2023
DOI: 10.3390/ijms241612919
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Neurovascular Cell Death and Therapeutic Strategies for Diabetic Retinopathy

Toshiyuki Oshitari

Abstract: Diabetic retinopathy (DR) is a major complication of diabetes and a leading cause of blindness worldwide. DR was recently defined as a neurovascular disease associated with tissue-specific neurovascular impairment of the retina in patients with diabetes. Neurovascular cell death is the main cause of neurovascular impairment in DR. Thus, neurovascular cell protection is a potential therapy for preventing the progression of DR. Growing evidence indicates that a variety of cell death pathways, such as apoptosis, … Show more

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Cited by 10 publications
(2 citation statements)
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“…Endothelial cell death was observed in retina of diabetic patients and diabetic rat model [ 86 ]. Growing evidence shows that multi-modes of cell death, such as apoptosis [ 85 , 87 ], necroptosis [ 88 ], ferroptosis [ 89 , 90 ], pyroptosis [ 91 , 92 ], and parthanatos [ 93 ], are associated with retinal endothelial cell death in DR [ 4 , 94 ]. Oxidative stress, leukostasis, and inflammation are the main underlying mechanisms for retinal endothelial cell death.…”
Section: The Cell–cell Contacts Are Altered In Drmentioning
confidence: 99%
“…Endothelial cell death was observed in retina of diabetic patients and diabetic rat model [ 86 ]. Growing evidence shows that multi-modes of cell death, such as apoptosis [ 85 , 87 ], necroptosis [ 88 ], ferroptosis [ 89 , 90 ], pyroptosis [ 91 , 92 ], and parthanatos [ 93 ], are associated with retinal endothelial cell death in DR [ 4 , 94 ]. Oxidative stress, leukostasis, and inflammation are the main underlying mechanisms for retinal endothelial cell death.…”
Section: The Cell–cell Contacts Are Altered In Drmentioning
confidence: 99%
“…Diabetic retinopathy (DR) is one of the most serious complications of diabetes and a leading cause of blindness in adults worldwide. Currently, there is a lack of effective measures to reverse DR, which greatly reduces the quality of life for diabetic patients and places a heavy burden on their families and society [3,4]. Therefore, how to prevent and treat DR at an early stage is still a focus of current research.…”
Section: Introductionmentioning
confidence: 99%