ABO blood group in primary antiphospholipid syndrome: influence in the site of thrombosis?

Nascimento, Natália Mastantuono; Bydlowski, Sérgio Paulo; Soares, R.P.S.; Andrade, Danieli; Bonfá, Eloísa; Seguro, Luciana Parente Costa; Borba, Eduardo F.

doi:10.1007/s11239-015-1176-8

Cited by 7 publications

(7 citation statements)

References 31 publications

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Section: Discussionmentioning

confidence: 99%

“…14 A recent investigation of patients with primary APS reported the association of non-O blood type with VTE and found elevated levels of vWF among patients with non-O blood type. 18 This association has been attributed to the influence of ABO blood groups on the secretion and clearance of vWF. ABO antigens present on vWF are believed to influence the clearance of upwards of 30% of vWF, and decreased levels of vWF are found in individuals with O blood type as compared to non-O blood type.…”

Section: Discussionmentioning

confidence: 99%

“…17 Furthermore, in one study of primary APS patients, vWF antigen and activity were higher in patients with non-O compared with O blood type. 18…”

Section: Introductionmentioning

confidence: 99%

“…17 Furthermore, in one study of primary APS patients, vWF antigen and activity were higher in patients with non-O compared with O blood type. 18 Therefore, we investigated the association between ABO blood type and VTE in patients with persistent aPL. We hypothesized that ABO blood type is an independent predictor and a potentially under-recognized risk factor for VTE in these individuals.…”

Section: Introductionmentioning

confidence: 99%

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The association between ABO blood types and venous thromboembolism in individuals with a positive antiphospholipid profile is varied by sex

Shusterman

Golub

Mowrey

et al. 2017

Lupus

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Objectives Although non-O blood type is an established risk factor for venous thromboembolism in the general population, the impact of ABO blood type (ABO) on venous thromboembolism risk in individuals with persistent antiphospholipid antibodies (aPL) has not been studied. We sought to investigate the relationship between ABO and venous thromboembolism in aPL-positive individuals. We also sought to explore potential interactions between ABO and sex or race to determine whether ABO contributes to race or sex differences with respect to the development of venous thromboembolism. Methods We identified all patients over 18 years old followed at a tertiary medical center between January 2000 and January 2015 with serological aPL criteria and ABO data. Episodes of venous thromboembolism were recorded. Logistic regression models were fitted to estimate odds ratios (ORs) of venous thromboembolism for non-O (A, B, or AB blood types) versus O blood type. Results There were 226 patients included in the final analysis, of whom 75 (33%) had reported venous thromboembolism. In the overall sample, there was a non-significant difference between venous thromboembolism in patients with non-O blood type compared to O blood type (OR 1.64, 95% confidence interval (CI) 0.94, 2.88; P = 0.08). Men with non-O blood type had a significantly higher risk of venous thromboembolism as compared to men with O-type blood (OR 4.94, 95% CI 1.37, 17.85; P = 0.02), but there was no significant association between ABO and venous thromboembolism among women (OR 0.96, 95% CI 0.50, 1.83; P = 0.52). Conclusions Non-O blood type may be an under-recognized risk factor for venous thromboembolism among men with persistent aPL antibodies, whereas the risk associated with non-O blood type seen in the general population may be attenuated in aPL-positive women.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…17 Furthermore, in one study of primary APS patients, vWF antigen and activity were higher in patients with non-O compared with O blood type. 18…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The association between ABO blood types and venous thromboembolism in individuals with a positive antiphospholipid profile is varied by sex

Shusterman

Golub

Mowrey

et al. 2017

Lupus

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“…26,27 Second, it has been widely described that non-O blood groups are closely related to VTD. 28,29 In our country, >85% of the general population is O-type but only 61% of our patients. In other words, non-O blood groups were more frequent in our patients versus the general population: 39% versus 15%, respectively.…”

Section: Discussionmentioning

confidence: 78%

Impact of Classical Risk Factors for Arterial or Venous Thrombosis in Patients With Antiphospholipid Syndrome

Navarro-Carpentieri

Castillo-Hernández

Majluf-Cruz

et al. 2017

Clin Appl Thromb Hemost

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There are classical risk factors associated with arterial thrombosis (AT) or venous thromboembolic disease (VTD). However, less is known about these risk factors and AT or VTD episodes in patients with antiphospholipid syndrome (APS). Our aim was to elucidate whether APS-related thrombotic episodes are associated with the same risk factors as the non-APS population. We gathered demographics, medical history, complications, and causes of death associated with the risk factors for AT or VTD in patients with APS. We analyzed 677 thrombotic events in 386 patients. Type 2 diabetes mellitus and grade 3 obesity were associated with VTD instead of AT. There were no significant differences between the groups for almost all laboratory tests analyzed, although lupus anticoagulant was significantly higher in the VTD group. We suggest that thrombosis in APS is due to the APS itself and that the risks factors for AT or VTD do not have a main role. Our findings may have an ethnical background. Therefore, it may be difficult to elaborate predictive thrombotic clinical scores applicable to patients with different ethnical background.

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Mechanisms of Action of the Antiphospholipid Antibodies

Chighizola

Raschi

Borghi

et al. 2017

Handbook of Systemic Autoimmune Diseases

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ABO blood group in primary antiphospholipid syndrome: influence in the site of thrombosis?

Cited by 7 publications

References 31 publications

The association between ABO blood types and venous thromboembolism in individuals with a positive antiphospholipid profile is varied by sex

The association between ABO blood types and venous thromboembolism in individuals with a positive antiphospholipid profile is varied by sex

Impact of Classical Risk Factors for Arterial or Venous Thrombosis in Patients With Antiphospholipid Syndrome

Mechanisms of Action of the Antiphospholipid Antibodies

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