Abnormalities in Event‐Related Potentials, N100, P200, P300 and Slow Wave in Schizophrenia

Ogura, Chikara; Nageishi, Yasuhiro; Matsubayashi, Minoru; Omura, Fumiaki; Kishimoto, Akira; Shimokochi, Minora

doi:10.1111/j.1440-1819.1991.tb00506.x

Cited by 35 publications

(27 citation statements)

References 19 publications

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“…However, patterns of AEP abnormalities differ among various psychiatric diagnoses. For example, patients with schizophrenia display decreased amplitudes of the P50 and N100 as well as P200 amplitudes that vary with task and state (Boutros et al, 1997;Jin et al, 1997;Ogura et al, 1991;Tabares-Seisdedos et al, 2001). In contrast to schizophrenia, patients with major depression display normal N100 amplitude and increased P200 amplitude (Vandoolaeghe et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Corticosterone Modulates Auditory Gating in Mouse

Maxwell

Ehrlichman

Liang

et al. 2005

Neuropsychopharmacol

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Previous studies suggest that circulating glucocorticoids may influence the encoding and processing of sensory stimuli. The current study investigated this hypothesis by measuring the generation (amplitude), gating (recovery cycle), and sensitivity (intensity function) of auditory evoked responses in C57BL/6 mice treated with chronic corticosterone (0, 1, 5, 15, or 30 mg/kg/day for 14 days). We found that low-dose corticosterone (5 but not 1 mg/kg/day) enhanced the amplitude and improved gating of evoked potentials without affecting the intensity function. In comparison, higher doses (15 and 30 mg/kg/day) decreased the amplitude and impaired gating of evoked potentials, also without altering the stimulus intensity function. At all doses, lower amplitudes of evoked potentials were significantly correlated with higher circulating corticosterone levels. These data highlight the need to consider serum glucocorticoid levels when assessing human disease states associated with aberrations of information processing such as schizophrenia and depression.

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Section: Discussionmentioning

confidence: 99%

Corticosterone Modulates Auditory Gating in Mouse

Maxwell

Ehrlichman

Liang

et al. 2005

Neuropsychopharmacol

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“…Similarly, the mouse auditory ERP contains a positive deflection at approximately 80 ms following the N40, which we have termed the P80 (Figures 3c and 4a). After the P200, a novelty responsive component termed the P3 or P300 occurs in humans at approximately 300 ms (Ogura et al, 1991;Frodl et al, 1998). Similarly, the mouse P80 is followed by a peak that is augmented by novelty at approximately 120 ms, which we have called the P120 (Figure 4a).…”

Section: Discussionmentioning

confidence: 99%

“…These include the mismatch negativity, the P300 (also termed P3) and a novelty-elicited component occurring between 400 and 600 ms, termed the slow wave (Ford and Hillyard, 1981;Roth et al, 1981;Sams et al, 1983;Paavilainen et al, 1989;Ogura et al, 1991;Alho et al, 1998;Ceponiene et al, 1998;Escera et al, 1998;Schall et al, 1999;Spencer et al, 2001). Mismatch negativity is an automatic electroencephalographic response to change in stimulus characteristics such as tone or duration.…”

Section: Introductionmentioning

confidence: 99%

Effects of Strain, Novelty, and NMDA Blockade on Auditory-Evoked Potentials in Mice

Siegel

Connolly

Liang

et al. 2002

Neuropsychopharmacol

106

112

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People with schizophrenia exhibit impaired ability to modify electroencephalographic event-related potential (ERP) responses to novel stimuli. These deficits serve as a window into the abnormalities of neuronal organization and function and are thought to reflect a component of genetic vulnerability for schizophrenia. We describe differences among inbred mouse strains for ERPs following a novelty detection paradigm, as a model for genetic contributions to disease vulnerability. Auditory-evoked potentials were recorded during an auditory oddball task in nonanesthetized C57BL/6J, C3H/HeJ, and DBA/2J mice prior to and following ketamine (10 mg/kg). Stimuli consisted of 80 sets of 24 standard tones followed by one novel tone. Principal component analysis yielded four temporal components that contribute to the auditory ERP responses to standard and novel stimuli. Two principal components that varied between standard and novel stimuli also differed among inbred mouse strains. Post hoc analyses indicate that strain effects on novelty detection are due to a significant difference between the response to novel and standard tones in C3H/HeJ mice that is absent in the other two strains. Inbred strains of mice vary in their ability to perform neuronal detection of change in the auditory environment. The ability to model novelty detection deficits in mice will aid in identifying genetic contributions to abnormal neuronal organization in people with schizophrenia.

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“…In den meisten Studien konnte eine verminderte MMN bei schizophren Erkrankten belegt werden (Übersicht in ⊡ Tabelle 1), lediglich 5 der mittlerweile über 40 Studien zeigten keine signifikante Verminderung der MMN [18,23,24,36,37]. Da die Messwerte von Patienten und Kontrollen insgesamt stark überlappen, darf eine gewisse Anzahl von nicht positiven Befunden aus rein statistischen Gründen nicht verwundern.…”

Section: Befunde Zur Mmn In Der Schizophrenieforschungunclassified

“…In den meisten Studien konnte eine verminderte MMN bei schizophren Erkrankten belegt werden (Übersicht in ⊡ Tabelle 1), lediglich 5 der mittlerweile über 40 Studien zeigten keine signifikante Verminderung der MMN [18,23,24,36,37] [45], sodass man davon ausgehen muss, dass zumindest Teile der Gedächtnisspur auch länger als 10-15 s verfügbar sind.…”

Section: Befunde Zur Mmn In Der Schizophrenieforschungunclassified

Mismatch negativity in schizophrenia research

Rosburg

Kreitschmann-Andermahr

Sauer

2004

Nervenarzt

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Mismatch negativity (MMN) represents an event-related component of the auditory evoked potentials at about 100-250 ms, evoked by discernible changes in an ongoing uniform acoustic stimulation. The current paper reviews all recently published MMN studies in the field of schizophrenia research. A reduced MMN in schizophrenic patients is found in the majority of the studies. This deficit is likely to be related to the disorder, since antipsychotic medication seems to have little influence on these results. Interestingly, a reduced MMN is also found in first-degree relatives of patients. Clear evidence for a hemispheric lateralization of the MMN reduction in schizophrenic patients is lacking. A hypofunction of the N-methyl-D-aspartate (NMDA) receptor is discussed as a possible explanation of this deficit.

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Abnormalities in Event‐Related Potentials, N100, P200, P300 and Slow Wave in Schizophrenia

Cited by 35 publications

References 19 publications

Corticosterone Modulates Auditory Gating in Mouse

Corticosterone Modulates Auditory Gating in Mouse

Effects of Strain, Novelty, and NMDA Blockade on Auditory-Evoked Potentials in Mice

Mismatch negativity in schizophrenia research

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