Abnormal metabolism of secondary bile acids in patients with cirrhosis

A simple and accurate HPLC method for fecal bile acid profile in healthy and cirrhotic subjects: validation by GC-MS and LC-MS

“…3 ) The absorbance of bile acid-phenacyl esters at 254 nm is excellent, providing high sensitivity; and in addition, there published results ( 7 ) as well as an older study by Vlahcevic et al ( 28 ).…”

Role of primary and secondary bile acids as feedback inhibitors of bile acid synthesis in the rat in vivo.

“…This may well have a bearing on cholesterol gallstone disease, since in some studies there was a relationship between deoxycholic acid and cholesterol in bile (50). On the other hand, at least a subgroup of gallstone patients has low rates of bile acid synthesis (51) and low pool sizes (52). Moreover, clinical situations with an increased bile acid loss through dysfunction or resection of the terminal ileum are accompanied by a compensatory increase in bile acid synthesis (53) and are often characterized by a low deoxycholate pool size (54).…”

The role of microbiota in hepatic encephalopathy

“…A potential mechanism could be the decrease in bile acid production as cirrhosis advances which can modulate the presence of autochthonous taxa in the gut. [30][31][32] The conversion from the primary to secondary BAs is seen as a key feature of microbial functionality, which is impaired as cirrhosis progresses. 31,32 Autochthonous taxa such as Lachnospiraceae, Ruminococcaceae, and Clostridiales Cluster XIV (consist of several genera and species such as Fecalibacterium and/or Roseburia) have the ability to generate nutritive short-chain fatty acids, strengthen the integrity of the gut barrier, and are often seen as the "healthy" microbiota.…”