Abnormalities of tooth development in pituitary dwarfism

The relationship between bone age, chronological age and dental age in children with isolated growth hormone deficiency

“…The effect of GH in dental development is not well understood, although it appears that development is retarded in the case of GHD [6,10–14]. When this deficit is treated the situation may either return to normal and dental age become almost equal to chronological age [12], or dental age may only improve slightly [15,16].…”

Prenatal expression of growth hormone receptor/binding protein and insulin-like growth factor-I (IGF-I) in the enamel organ

“…There is some clinical and animal evidence for a role of GH in tooth development (Sarnat et al 1988;Bigeard and Sommermater 1991). In children suffering pituitary dwarfism, some teeth fail to form or are smaller, and permanent teeth fail to erupt (Kosowiez and Rzymski 1977). Partanen and Thesleff (1987) and Abbot and Pratt (1988) have suggested that the EGF receptor plays a crucial role during tooth morphogenesis.…”

Oral manifestations in growth hormone disorders

“…The maxilla and mandible of affected patients are smaller than the normal and the face appears smaller[1–4] with the permanent teeth showing a delayed pattern of eruption. [35] Often the shedding pattern of deciduous teeth is delayed by several years, and also the development of roots of permanent teeth appears to be delayed. The dental arches are smaller than the normal and therefore cannot accommodate all the teeth resulting in dental malocclusion.…”

“…The complete absence of buds of the wisdom tooth even in the patient in fourth decade of life is also reported. [34] Other rare findings such as agenesis of the upper central incisor and solitary maxillary central incisor have been observed. [67] Amelogenesis imperfecta a diverse group of hereditary disorder that is characterized by defect in formation of tooth enamel has also been seen in the patient with reduced amount of growth hormone.…”