Abnormal frontostriatal activity in recently abstinent cocaine users during implicit moral processing

Caldwell, Brendan M.; Harenski, Carla L.; Harenski, Keith A.; Fede, Samantha J.; Steele, Vaughn R.; Koenigs, Michael; Kiehl, Kent A.

doi:10.3389/fnhum.2015.00565

Cited by 18 publications

(9 citation statements)

References 155 publications

(183 reference statements)

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“…Significant brain effects at the whole-brain level were found in 95% of studies. Independent of the task (passive viewing, non-emotional or emotional) and valence of the stimuli (pleasant or unpleasant), studies consistently reported a downregulation of the reward (ventral striatum, rACC/sgACC, dmPFC, OFC and aPFC) , salience (anterior insula, dACC, IPL) and executive (vlPFC/dlPFC) networks during social-emotional processing, often accompanied by reduced recruitment of the memory (hippocampus/parahippocampus) and self-directed (PCC/precuneus) networks (Asensio et al, 2010; Caldwell et al, 2015; Canterberry et al, 2016; Costumero et al, 2017; Gilman et al, 2010; Hong et al, 2017; Kim et al, 2014; Landi et al, 2011; Maurage et al, 2012; Payer et al, 2012, 2011; Roberts and Garavan, 2013; Seo et al, 2013; Wesley et al, 2016; Suppl. Table 1, Figure 4d).…”

Section: Resultsmentioning

confidence: 99%

“…Table 1, Figure 4d). Well-controlled studies using narrow contrasts and active task paradigms (Caldwell et al, 2015; Maurage et al, 2012) or highly salient stimuli (e.g., infant cries or erotic stimuli: Costumero et al, 2017; Landi et al, 2011) generally showed the most extensive effects implicating several brain networks. Compared to nicotine/cocaine addiction, brain effects in alcohol/cannabis addiction were somewhat less extensive, with specifically the reward network being less consistently implicated (Suppl.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review

Zilverstand

Huang

Alia‐Klein

et al. 2018

Neuron

410

389

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The impaired response inhibition and salience attribution (iRISA) model proposes that impaired response inhibition and salience attribution underlie drug seeking and taking. To update this model, we systematically reviewed 105 task-related neuroimaging studies (n > 15/group) published since 2010. Results demonstrate specific impairments within six large-scale brain networks (reward, habit, salience, executive, memory, and self-directed networks) during drug cue exposure, decision making, inhibitory control, and social-emotional processing. Addicted individuals demonstrated increased recruitment of these networks during drug-related processing but a blunted response during non-drug-related processing, with the same networks also being implicated during resting state. Associations with real-life drug use, relapse, therapeutic interventions, and the relevance to initiation of drug use during adolescence support the clinical relevance of the results. Whereas the salience and executive networks showed impairments throughout the addiction cycle, the reward network was dysregulated at later stages of abuse. Effects were similar in alcohol, cannabis, and stimulant addiction.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review

Zilverstand

Huang

Alia‐Klein

et al. 2018

Neuron

410

389

View full text Add to dashboard Cite

show abstract

“…Together, these and many other studies highlighted changes in functional connectivity during resting or task challenges in cocaine misuse ( Adinoff et al, 2015 ; Albein-Urios et al, 2014 ; Barros-Loscertales et al, 2011 ; Caldwell et al, 2015 ; Cisler et al, 2013 ; Hu et al, 2015c ; Konova et al, 2015 ; Ma et al, 2014 ; McHugh et al, 2014 ; Ray et al, 2015a ; Wisner et al, 2013 ; Zhang et al, 2014 ). The great majority of these studies focused on specific regions of interest, and none examined the dynamic aspects of functional connectivity ( Cohen, 2017 ).…”

Section: Introductionmentioning

confidence: 68%

Dynamic network dysfunction in cocaine dependence: Graph theoretical metrics and stop signal reaction time

Zhang

Ide

et al. 2018

NeuroImage: Clinical

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Graphic theoretical metrics have become increasingly popular in characterizing functional connectivity of neural networks and how network connectivity is compromised in neuropsychiatric illnesses. Here, we add to this literature by describing dynamic network connectivities of 78 cocaine dependent (CD) and 85 non-drug using healthy control (HC) participants who underwent fMRI during performance of a stop signal task (SST). Compared to HC, CD showed prolonged stop signal reaction time (SSRT), consistent with deficits in response inhibition. In graph theoretical analysis of dynamic functional connectivity, we examined temporal flexibility and spatiotemporal diversity of 14 networks covering the whole brain. Temporal flexibility quantifies how frequently a brain region interacts with regions of other communities across time, with high temporal flexibility indicating that a region interacts predominantly with regions outside its own community. Spatiotemporal diversity quantifies how uniformly a brain region interacts with regions in other communities over time, with high spatiotemporal diversity indicating that the interactions are more evenly distributed across communities. Compared to HC, CD exhibited decreased temporal flexibility and increased spatiotemporal diversity in the great majority of neural networks. The graph metric measures of the default mode network negatively correlated with SSRT in CD but not HC. The findings are consistent with diminished temporal flexibility and a compensatory increase in spatiotemporal diversity, in association with impairment of a critical executive function, in cocaine addiction. More broadly, the findings suggest that graph theoretical metrics provide new insights for connectivity analyses to elucidate network dysfunction that may elude conventional measures.

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“…In one study, cocaine users who were participating in an inpatient treatment program, relative to non-cocaine users, showed lower task related activity in the dorsal ACC while evaluating moral dilemmas (Verdejo-Garcia et al 2014). Additionally, in previous work we found that abstinent, incarcerated cocaine-users, relative to non-using incarcerated controls, had lower activation in the ACC and vmPFC during implicit moral processing (Caldwell et al 2015). Implicit moral processing triggers automatic moral processes but does not have moral task demands (e.g., shows a picture of a murder scene and asks if the scene is inside or outside.)…”

mentioning

confidence: 67%

“…Only two studies to date have directly examined how stimulant users’ brains process morally-salient stimuli (Caldwell et al 2015; Verdejo-Garcia et al 2014). In one study, cocaine users who were participating in an inpatient treatment program, relative to non-cocaine users, showed lower task related activity in the dorsal ACC while evaluating moral dilemmas (Verdejo-Garcia et al 2014).…”

mentioning

confidence: 99%

Abnormal fronto-limbic engagement in incarcerated stimulant users during moral processing

Fede¹,

Harenski

Borg

et al. 2016

Psychopharmacology

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Rationale Stimulant use is a significant and prevalent problem, particularly in criminal populations. Previous studies found that cocaine and methamphetamine use is related to impairment in identifying emotions and empathy. Stimulant users also have abnormal neural structure and function of the ventromedial prefrontal cortex (vmPFC), amygdala, anterior (ACC) and posterior cingulate (PCC), regions implicated in moral decision making. However, no research has studied the neural correlates of stimulant use and explicit moral processing in an incarcerated population. Objectives Here we examine how stimulant use affects sociomoral processing that might contribute to antisocial behavior. We predicted that vmPFC, amygdala, PCC, and ACC would show abnormal neural response during a moral processing task in incarcerated methamphetamine and cocaine users. Methods Incarcerated adult males (N = 211) were scanned with a Mobile MRI system while completing a moral decision making task. Lifetime drug use was assessed. Neural responses during moral processing were compared between users and non-users. The relationship between duration of use and neural function was also examined. Results Incarcerated stimulant users showed less amygdala engagement than non-users during moral processing. Duration of stimulant use was negatively associated with activity in ACC and positively associated with vmPFC response during moral processing. Conclusions These results suggest a dynamic pattern of fronto-limbic moral processing related to stimulant use with deficits in both central motive and cognitive integration elements of biological moral processes theory. This increases our understanding of how drug use relates to moral processing in the brain in an ultra-high risk population.

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Abnormal frontostriatal activity in recently abstinent cocaine users during implicit moral processing

Cited by 18 publications

References 155 publications

Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review

Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review

Dynamic network dysfunction in cocaine dependence: Graph theoretical metrics and stop signal reaction time

Abnormal fronto-limbic engagement in incarcerated stimulant users during moral processing

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