Antiphospholipid syndrome (APS) is characterized by vascular thrombosis and/or obstetric complications associated with presence of antiphospholipid antibodies (aPL) but additional factors would also induce thrombosis. ABO (H) blood groups are known to be closely related to thrombosis, especially non-O blood type with venous events. The aim of this study was to investigate possible role of ABO (H) blood types in the thrombotic events in primary APS (PAPS). Seventy PAPS patients were selected for the study and were divided according to ABO blood group in: O PAPS (n = 26) and non-O PAPS (n = 44). ABO blood group phenotyping was performed by indirect technique. aPL anticardiolipin (aCL) and anti-βeta2 glycoprotein-1 (aβ2GPI) and the concentrations and activities of von Willebrand factor (VWF) were measured with ELISA. Lupus anticoagulant (LA) was detected by coagulation assays. A significant higher frequency of venous events was observed in non-O PAPS group (72.7 vs. 46.2 %, p = 0.040). In contrast, the frequency of arterial events was significantly higher in the O PAPS compared to the non-O PAPS group (69.2 vs. 36.4 %, respectively; p = 0.013). Frequencies of aCL, LA, aβ2GPI and triple aPL positivity were similar in both groups (p > 0.05). VWF antigen (75.54 ± 8.68 vs. 79.51 ± 7.07 IU/dl, p = 0.041) and activity (70.23 ± 11.96 vs. 77.92 ± 13.67 %, p = 0.020) were decreased in O PAPS compared to non-O blood group. VWF:CB/VWF:Ag ratio was similar among groups (p > 0.05). This is the first report that confirms the role of ABO blood system in thrombosis of PAPS and suggests that non-O blood group was related with venous events and O blood group with arterial thrombosis.
À equipe de enfermagem da enfermaria do quinto andar e da REC-I do InCor pelo auxílio prestado durante as coletas. Aos membros da banca de qualificação, Dra. Juliana Pereira, Dra. Vânia Maris Morelli e Prof. Dr. Antônio Augusto Barbosa Lopes por todas as importantíssimas sugestões feitas a esta dissertação. À querida Dra. Maria Aparecida Basile por todas as suas sugestões, pelo exemplo de amor ao ensino e por tudo o que aprendi durante sua disciplina e estágio supervisionado, e claro, por nossa amizade. À amiga Cleidinha, Cleide Menarbini Appolonio por sua importantíssima ajuda na finalização deste trabalho, e principalmente por seu carinho. À querida amiga Ná, Edna Ferreira da Silva, minha segunda mãe, por sempre me encorajar nos momentos mais difíceis da vida, por suas constantes palavras de carinho, por se dedicar ao máximo para que eu tivesse uma excelente educação, e principalmente por seu carinho e amor. Aos queridos amigos Kelly Bonamini e Gustavo Barroso, que acompanharam esta jornada desde o início, pelas constantes palavras de conforto e carinho, e por nossa amizade. Aos meus dois companheiros de aprendizagem na bancada, João Henrique e Fernando Vilela, pelo carinho e amizade. À querida Bruninha, Bruna Trevisani, que me trouxe novas energias nos momentos mais tensos da escrita desta dissertação, pelo seu carinho e por nossa amizade. Ao Magna, Antônio Carlos Magnanelli, por ter me passado um pouco do seu conhecimento sobre cálculos e preparo de soluções e por suas sugestões. Ao querido Joel, Joel Marques Bispo, por estar sempre de prontidão para me auxiliar no que fosse preciso, pelo seu carinho e por nossa amizade.
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