Abnormal keratin expression in circumscribed palmar hypokeratosis

Ishiko, Akira; Dekio, Itaru; Fujimoto, Atsushi; Kameyama, Kaori; Sakamoto, Mitsuo; Benno, Yoshimi; Amagai, Masayuki; Nishikawa, Takeji

doi:10.1016/j.jaad.2007.02.035

Cited by 51 publications

(62 citation statements)

References 14 publications

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“…CPH is a dermatosis of unknown origin, first reported in 2002 [1], of which 47 cases (including the present one) have so far been reported [2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26]. In our dermatopathology practice we have diagnosed CPH in 3 additional patients during the 7 last years [unpubl.…”

Section: Discussionmentioning

confidence: 99%

“…CPH is seen predominantly in adult women (female:male ratio 4:1) of a mean age of 65 ± 11 years (range 35–84) and has been described in patients from Spain [1], Germany [6,12,20], Austria [2], France [ [25,]this case], Malta [17], Italy [24], the USA [5,11,22,26], Chile [9], Peru [10], Korea [7,13], Japan [14,15,19,23] and New Zealand [16]. The clinical appearance of the lesions is stereotypical: they consist in a sharply circumscribed plaque with a erythematous, somewhat depressed surface, rimmed by a slightly hyperkeratotic border.…”

Section: Discussionmentioning

confidence: 99%

“…Urbina et al [9] considered CPH to be a keratinizing disorder localized to the granular and horny layers. This view is upheld by the finding of altered keratin expression in the lesional epidermis [19,23]. More recently, a reduction of keratin 9 and connexin 26 expression at the lesional epidermis was noted, and the view has been expressed that CPH could encompass two different entities, linked to abnormalities of these two epidermal differentiation antigens, respectively [23].…”

Section: Discussionmentioning

confidence: 99%

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Premalignant Circumscribed Palmar Hypokeratosis: A New Form of Circumscribed Palmar Hypokeratosis? Case Report and Literature Review

Kanitakis¹,

Lora²,

Balme³

et al. 2009

Dermatology

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Circumscribed palmoplantar hypokeratosis (CPH) is a recently described dermatosis of unknown origin, of which 46 cases have been published so far. CPH affects predominantly adult women. It presents clinically with a sharply circumscribed annular erythematous depressed plaque rimmed by a slightly hyperkeratotic border, localized usually over the thenar or hypothenar eminences of the palm, less commonly on the soles. Histopathologically, it is characterized by an abrupt decrease in the horny layer thickness, forming a sharp stair between normal and involved skin. We report herein a new patient with CPH who presented an associated aspect of actinic keratosis, a hitherto unreported finding. This case suggests that CPH can undergo malignant transformation, probably as a result of actinic damage. On this occasion, a complete literature review of CPH is presented.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Premalignant Circumscribed Palmar Hypokeratosis: A New Form of Circumscribed Palmar Hypokeratosis? Case Report and Literature Review

Kanitakis¹,

Lora²,

Balme³

et al. 2009

Dermatology

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“…20 Vacuolar changes have also been observed in the corneocytes at the deep margin of the areas of hypokeratosis. 20 One study has provided evidence of decreased keratinocyte maturation, with thinning of the granular layer in the area of the union between lesional and normal skin.…”

Section: Electron Microscopymentioning

confidence: 99%

“…This is an acquired disorder that is more common in women, with a female to male ratio of 3.3 to 1, and it has been reported in patients aged between 42 and 84 years (mean age, 64.6 years) at the time of first consultation (one outlying case with lesions present from birth 44 was excluded from this calculation). In a large majority of cases (60 patients) the lesions were single; there were only 8 cases with 2 lesions, 3,11,13,20,21,27,29 one with 3 lesions, 31 and an exceptional case with 13 lesions in a linear distribution 21 (also excluded from the calculations as it was an outlier). Most lesions were located on the right palm, mainly affecting the thenar region (44 of 79 lesions).…”

Section: Clinical Presentationmentioning

confidence: 99%

Circumscribed Palmar or Plantar Hypokeratosis 10 Years After the First Description: What Is Known and the Issues Under Discussion

Urbina¹,

Pérez²,

Requena³

et al. 2014

Actas Dermo-Sifiliográficas (English Edition)

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This review of the literature on palmoplantar hypokeratosis, a process that was first indentified only 10 years ago, discusses the current state of our understanding, the therapeutic options available, and the debate about etiology. Forty-four publications reporting 69 cases were found. Palmar or plantar hypokeratosis occurs mainly in women (76.8%) and age at the time of a first visit to a physician ranges from 42 to 84 years. Most cases present between the ages of 51 and 70 years. The majority of patients have had solitary lesions usually located on the right palm, particularly in the regions of the thenar (in 44/79 lesions [55.7%]) or hypothenar eminences (in 11/79 lesions [13.9%]). In only 8 cases was there a history of prior trauma at the site. Studies using polymerase chain reaction techniques to identify human papillomavirus involvement were negative in most cases. These hypokeratotic lesions are localized epidermal depressions formed by an abrupt thinning of the stratum corneum, providing a singular histopathologic feature. This condition can currently be considered a localized keratinization disorder affecting zones where there is a thick stratum corneum. The precipitating cause is unknown and a definitive treatment remains to be found. The mechanism would be the localized failure of a clone of keratinocytes during differentiation toward normal palmoplantar hyperkeratinization. Palmas y plantas; Hipoqueratosis circunscrita palmar o plantar. Conocimientos y controversias tras 10 años de su descripciónResumen Se revisa el estado actual de un nuevo proceso y los avances que han ido apareciendo en la literatura respecto a su estudio, posibilidades terapéuticas y controvertida etiología, tras ଝ Please cite this article as: Urbina F, Pérez A, Requena L, Rütten A. Hipoqueratosis circunscrita palmar o plantar. Conocimientos y controversias tras 10 años de su descripción. Actas Dermosifiliogr. 2014;105:574---582.Palmar or Plantar Hypokeratosis 575 Palmoplantar; Queratinización; Queratinocito justo una década de su descripción inicial. Hemos encontrado 44 publicaciones al respecto, con 69 casos. Predomina en mujeres (76,8%), con edades entre los 42 y 84 años para toda la casuística en el momento de la consulta, siendo el rango más frecuente de aparición de las lesiones entre los 51 y 70 años. La gran mayoría de las veces fueron lesiones únicas y se localizaron predominantemente en la palma derecha, preferentemente en la región tenar, con 44/79 lesiones (55,7%) y luego en la hipotenar, con 11/79 lesiones (13,9%). Solo en 8 casos se obtuvo el antecedente de un traumatismo previo. Los estudios mediante PCR en búsqueda de papiloma virus humano han sido negativos la gran mayoría de las veces. Las lesiones consistieron en una depresión focalizada de la epidermis producida por una brusca disminución de espesor de la capa córnea, delimitando un singular concepto histolopatológico. En la actualidad puede ser considerada como un trastorno focalizado de la queratinización, que afecta zonas con un estrato córneo grueso, cuya c...

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