Abnormal Expression of p16<sup>INK4a</sup>, Cyclin D1, Cyclin‐Dependent Kinase 4 and Retinoblastoma Protein in Gastric Carcinomas

Kishimoto, Ichiro; Mitomi, Hiroyuki; Ohkura, Yasuo; Kanazawa, Hideki; Fukui, Naoshi; Watanabe, Masahiko

doi:10.1002/jso.21087

Cited by 40 publications

(41 citation statements)

References 33 publications

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“…We did not identify a statistical correlation between the presence of lymph node involvement and the immunohistochemical expression of p16 ink4a . This is a conflicting result compared with previous reports (30,31). Although the expression of p16 ink4a is altered in gastric tumors, this alteration is considered to be secondary to p53 mutations (5).…”

Section: Kip1contrasting

confidence: 62%

Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma

et al. 2017

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Abstract.wafl/cip1 was positive in 32.4, 72.7 and 71.4% of the cases, respectively. All the tumors were positive for p53. Tumors with lymph node invasion presented with overexpression (+4) of p53 in 47% of the cases vs. 17% of patients who did not have lymph node involvement. Therefore, higher expression of p53, p21 ras and p21 wafl/cip1 in the tumor exhibited a statistically significant association with lymph node involvement.

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Section: Kip1contrasting

confidence: 62%

Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma

et al. 2017

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“…Inactivation of P16 leads to excessive proliferation of cells. Kishimoto et al (2008) found that there are at least more than 2 abnormal expression of oncogene in the development of gastric cancer. Nearly 40%-50% cases were occurred in the absence of expression of P16/Rb and overexpress of CyclinD1/CDK4.…”

Section: Discussionmentioning

confidence: 99%

Anti-Proliferation Effects and Molecular Mechanisms of Action of Tetramethypyrazine on Human SGC-7901 Gastric Carcinoma Cells

Ji¹,

Liu²,

Ju³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…This was also supported by the observation that TRIM24 knockdown decreased the expression levels of the Wnt/β-catenin target genes, β-catenin, cyclinD1 and c-Myc. CyclinD1 is overexpressed in several types of cancer and serves as a regulator of cell cycle progression through the G1/S checkpoint (32)(33)(34). c-Myc is a nuclear phosphoprotein, which regulates the cell cycle and apoptosis (35).…”

Section: A B C D E Fmentioning

confidence: 99%

TRIM24 promotes the aggression of gastric cancer via the Wnt/β-catenin signaling pathway

et al. 2017

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Abstract. Tripartite motif-containing 24 (TRIM24) is important in tumor development and progression. However, the role of TRIM24 in gastric cancer (GC) and the mechanisms underlying the dysregulated expression of TRIM24 remain to be fully elucidated. In the present study, it was found that TRIM24 was frequently overexpressed in GC cell lines and tissues compared with normal controls, as determined by western blotting and immunohistochemical staining. The high nuclear expression of TRIM24 was correlated with the depth of invasion (P=0.007), tumor-node-metastasis stage (P=0.005), and lymph node metastasis (P=0.027), and shorter overall survival rates (P=0.010) in patients with GC. Small interfering RNA-mediated knockdown of TRIM24 inhibited cell proliferation, colony formation, migration, invasion and the nuclear accumulation of β-catenin, and it delayed cell cycle progression and induced apoptosis. In addition, the expression of TRIM24 was positively correlated with that of β-catenin in GC tissues. TRIM24 knockdown decreased the expression of Wnt/β-catenin target genes, whereas the activation of Wnt/β-catenin signaling by lithium chloride reversed the effects of TRIM24 knockdown. Taken together, these data suggested that TRIM24 was a prognostic or potential therapeutic target for patients with GC and was important in the activation of the Wnt/β-catenin pathway during the progression of GC.

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Abnormal Expression of p16^INK4a, Cyclin D1, Cyclin‐Dependent Kinase 4 and Retinoblastoma Protein in Gastric Carcinomas

Abstract: The Rb pathway is disrupted in the vast majority of gastric carcinomas. This study also identified specific immunohistochemical marker profiles for prognosis.

Cited by 40 publications

References 33 publications

Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma

Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma

Anti-Proliferation Effects and Molecular Mechanisms of Action of Tetramethypyrazine on Human SGC-7901 Gastric Carcinoma Cells

TRIM24 promotes the aggression of gastric cancer via the Wnt/β-catenin signaling pathway

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Abnormal Expression of p16INK4a, Cyclin D1, Cyclin‐Dependent Kinase 4 and Retinoblastoma Protein in Gastric Carcinomas

Abstract: The Rb pathway is disrupted in the vast majority of gastric carcinomas. This study also identified specific immunohistochemical marker profiles for prognosis.

Cited by 40 publications

References 33 publications

Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma

Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma

Anti-Proliferation Effects and Molecular Mechanisms of Action of Tetramethypyrazine on Human SGC-7901 Gastric Carcinoma Cells

TRIM24 promotes the aggression of gastric cancer via the Wnt/β-catenin signaling pathway

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Abnormal Expression of p16^INK4a, Cyclin D1, Cyclin‐Dependent Kinase 4 and Retinoblastoma Protein in Gastric Carcinomas