Abnormal Neural Oscillatory Activity to Speech Sounds in Schizophrenia: A Magnetoencephalography Study

Hirano, Shogo; Hirano, Yoji; Maekawa, Toshihiko; Obayashi, Choji; Oribe, Naoya; Kuroki, Tetsuo; Kanba, Shigenobu; Onitsuka, Toshiaki

doi:10.1523/jneurosci.5031-07.2008

Cited by 69 publications

(60 citation statements)

References 24 publications

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“…Like most (Krishnan, Hetrick, 2009, Light, Hsu, 2006, Spencer, Niznikiewicz, 2009, Spencer, Salisbury, 2008, Teale, Collins, 2008), but not all (Hamm, Gilmore, 2011), prior reports, we found a reduction in the PLF, or phase consistency across trials, of the 40 Hz ASSR in SZ patients. We also found reduced auditory GBR PLF, consistent with our prior report (Roach and Mathalon, 2008) from a patient sample that partially overlapped with the current sample, and replicating some (Hall, Taylor, 2009, Hirano, Hirano, 2008, Leicht, Kirsch, 2010), but not all (Krishnan, Hetrick, 2009, Spencer et al, 2007, Teale, Collins, 2008), prior studies. Further, reduced total power in SZ relative to HC in both the 40 Hz ASSR and GBR measures replicates the findings of Krishnan et al (Krishnan, Hetrick, 2009).…”

Section: Discussionsupporting

confidence: 90%

“…However, we are unaware of any study that directly correlated the two measures. In addition, despite multiple reports of abnormal GBR (Hall et al, 2011, Hall et al, 2009, Hirano et al, 2008, Leicht et al, 2010, Lenz et al, 2010, Roach and Mathalon, 2008, Teale et al, 2008) and 40 Hz ASSR (Brenner et al, 2003, Hamm et al, 2011, Krishnan et al, 2009, Kwon et al, 1999, Light et al, 2006, Spencer et al, 2009, Spencer et al, 2008, Teale, Collins, 2008, Vierling-Claassen et al, 2008, Wilson et al, 2008) in schizophrenia, no study has examined the relationship between these measures in the same patient sample to determine if they reflect distinct pathophysiological processes. Accordingly, the present study examines the relationship between GBR and ASSR in healthy controls and patients with schizophrenia, and further compares the relative sensitivity of these measures to the pathophysiology underlying deficient gamma oscillations in schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

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Converging evidence for gamma synchrony deficits in schizophrenia

Roach

Ford

Hoffman

et al. 2013

Supplements to Clinical Neurophysiology

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Background In electroencephalogram (EEG) studies of auditory steady-state responses (ASSR), patients with schizophrenia show a deficit in power and/or phase-locking, particularly at the 40Hz frequency where these responses resonate. In addition, studies of the transient gamma band response (GBR) elicited by single tones have revealed deficits in gamma power and phase-locking in schizophrenia. We examined the degree to which the 40 Hz ASSR and the transient GBR to single tones are correlated and whether they assess overlapping or distinct gamma band abnormalities in schizophrenia. Methods EEG was recorded during 40 Hz ASSR and auditory oddball paradigms from 28 patients with schizophrenia or schizoaffective disorder (SZ) and 25 age- and gender-matched healthy controls (HC). The ASSR was elicited by 500 ms click trains, and the transient GBR was elicited by the standard tones from the oddball paradigm. Gamma phase and magnitude values, calculated using Morlet Wavelet transformations, were used to derive total power and phase-locking measures. Results Relative to HC, SZ patients had significant deficits in total gamma power and phase-locking for both ASSR- and GBR-based measures. Within both groups, the 40 Hz ASSR and GBR phase-locking measures were significantly correlated, with a similar trend evident for the total power measures. Moreover, co-varying for GBR substantially reduced 40 Hz ASSR power and phase-locking differences between the groups. Conclusions 40 Hz ASSR and transient GBR measures provide very similar information about auditory gamma abnormalities in schizophrenia, despite the overall enhancement of 40 Hz ASSR total power and phase-locking values relative to the corresponding GBR values.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Converging evidence for gamma synchrony deficits in schizophrenia

Roach

Ford

Hoffman

et al. 2013

Supplements to Clinical Neurophysiology

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“…Interestingly, a similar pattern has been reported in previous task-related studies of gamma-band oscillations: Although both the stimulus-locking of local gamma-band phase 19,31,32 and the long-range synchrony of gamma oscillations 16 are reduced in patients with schizophrenia, their correlation with positive symptoms is a positive one. In contrast, a study that reported an increased delayed left-hemisphere gamma-band response to speech in patients with schizophrenia 13 found a negative correlation with hallucination severity. All the above findings indicate that increased psychopathology is associated with more "normal" measures of local phase-coupling and/or interregional synchronization in the gamma frequency range.…”

Section: Discussionmentioning

confidence: 68%

Increased Resting-State Gamma-Band Connectivity in First-Episode Schizophrenia

Andreou

Nolte

Leicht

et al. 2014

SCHBUL

116

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Background: Schizophrenia has long been suggested to represent a disorder with prominent neural dysconnectivity. Gamma-band oscillations are highly relevant in this context, due both to their proposed involvement in neuronal synchronization and to their association with neurotransmitter systems relevant for schizophrenia. Several task-related studies have confirmed reduced power and synchronization of gamma-band oscillations in schizophrenia, but it has been suggested that these findings might not apply to the resting state. The present study aimed to investigate resting-state gamma-band connectivity in patients with schizophrenia. Methods: Sixtyfour channel resting-state electroencephalography (eyes closed) was recorded in 22 patients with first-episode schizophrenia and 22 healthy controls matched for age and gender. Orthogonalized power envelope correlation was used as a measure of connectivity across 80 cortical regions at 40 Hz. Mean connectivity at each region was compared across groups using the nonparametric randomization approach. Additionally, the network-based statistic was applied to identify affected networks in patients. Results: Patients displayed increased mean functional gamma-band connectivity compared to controls in the left rolandic operculum. Network-based analyses indicated increased connectivity in patients within a strongly lateralized network consisting mainly of left inferior frontal/ orbitofrontal, lateral and medial temporal, and inferior parietal areas. Within this network, gamma-band connectivity was higher in patients with low positive and disorganization symptom levels. Conclusions: The present study provides a link between resting-state gamma-band connectivity and the core symptoms of schizophrenia. The observed findings are different than those reported by task-related studies, suggesting that resting-state studies might reveal new aspects in the pathophysiology of schizophrenia.

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“…36 Reductions in gamma-band amplitude have been demonstrated for a wide range of cognitive and perceptual paradigms, including working memory, 37 executive control, 38 and perceptual processing. 39,40 There is preliminary evidence that the decrease in gamma-band spectral power is independent of medication status. 38 …”

Section: High-frequency Oscillations In Schizophreniamentioning

confidence: 99%

High-Frequency Oscillations in Schizophrenia

Uhlhaas

2011

Clin EEG Neurosci

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Neural oscillations and their synchronization may represent a versatile signal to realize flexible communication within and between cortical areas. There is extensive evidence that cognitive functions depending on coordination of distributed neural responses are associated with synchronized oscillatory activity, suggesting a functional mechanism of neural oscillations in cortical networks. In addition to their role in normal brain functioning, there is increasing evidence that altered oscillatory activity may be associated with certain neuropsychiatric disorders, such as schizophrenia, that involve dysfunctional cognition and behavior. In the present paper, the focus is on the role of high-frequency oscillations for cortical computations through establishing correlations between the modulation of oscillations in the beta/gamma frequency range and specific cognitive processes during normal brain functioning and in schizophrenia. Specifically, it is suggested that in addition to oscillations in the low (30-60 Hz) gamma-band range, gamma-band oscillations > 60 Hz may have a crucial role for the understanding of cognitive dysfunctions in schizophrenia. Perspectives for future research will be discussed in relationship to methodological issues, the utility of neural oscillations as a biomarker and the neurodevelopmental hypothesis of schizophrenia.

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Abnormal Neural Oscillatory Activity to Speech Sounds in Schizophrenia: A Magnetoencephalography Study

Cited by 69 publications

References 24 publications

Converging evidence for gamma synchrony deficits in schizophrenia

Converging evidence for gamma synchrony deficits in schizophrenia

Increased Resting-State Gamma-Band Connectivity in First-Episode Schizophrenia

High-Frequency Oscillations in Schizophrenia

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