Abnormal glucose metabolism in virus associated sepsis

Zhang, Peng; Pan, Shangwen; Yuan, Shiying; Shang, You; Shu, Huaqing

doi:10.3389/fcimb.2023.1120769

Cited by 4 publications

(2 citation statements)

References 78 publications

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“…Metabolic reprogramming is a crucial process that fuels overactive immune cells [ 29 ]. In the case of severe viral infection and the so-called “cytokine storm”, a potentially life-threatening process, glycolysis plays a crucial role in the hyper-inflammatory response [ 30 ]. The ability to modulate the glycolysis process (to inhibit or stimulate its processing) could be useful for immune response control in various physiological states.…”

Section: Hyper-inflammatory Response—the Potential Of Glycolysis Inhi...mentioning

confidence: 99%

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The Impact of Glycolysis and Its Inhibitors on the Immune Response to Inflammation and Autoimmunity

Pająk,

Zieliński,

Priebe

2024

Molecules

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Glucose metabolism is a crucial biological pathway maintaining the activation of extra- and intracellular signaling pathways involved in the immune response. Immune cell stimulation via various environmental factors results in their activation and metabolic reprogramming to aerobic glycolysis. Different immune cells exhibit cell-type-specific metabolic patterns when performing their biological functions. Numerous published studies have shed more light on the importance of metabolic reprogramming in the immune system. Moreover, this knowledge is crucial for revealing new ways to target inflammatory pathologic states, such as autoimmunity and hyperinflammation. Here, we discuss the role of glycolysis in immune cell activity in physiological and pathological conditions, and the potential use of inhibitors of glycolysis for disease treatment.

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Section: Hyper-inflammatory Response—the Potential Of Glycolysis Inhi...mentioning

confidence: 99%

“…One of the most broadly tested glycolysis inhibitors is D-glucose analog 2-deoxy-D-glucose (2-DG), lacking the -OH group in the C-2 position in the pyranose ring [ 30 ]. 2-DG competes with glucose to bind to transmembrane GLUTs and enter cells.…”

Section: 2-deoxy-d-glucose As An Anti-inflammatory Agentmentioning

confidence: 99%

The Impact of Glycolysis and Its Inhibitors on the Immune Response to Inflammation and Autoimmunity

Pająk,

Zieliński,

Priebe

2024

Molecules

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Impact of the triglyceride-glucose index on 28-day mortality in non-diabetic critically Ill patients with sepsis: a retrospective cohort analysis

Zhang,

Fan,

Wang

et al. 2024

BMC Infect Dis

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Introduction Sepsis is a life-threatening condition that poses a globally high mortality rate. Identifying risk factors is crucial. Insulin resistance and the TYG index, associated with metabolic disorders, may play a role. This study explores their correlation with mortality in non-diabetic septic patients. Methods This retrospective cohort study used data from the MIMIC-IV (version 2.1) database, which includes over 50,000 ICU admissions from 2008 to 2019 at Beth Israel Deaconess Medical Center in Boston. We included adult patients with sepsis who were admitted to the intensive care unit in the study. The primary outcome was to evaluate the ability of TYG to predict death at 28-day of hospital admission in patients with sepsis. Results The study included 2213 patients with sepsis, among whom 549 (24.8%) died within 28 days of hospital admission. We observed a non-linear association between TYG and the risk of mortality. Compared to the reference group (lower TYG subgroup), the 28-day mortality increased in the higher TYG subgroup, with a fully adjusted hazard ratio of 2.68 (95% CI: 2.14 to 3.36). The area under the curve (AUC) for TYG was 67.7%, higher than for triglycerides alone (AUC = 64.1%), blood glucose (AUC = 62.4%), and GCS (AUC = 63.6%), and comparable to SOFA (AUC = 69.3%). The final subgroup analysis showed no significant interaction between TYG and each subgroup except for the COPD subgroup (interaction P -values: 0.076–0.548). Conclusion In our study, TYG can be used as an independent predictor for all-cause mortality due to sepsis within 28 days of hospitalization. Supplementary Information The online version contains supplementary material available at 10.1186/s12879-024-09711-4.

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The impact of glucose metabolism on inflammatory processes in sepsis-induced acute lung injury

Cheng,

Li,

Sun

et al. 2024

Front. Immunol.

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Acute lung injury (ALI) is a prevalent and critical complication of sepsis, marked by high incidence and mortality rates, with its pathogenesis still not being fully elucidated. Recent research has revealed a significant correlation between the metabolic reprogramming of glucose and sepsis-associated ALI (S-ALI). Throughout the course of S-ALI, immune cells, including macrophages and dendritic cells, undergo metabolic shifts to accommodate the intricate demands of immune function that emerge as sepsis advances. Indeed, glucose metabolic reprogramming in S-ALI serves as a double-edged sword, fueling inflammatory immune responses in the initial stages and subsequently initiating anti-inflammatory responses as the disease evolves. In this review, we delineate the current research progress concerning the pathogenic mechanisms linked to glucose metabolic reprogramming in S-ALI, with a focus on the pertinent immune cells implicated. We encapsulate the impact of glucose metabolic reprogramming on the onset, progression, and prognosis of S-ALI. Ultimately, by examining key regulatory factors within metabolic intermediates and enzymes, We have identified potential therapeutic targets linked to metabolic reprogramming, striving to tackle the inherent challenges in diagnosing and treating Severe Acute Lung Injury (S-ALI) with greater efficacy.

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Abnormal glucose metabolism in virus associated sepsis

Cited by 4 publications

References 78 publications

The Impact of Glycolysis and Its Inhibitors on the Immune Response to Inflammation and Autoimmunity

The Impact of Glycolysis and Its Inhibitors on the Immune Response to Inflammation and Autoimmunity

Impact of the triglyceride-glucose index on 28-day mortality in non-diabetic critically Ill patients with sepsis: a retrospective cohort analysis

The impact of glucose metabolism on inflammatory processes in sepsis-induced acute lung injury

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