Abnormal perceptual sensitivity in body-focused repetitive behaviors

Houghton, David C.; Alexander, Jennifer R.; Bauer, Carolyn M.; Woods, Douglas W.

doi:10.1016/j.comppsych.2017.12.005

Cited by 26 publications

(19 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies already demonstrated that grooming behavior could be related to sensory components (Houghton et al, 2018). Corroborating a previous work from our group (Fontes-Dutra et al, 2018), we observed that VPA animals presented hypersensitivity to a non-harmful stimulus in WNT, suggesting a disturbance in sensory gating which could lead to increase in self-grooming behavior.…”

Section: Discussionsupporting

confidence: 85%

Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism

et al. 2020

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) is characterized by deficits in communication and social interaction, restricted interests, and stereotyped behavior. Environmental factors, such as prenatal exposure to valproic acid (VPA), may contribute to the increased risk of ASD. Since disturbed functioning of the purinergic system has been associated with the onset of ASD and used as a potential therapeutic target for ASD in both clinical and preclinical studies, we analyzed the effects of suramin, a nonselective purinergic antagonist, on behavioral, molecular and immunological in an animal model of autism induced by prenatal exposure to VPA. Treatment with suramin (20 mg/Kg, intraperitoneal) restored sociability in the three-chamber apparatus and decreased anxiety measured by elevated plus maze apparatus, but had no impact on decreased reciprocal social interactions or higher nociceptive threshold in VPA rats. Suramin treatment had no impact on VPA-induced upregulation of P2X4 and P2Y2 in hippocampus, and P2X4 in medial prefrontal cortex, but normalized an increased level of interleukin 6 (IL-6). Our results suggest an important role of purinergic modulation in behavioral, molecular, and immunological aberrations described in VPA model, and suggest that purinergic system might be a potential target for pharmacotherapy in preclinical studies of ASD.

show abstract

Section: Discussionsupporting

confidence: 85%

Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The present findings may also have implications beyond MCS, extending a range of somatic issues (i.e. perceptual sensitivities) that are found across multiple forms of psychopathology including autism spectrum disorders (3), Tourette's disorder (2), obsessivecompulsive disorder (105), trichotillomania (106,107), attention-deficit/hyperactivity disorder (108)(109)(110), posttraumatic stress disorder (111)(112)(113), panic disorder (115), generalized anxiety disorder (115), and social phobia (115). Mean (SEM) percent change from baseline in the detection (threshold score) of phenyl ethyl alcohol (PEA), a neutral, rose-like, odor.…”

Section: Discussionmentioning

confidence: 83%

Exploratory Investigation of a Brief Cognitive Behavioral Intervention and Transcranial Direct Current Stimulation on Odor Sensitivity

et al. 2019

Self Cite

View full text Add to dashboard Cite

OBJECTIVE: Enhanced odor sensitivity is a phenomenon that potentially underlies conditions such as multiple chemical sensitivity (MCS). Currently, there are no treatments that have been shown to effectively decrease odor sensitivity. Given similarities of odor hypersensitivity/MCS to pain sensitization disorders such as fibromyalgia, there may be a potential for interventions that improve pain tolerance to modulate odor sensitivity. METHODS: This exploratory study randomized 72 healthy community adult volunteers to receive one of six treatments in between two assessments of thermal pain tolerance and odor threshold. Participants were randomized to receive either cathodal, anodal, or sham transcranial direct current stimulation (tDCS) aimed at dorsolateral prefrontal cortex. Additionally, participants were provided a brief cognitive behavioral intervention (CBI) for pain consisting of task framing, cognitive restructuring, and distraction technique training, or a control intervention consisting of information about pain. RESULTS: Persons who received brief CBI showed significantly increased odor thresholds (reduced sensitivity) over the course of intervention (F[1, 62] = 7.29, p = .009, η p 2 = .11), whereas the control intervention was not associated with altered odor thresholds. Moreover, in those that received brief CBI, more severe anxiety associated with larger reductions in odor sensitivity (ρ =. 364, p = .035). There was no effect of tDCS (F[2, 62] = .11, p = .90), nor interaction between tDCS and CBI (F[2, 62] = .32, p = .73). CONCLUSIONS: Given the connection between anxiety and MCS, results suggest that CBT techniques for somatic processes may show promise in treating conditions characterized by increased sensitivity to odors (e.g. MCS).

show abstract

“…Negative outcomes such as health and esthetical hitches and socio-emotional snags are allied with BFRBD (Ghanizadeh, 2011;Odlaug et al, 2010). In BFRBD an individual consistently squirms with his body that results in physical harm (Houghton et al, 2018;Morand-Beaulieu et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

The Mediating Role of Parental Behavior between Anxiety and Body focused Repetitive Behavior Disorder among Adolescents

Yasir

2022

plhr

View full text Add to dashboard Cite

This study was conducted to find out the mediating role of Parental behavior between Anxiety and Body focused repetitive behavior disorders among adolescents. The sample size is comprised of 130 adolescents. The sample includes both male and female participants of higher educational institutions. The scales used for the current study are; The Trichotillomania Scale for Children/adolescents and Parental Bonding Instrument. The results of the study concluded that parental behavior mediates the relationship between anxiety and body focused repetitive behavior disorders. The findings of the study would be beneficial for those designing the therapeutic programs for the patients of anxiety and Body focused repetitive behavior disorders. The results of the study are also important to find out the different aspects of the psychological health of the critical age period of adolescents. The study contributes in the development of the treatment plans for psychologists, councilors and mental health professionals to deal with the mental health problems of the adolescents.

show abstract

Abnormal perceptual sensitivity in body-focused repetitive behaviors

Abstract: These findings suggest that several sensory abnormalities may underlie BFRBs. Implications for the etiology and treatment of BFRBs are discussed.

Cited by 26 publications

References 75 publications

Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism

Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism

Exploratory Investigation of a Brief Cognitive Behavioral Intervention and Transcranial Direct Current Stimulation on Odor Sensitivity

The Mediating Role of Parental Behavior between Anxiety and Body focused Repetitive Behavior Disorder among Adolescents

Contact Info

Product

Resources

About