Abnormal respiratory drive in vibroacoustic disease

Ferreira, José Reis; Sousa, Jorge Henrique Bento de; Foreid, Peter; Antunes, Marco; Cardoso, Sofia; Alves-Pereira, Mariana; Branco, N. A. A. Castelo

doi:10.1016/s2173-5115(06)70408-0

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…Infrasound pollution can cause human organ dysfunction and cardiac injury [6]. Animal experiments showed that infrasound destroyed hearing, cardiac, respirational, gastrointestinal, and circulation systems [7]. Particularly, infrasound impaired the central nervous system (CNS) and cognitive abilities [8].…”

Section: Introductionmentioning

confidence: 99%

Tetrahydroxystilbene Glucoside Ameliorates Infrasound-Induced Central Nervous System (CNS) Injury by Improving Antioxidant and Anti-Inflammatory Capacity

Zhou

Yang

Fan

et al. 2020

Oxidative Medicine and Cellular Longevity

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Background. Infrasound is a major threat to global health by causing injuries of the central nervous system (CNS). However, there remains no effective therapeutic agent for preventing infrasound-caused CNS injury. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glycoside (THSG) exerts protective function against CNS injuries and may have beneficial effects on infrasound-induced CNS impairment. Methods. A mouse model with CNS (oxidative stress-induced inflammation and neuronal apoptosis) injuries was established when the mouse was exposed to the infrasound of 16 Hz at 130 dB for 2 h each day and the duration of treatment was 8 d. The mice were divided into the control (CG, healthy mice), the model (MG, model mice), and the THSG (EG, experimental group, model mice treated with THSG) groups. The learning and memory impairments caused by infrasound were examined using a Morris water maze test. Lipid profiles, antioxidant biomarkers, and inflammatory cytokines in hippocampus tissue were measured by using corresponding ELISA kits. Meanwhile, BCL-2/BAX/caspase-3 signaling pathway was measured in the hippocampi and prefrontal cortex of the mouse brain using real-time qPCR and Western blot. Nissl’s stain was used to measure neuronal necrosis in the hippocampi and prefrontal cortex of the mouse brain. Results. THSG significantly ameliorated the learning and memory impairments caused by infrasound. On the other hand, THSG improved lipid profiles, increased antioxidant properties by affecting the levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and malondialdehyde (MDA), and displayed anti-inflammatory action via the downregulation of IL- (interleukin-) 6, IL-8, IL-10, TNF- (tumor necrosis factor-) α, and hs-CRP (high-sensitivity C-reactive protein) in the hippocampal tissues of the mouse model (P<0.05). Additionally, Nissl’s stain showed that THSG inhibited infrasound-induced neuronal necrosis in the hippocampi and prefrontal cortex. Besides, THSG exerted antiapoptosis function by upregulating the level of Bcl-2 and downregulating the levels of BAX and caspase-3 in the hippocampi. Conclusion. THSG may be an effective anti-infrasound drug against CNS injury by improving antioxidant, anti-inflammatory, antiapoptosis, and antinecrosis capacities. Further research is still needed to confirm the exact molecular mechanism.

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Section: Introductionmentioning

confidence: 99%

Tetrahydroxystilbene Glucoside Ameliorates Infrasound-Induced Central Nervous System (CNS) Injury by Improving Antioxidant and Anti-Inflammatory Capacity

Zhou

Yang

Fan

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Many kinds of synchronism are observable in our body, also a relation between a tactile and an auditive stimulation [27]. At high levels such a synchronous multi-sensory stimulation may cause, what is called vibro-acoustic disease (VAD) [28,29].…”

Section: Discussionmentioning

confidence: 99%

Why is sharp-limited low-frequency noise extremely annoying

Krahe

2008

The Journal of the Acoustical Society of America

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Sharp-limited low-frequency noise having only weak components of higher frequencies, such as noise of an air condition or traffic noise attenuated by a thick window, has a very annoying effect on persons also at low levels. The strong fluctuation, which is specific to this kind of sound, is a frequently used explanation for this effect possibly caused by adaptation in the inner ear. Another or additional explanation could be a strong synchronism in the activities on the nerve fibers. Computer models of the auditory system show this synchronism. If some components at higher frequencies are added, the synchronism disappears and the noise is judged less uncomfortable. This raises the question, if noise protection resulting in a sound as described can not be even counterproductive. Differently sharp-limited sounds are investigated by an auditory model and the results are discussed.

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