31 immunostaining among the same cases, respectively, with no statistically significant association with prognosis. Thus, elastin and collagen IV double staining facilitates the detection of BVI in breast cancer and is useful to predict prognosis.

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Abnormal Elastic Fibers in Elastosis of Breast Carcinoma UItrastructuraI and ImmunohistochemicaI Studies

Cited by 8 publications

References 17 publications

Minute pancreatic adenocarcinoma presenting with stenosis of the main pancreatic duct

Minute pancreatic adenocarcinoma presenting with stenosis of the main pancreatic duct

ColXα1 is a stromal component that colocalizes with elastin in the breast tumor extracellular matrix

Elastin and collagen IV double staining: A refined method to detect blood vessel invasion in breast cancer

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