Abnormal hemoglobins in mauritius Island

Kotea, Navaratnam; Ducrocq, Rolande; Surrun, Soondal Koomar; R, Ramaswamy; Shun, Nathalie Kok; Jankee, S.; Yan, Solange Lee Kwai; Beesoon, Sanjay; Labie, Dominique; Krishnamoorthy, Rajagopal; Nagel, Ronald L.; Baligadoo, S

doi:10.1002/ajh.2830480424

Cited by 2 publications

(3 citation statements)

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“…For example, the prevalence of thalassemias may vary or there may be differences in iron metabolism between the ethnic groups (19). The prevalence of the β-thalassaemia trait on the main island of Mauritius has been reported as 4.0% among Indians and 2.2% among Africans (9). To our knowledge, no information on the prevalence of Hb disorders in Rodrigues has been published.…”

Section: Discussionmentioning

confidence: 99%

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Glucose-Independent Ethnic Differences in HbA1c in People Without Known Diabetes

et al. 2013

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OBJECTIVETo determine whether glucose-independent differences in HbA1c exist between people of African, South Asian, and Chinese ethnicities.RESEARCH DESIGN AND METHODSData from 6,701 people aged 19–78 years, without known diabetes, from Mauritius, and participating in the population-based Non-Communicable Disease Surveys of the main island and the island of Rodrigues were included. Participants were African (n = 1,219 from main island, n = 1,505 from Rodrigues), South Asian (n = 3,820), and Chinese (n = 157). Survey data included HbA1c, plasma glucose during oral glucose tolerance testing (OGTT), anthropometry, demographics, and medical and lifestyle history.RESULTSMean HbA1c, after adjustment for fasting and 2-h plasma glucose and other factors known to influence HbA1c, was higher in Africans from Rodrigues (6.1%) than in South Asians (5.7%, P < 0.001), Chinese (5.7%, P < 0.001), or Africans from the main island of Mauritius (5.7%, P < 0.001). The age-standardized prevalence of diabetes among Africans from Rodrigues differed substantially depending on the diagnostic criteria used [OGTT 7.9% (95% CI 5.8–10.0); HbA1c 17.3% (15.3–19.2)]. Changing diagnostic criteria resulted in no significant change in the prevalence of diabetes within the other ethnic groups.CONCLUSIONSPeople of African ethnicity from Rodrigues have higher HbA1c than those of South Asian or African ethnicity from the main island of Mauritius for reasons not explained by plasma glucose during an OGTT or traditional factors known to affect glycemia. Further research should be directed at determining the mechanism behind this disparity and its relevance to clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

“…However, some interference has been noted with HbC and -E traits (8). The prevalence of these traits in Mauritius is <1% (9). HbF has minimal interference with this method, even when levels are raised, provided that the HbF peak is correctly identified on the chromatogram (10).…”

Section: Methodsmentioning

confidence: 99%

Glucose-Independent Ethnic Differences in HbA1c in People Without Known Diabetes

et al. 2013

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“…In a total population of about 1.2 million, 68% are of Asian Indian origin, 30% of African, and 2% of Chinese and European ancestry. ␤-thalassemia is one of the most prevalent single gene defects and is found at a frequency of 4.8% among Indo-Mauritians and 2.2% among Creoles [3]. So far there is no clinical service specifically devoted to thalassemia, and the follow-up of patients is done by pediatricians.…”

Section: Introductionmentioning

confidence: 99%

Spectrum of ? thalassemia mutations and their linkage to ?-globin gene haplotypes in the Indo-Mauritians

Kotea

Ramasawmy

et al. 2000

Am. J. Hematol.

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The ␤ thalassemia alleles in 53 thalassemic Indo-Mauritian patients and their families consisting of 23 homozygous ␤-thalassemia, 9 HbE/␤-thalassemia, 18 HbS/␤-thalassemia, 1 HbD/␤-thalassemia, 1 ␦␤/␤-thalassemia and 1 HbH/␤-thalassemia from the island of Mauritius were studied. Characterization by polymerase chain reaction-based reverse dot blot hybridization technique revealed that the IVS1-5 (G→C) mutation accounted for 74% of the ␤ thalassemic alleles, while six other mutations occurred at much lower frequencies: HbE codon 26 (G→A); 10.4%, codon 8/9 (+G); 3.5%, codon 30 (AGG→ACG) also called IVSI (-1).G→C; 3.5%, codon 15 (G→A); 3.5%, codon 41/42 (−CTTT); 2.4% and -28 (A→G); 2.4%. Association of these mutations to specific ␤ globin gene sequence framework and haplotype allowed to trace their ancestral link. These data are useful in future molecular screening of the population in view of implementing a thalassemia prevention and control program in Mauritius. Am.

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Abnormal hemoglobins in mauritius Island

Cited by 2 publications

References 4 publications

Glucose-Independent Ethnic Differences in HbA1c in People Without Known Diabetes

Glucose-Independent Ethnic Differences in HbA1c in People Without Known Diabetes

Spectrum of ? thalassemia mutations and their linkage to ?-globin gene haplotypes in the Indo-Mauritians

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