Abnormal Levels of Serum Ferroptosis-Related Biomarkers in Diabetic Retinopathy

Mu, Lin; Wang, Dahu; Dong, Zhiguo; Wu, Jiajun; Wu, Xiaoyu; Su, Jing; Zhang, Yinjian

doi:10.1155/2022/3353740

Cited by 16 publications

(8 citation statements)

References 30 publications

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“…[ 8 ] The decreased concentrations of serum GPx4 were also observed in patients with diabetic retinopathy compared with healthy subjects. [ 9 ] The acute coronary syndrome patients had lower plasma GPx4 levels than controls. [ 24 ] The reduction of GPX4 plays a central regulatory role in ferroptosis.…”

Section: Discussionmentioning

confidence: 99%

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Serum glutathione peroxidase 4 as a novel biomarker for nontraumatic osteonecrosis of the femoral head: A retrospective case-control study

Zhao,

Dong,

Wang

et al. 2023

Medicine

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There are no serum biomarkers available in nontraumatic osteonecrosis of the femoral head in clinical practice. This study aimed to evaluate the clinical value of serum glutathione peroxidase 4 in nontraumatic osteonecrosis of the femoral head. This retrospective study analyzed serum glutathione peroxidase 4 levels and clinical data of 80 patients with nontraumatic osteonecrosis of the femoral head and 80 healthy controls between August 2021 and May 2022. Serum glutathione peroxidase 4 levels were analyzed using an enzyme-linked immunosorbent assay. The Association Research Circulation Osseous classification system determined disease progression. Clinical severity was assessed by Harris hip score and visual analogue scale. Correlations between serum glutathione peroxidase 4 and disease progression as well as clinical severity were evaluated statistically. The diagnostic accuracy of serum glutathione peroxidase 4 in nontraumatic osteonecrosis of the femoral head was determined using receiver operating characteristic analysis. The baseline characteristics of participants between 2 groups were comparable. Patients with nontraumatic osteonecrosis of the femoral head displayed a decreased glutathione peroxidase 4 level compared with healthy controls (11.87 ± 2.76 μU/mL vs 16.54 ± 4.89 μU/mL, P < .01). The levels of glutathione peroxidase 4 were inversely correlated with Association Research Circulation Osseous stage (P < .01) and visual analogue scale scores (P < .01), and positively correlated with Harris score (P < .01). Receiver operating characteristic analyses showed that area under curves of glutathione peroxidase 4 was 0.808 (95% CI 0.721–0.858) and 0.847 (95% CI 0.743–0.951) with regard to diagnosis and collapse prediction in nontraumatic osteonecrosis of the femoral head, respectively. Serum glutathione peroxidase 4 could serve as a novel biomarker for diagnosing nontraumatic osteonecrosis of the femoral head and predicting collapse of the femoral head.

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Section: Discussionmentioning

confidence: 99%

“…For example, serum GPx4 showed good performance in diagnosing gestational diabetes mellitus [ 8 ] and diabetic retinopathy. [ 9 ] GPx4 was also associated with disease progression in diabetic kidney disease. [ 10 ] No study has investigated the relationship between blood GPx4 and patients with NONFH.…”

Section: Introductionmentioning

confidence: 99%

Serum glutathione peroxidase 4 as a novel biomarker for nontraumatic osteonecrosis of the femoral head: A retrospective case-control study

Zhao,

Dong,

Wang

et al. 2023

Medicine

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“…Liu et al demonstrated that in human retinal endothelial cells cultured under high-glucose conditions, long non-coding RNA zinc finger antisense 1 (ZFAS1) is upregulated and activates ferroptosis by modulating the expression of ACSL4 [ 92 ]. A recent clinical study indicated that compared to those of the normal group, the serum levels of GPX4 and GSH were significantly lower and lipid peroxide, iron, and ROS were significantly higher in patients with DR [ 93 ]. Thus, ferroptosis-related biomarkers may be involved in the pathological processes of DR [ 93 ].…”

Section: Various Types Of Retinal Cell Death In Drmentioning

confidence: 99%

Neurovascular Cell Death and Therapeutic Strategies for Diabetic Retinopathy

Oshitari

2023

IJMS

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Diabetic retinopathy (DR) is a major complication of diabetes and a leading cause of blindness worldwide. DR was recently defined as a neurovascular disease associated with tissue-specific neurovascular impairment of the retina in patients with diabetes. Neurovascular cell death is the main cause of neurovascular impairment in DR. Thus, neurovascular cell protection is a potential therapy for preventing the progression of DR. Growing evidence indicates that a variety of cell death pathways, such as apoptosis, necroptosis, ferroptosis, and pyroptosis, are associated with neurovascular cell death in DR. These forms of regulated cell death may serve as therapeutic targets for ameliorating the pathogenesis of DR. This review focuses on these cell death mechanisms and describes potential therapies for the treatment of DR that protect against neurovascular cell death.

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“…Accumulating evidence has demonstrated, the process by which ferroptosis occurs is closely associated with immune regulation, in ammatory regulation and mitochondrial metabolism of cells [18,19]. More and more experimental veri cation shows that ferroptosis have a close relationship with the treatment and diagnosis of various diseases such as cancers (PAAD [20], CA [21], COAD [22]), diabetes complications (DN [23], DR [24]), and cardiovascular diseases [25].…”

Section: Introductionmentioning

confidence: 99%

Screening and identification of genes related to ferroptosis in keratoconus

Deng

Han

et al. 2023

Preprint

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Background: Corneal keratoconus (KC) is a dilated corneal disease characterized by a central thinning of the cornea, which protrudes into a conical shape and seriously affects vision. However, due to the complex etiology of keratoconus, it is not yet clear and there is no effective treatment method. Ferroptosis is a novel programmed cell death mechanism related to lipid peroxidation, stress, and amino acid metabolism, playing a crucial role in various diseases. This study aims to explore the relationship between keratoconus and ferroptosis, and provide new insights for the treatment of keratoconus diseases Methods: The corresponding mRNA microarray expression matrix data of KC patients were obtained from GEO database (GEO204791). Weighted co-expression network analysis (WGCNA) and support vector machine recursive feature elimination (SVM-RFE) were selected to screen hub genes. And the hub genes were overlapped with ferroptosis genes (FRGs) from FerrDb. GO and GSEA were performed to analyze differential pathways, ssGSEA was used to determine immune status, and then, feasible drugs were predicted by gene-drug network. At the same time, we predicted the miRNA and IncRNA of hub genes to identify the underlying mechanism of disease and predicted the treatment of disease. Results: The epithelial transcriptome from keratoconus tissue mRNA microarray data (GSE204791) was extracted for the main analysis, including eight epithelial cells (EKC) and eight epithelial control cells (EN). The differential genes that were overlapped by WGCAN, SVM-RFE and FRGs were mainly related to oxidative stress, immune regulation, cellular inflammation and metal ion transport. Aldo-keto reductase family 1 member C3 (AKR1C3) was selected out, through further analysis, and negatively correlated with mature CD56 natural killer (NK) cells and macrophages. And then, gene-drug interaction network analysis and miRNA prediction were performed through the website. At the end, A total of four Immune-related drugs (INDOMETHACIN, DAUNORUBICIN, DOXORUBICIN，DOCETAXEL) and a miRNA (has-miR-184) were screened to predict potential drugs and targets for disease treatment. Conclusion: For the first time , we associated KC with ferroptosis, searched for differential genes to predict the drug targets of gene immunotherapy. Our findings provided a viewpoint and insight for the analysis and treatment of KC.

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Abnormal Levels of Serum Ferroptosis-Related Biomarkers in Diabetic Retinopathy

Cited by 16 publications

References 30 publications

Serum glutathione peroxidase 4 as a novel biomarker for nontraumatic osteonecrosis of the femoral head: A retrospective case-control study

Serum glutathione peroxidase 4 as a novel biomarker for nontraumatic osteonecrosis of the femoral head: A retrospective case-control study

Neurovascular Cell Death and Therapeutic Strategies for Diabetic Retinopathy

Screening and identification of genes related to ferroptosis in keratoconus

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