Abnormal IgG cardiolipin antibody titers in patients with Raynaud’s phenomenon and/or related disorders: Prevalence and clinical significance

Vayssairat, M; Abuaf, N.; Baudot, N.; Deschamps, A; Gaitz, J P

doi:10.1016/s0190-9622(98)70116-1

Cited by 29 publications

(18 citation statements)

References 17 publications

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“…Finally, anticardiolipin (aCl) antibodies have been studied in this context, yielding conflicting results. 19 , 20 RP is caused by vasospasm of the small muscular arteries and arterioles of the digits, not by thrombosis. 19 Nevertheless thrombotic events may complicate severe forms with sustained vasospasm; patients affected by recalcitrant disease may benefit from anticoagulant therapy.…”

Section: Discussionmentioning

confidence: 99%

Systemic lupus erythematosus and Raynaud's phenomenon

Heimovski

Simioni

Skare

2015

An. Bras. Dermatol.

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BACKGROUNDPatients with systemic lupus erythematosus seem to belong to different serological and clinical subgroups of the disease. Genetic background can cause the appearance of these subgroups.OBJECTIVETo determine whether Brazilian patients who have systemic lupus erythematosus and Raynaud's phenomenon differ from those who do not.METHODSRetrospective analysis of 373 medical records of systemic lupus erythematosus patients studied for demographic, clinical and serological data. A comparative analysis was performed of individuals with and without RP.RESULTSThere was a positive association between Raynaud's phenomenon and age at diagnosis (p=0.02), presence of anti-Sm (p=0.01) antibodies and anti-RNP (p<0.0001). Furthermore, a negative association was found between Raynaud's phenomenon and hemolysis (p=0.01), serositis (p=0.01), glomerulonephritis (p=0.0004) and IgM aCL (p=0.004) antibodies.CONCLUSIONRaynaud's phenomenon patients appear to belong to a systemic lupus erythematosus subset with a spectrum of clinical manifestations located in a more benign pole of the disease.

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Section: Discussionmentioning

confidence: 99%

Systemic lupus erythematosus and Raynaud's phenomenon

Heimovski

Simioni

Skare

2015

An. Bras. Dermatol.

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“…9 However, because the prevalence of either aPL or RP is significantly higher in patients with CTD than in the normal population this finding is not surprising. On the other hand, in a case-control study limited to patients with clinical disorders such as thromboses, repeated abortions, thrombocytopenia without SLE, a significant positive association was reported between RP and aCL.…”

Section: Discussionmentioning

confidence: 96%

“…[4][5][6][7][8] Only a few studies have been performed to examine the association between RP and aCL, and conflicting results have been reported. [9][10][11][12][13] On the other hand, no data are available on the association between RP and different aPL, other than aCL.…”

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confidence: 99%

Raynaud's phenomenon and antiphospholipid antibodies in systemic lupus erythematosus: is there an association?

Caccavo

Porto²,

Garzia

et al. 2003

Annals of the Rheumatic Diseases

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“…The later group is still being followed up as JRA could shift to other CTD (25,26). An association of APL antibodies and RP is reported in adults (27) and children (5). The potential pathogenic mechanism for APL antibodies in RP is binding and activating endothelium (28).…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Value of Nailfold Capillary Changes for the Development of Connective Tissue Disease in Children and Adolescents with Primary Raynaud Phenomenon: A Follow‐up Study of 250 Patients

Pavlov-Dolijanovic

Damjanov

Ostojić

et al. 2006

Pediatric Dermatology

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To assess the prognostic value of capillaroscopy findings for the development of connective tissue disease in children and adolescents with Raynaud phenomenon, we followed up a group of 250 (mean age 15 years) for 1 to 6 years after the first capillaroscopy was performed. Every 6 months they were screened for signs and symptoms of connective tissue disease. Analysis was performed on capillary changes registered 6 months before the development of connective tissue disease. Capillary changes were classified into three types: normal, nonspecific, and sclerodermatous. At the end of the follow-up period, 191 (76%) subjects had primary Raynaud phenomenon, 27 (10.8%) were diagnosed as having undifferentiated connective tissue disease, and 32 (12.8%) fulfilled the criteria for a diagnosis of a specific connective tissue disease. Systemic lupus erythematosus was found in nine (3.6%) patients, rheumatoid arthritis in 10 (4%) patients (six of them with juvenile onset rheumatoid arthritis), and scleroderma spectrum disorders in 13 (5.2%). The mean time for the evolution of Raynaud phenomenon into undifferentiated connective tissue disease or a form of the disease was 2 years. Most of the subjects with primary Raynaud phenomenon (173/191, 91%), undifferentiated connective tissue disease (22/27, 81%), juvenile onset rheumatoid arthritis/rheumatoid arthritis (7/10, 70%), and systemic lupus erythematosus (6/9, 67%) had normal capillary findings. Nonspecific capillary changes occurred in 3 of 10 (30%) patients with rheumatoid arthritis, 2 of 9 (22%) with systemic lupus erythematosus, 4 of 27 (15%) with undifferentiated connective tissue disease, and 18 of 191 (9%) with primary Raynaud phenomenon. Of all the subjects, only 10 (4%) showed sclerodermatous disease type capillary changes 6 months before the expression of a particular disease: eight (62%) of these developed scleroderma spectrum disorders, one expressed systemic lupus erythematosus, and one had undifferentiated connective tissue disease. We concluded that there were no specific capillary changes predictive for future development of systemic lupus erythematosus, juvenile onset rheumatoid arthritis/rheumatoid arthritis, and undifferentiated connective tissue disease in children and adolescents with Raynaud phenomenon. Most of our study subjects with Raynaud phenomenon who developed these diseases had normal capillary findings or nonspecific changes. Children and adolescents who developed scleroderma spectrum disorders showed a sclerodermatous type of capillary changes 6 months before the expression of the disease, indicating that this type of capillary changes in children and adolescents with Raynaud phenomenon highly correlated with further development of scleroderma spectrum disorders.

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Abnormal IgG cardiolipin antibody titers in patients with Raynaud’s phenomenon and/or related disorders: Prevalence and clinical significance

Cited by 29 publications

References 17 publications

Systemic lupus erythematosus and Raynaud's phenomenon

Systemic lupus erythematosus and Raynaud's phenomenon

Raynaud's phenomenon and antiphospholipid antibodies in systemic lupus erythematosus: is there an association?

The Prognostic Value of Nailfold Capillary Changes for the Development of Connective Tissue Disease in Children and Adolescents with Primary Raynaud Phenomenon: A Follow‐up Study of 250 Patients

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