ABO blood group, secretor status and detection of<i>Helicobacter pylori</i>among patients with gastric or duodenal ulcers

Mentis, Αndreas; Blackwell, C. C.; Weir, D. M.; Spiliadis, C.; Dailianas, Apostolos; Skandalis, N.

doi:10.1017/s0950268800048366

Cited by 93 publications

(65 citation statements)

References 32 publications

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“…The distribution of the ABO blood group phenotypes did not differ between the two camps and were similar to those we found in a previous study [16] and that reported by Hirzfeld and Hirzfeld in 1919 [17]. Several of the factors examined in the study varied between the two camps.…”

Section: Discussionsupporting

confidence: 89%

Factors affecting carriage of Neisseria meningitidis among Greek military recruits

et al. 1992

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SUMMARYGreek military recruits (993) were examined for carriage of meningococci during July 1990. Blood, saliva and throat swab specimens were obtained and each recruit answered a questionnaire providing information on age, education (a measure of socioeconomic level), place of residence, smoking habits and recent infections.The overall carriage rate was 25 % but differed between the two camps: 79/432 (18%) in Camp A and 168/561 (30%) in Camp B (P < 0-0005). In Camp B, there were significantly higher proportions of recruits who were non-secretors (P < 0 0005), and/or heavy smokers (P < 0-0005). They were also younger (< 19 years old) (P < 0-001), and on the whole had fewer years of education (P < 0-0005). By univariate analysis, carriage was significantly associated with smoking. By multiple logistic regression analysis, carriage was associated with smoking (P < 0-001), age (P < 0-01) and the camp in which the recruits were based (P < 0-01). Among recruits in Camp B, 15/38 (40%) of those with recent viral infections were carriers compared with 30 % for the camp in general.

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Section: Discussionsupporting

confidence: 89%

Factors affecting carriage of Neisseria meningitidis among Greek military recruits

et al. 1992

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“…Individuals with blood group O were found to be more susceptible to peptic ulcer disease for decades without known cause until the relationship between Lewis b antigens and the attachment of H. pylori to gastric mucosa was observed (11)(12)(13). However, the correlation between H. pylori infection and ABO blood types was not supported in some reports (14)(15).…”

Section: Discussionmentioning

confidence: 99%

“…People with blood group O have been noted to be more susceptible to peptic ulcer disease for decades without appropriate explanations (11). In 1993, Boren et al (12) reported that people with blood group O had more H. pylori receptors, and Lewis b antigens mediated the attachment of H. pylori to the gastric mucosa.…”

Section: Introductionmentioning

confidence: 99%

Serioprevalence of <i>Helicobacter pylori</i> Infection in and its Relationship with ABO Blood Groups

Tadege¹,

Mengistu²,

Desta³

et al. 2005

Ethiopian Journal of Health Development

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Background: Helicobacter pylori infection occurs worldwide, but the prevalence varies greatly among countries and among population groups studied. People with blood group O have been noted to be more susceptible to H. pylori infection. Objectives: To determine the magnitude of H. pylori infection in adult patients with and without dyspeptic symptoms attending Felege Hiwot Hospital, Bahir Dar, North West Ethiopia. We also prospectively examined the relationship between H. pylori infection and ABO blood groups in those subjects to clarify the possible association. Methods: A case-control study was conducted between dyspeptic (n=100) and non-dyspeptic patients (n=100) for the presence of H. pylori infection between mid November 2002 and March 2003 by using serology. Results: Of the total 200 subjects, 128 (64%) were males and 72 (36%) females with mean age of 32.7, range 15-75, years. Of these, 112 (56%) and 66 (33%) were found positive and negative for H. pylori infection, respectively, by EIA. Borderline values were measured in 22/200 (11%). H. pylori infection was detected in 124/200 (62%) of study subjects by immunoblot. The most prevalent blood group was type O (43%), followed by A (23.5%), B (22.5%) and AB (11%). In comparison of the subjects with blood group O and the other blood groups, no statistical significance could be identified in the seroprevalence of H. pylori ( p>0.05). Conclusion:The overall seroprevalence of H. pylori infection in Bahir Dar in this study was between 63% and 70% in dyspeptic patents and 49% and 54% in non-dyspeptic patients by EIA and IB, respectively. There were no statistically significant differences in the frequency of H. pylori seroprevalence between dyspeptic and non-dyspeptic patients. There was no statistically significant association between H. pylori infection and sex, age and ABO blood groups. Thus, further investigations along this line are recommended. [Ethiop.J.Health Dev. 2005;19(1):55-59]

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“…The nonsecretor status of this individual is interesting in view of the increased prevalence of duodenal ulcer among non-secretors (47)(48)(49). One study (50) has demonstrated that non-secretion is not associated with increased susceptibility to infection with H. pylori.…”

Section: Discussionmentioning

confidence: 99%

Lactotetraosylceramide, a Novel Glycosphingolipid Receptor for Helicobacter pylori, Present in Human Gastric Epithelium

Teneberg

Leonardsson

Karlsson

et al. 2002

Journal of Biological Chemistry

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The binding of Helicobacter pylori to glycosphingolipids was examined by binding of 35 S-labeled bacteria to glycosphingolipids on thin-layer chromatograms. In addition to previously reported binding specificities, a selective binding to a non-acid tetraglycosylceramide of human meconium was found. This H. pylori binding glycosphingolipid was isolated and, on the basis of mass spectrometry, proton NMR spectroscopy, and degradation studies, were identified as Gal␤3GlcNAc␤3-Gal␤4Glc␤1Cer (lactotetraosylceramide). When using non-acid glycosphingolipid preparations from human gastric epithelial cells, an identical binding of H. pylori to the tetraglycosylceramide interval was obtained in one of seven samples. Evidence for the presence of lactotetraosylceramide in the binding-active interval was obtained by proton NMR spectroscopy of intact glycosphingolipids and by gas chromatography-electron ionization mass spectrometry of permethylated tetrasaccharides obtained by ceramide glycanase hydrolysis. The lactotetraosylceramide binding property was detected in 65 of 74 H. pylori isolates (88%). Binding of H. pylori to lactotetraosylceramide on thin-layer chromatograms was inhibited by preincubation with lactotetraose but not with lactose. Removal of the terminal galactose of lactotetraosylceramide by galactosidase hydrolysis abolished the binding as did hydrazinolysis of the acetamido group of the Nacetylglucosamine. Therefore, Gal␤3GlcNAc is an essential part of the binding epitope.Adhesion of microorganisms to target cells is regarded as a first step in pathogenesis of infections, where the specificity of the adhesins of the infectious agent on the one hand and the receptor structures expressed by the epithelial cells of the host target organ on the other are important determinants of the host range and the tissue tropism of the pathogen (1).The human gastric pathogen Helicobacter pylori is an etiologic agent of chronic active gastritis, peptic ulcer disease, and gastric adenocarcinoma (2, 3). This Gram-negative bacterium has a very distinct host range and tissue tropism, i.e. it requires human gastric epithelium for colonization (4). In the human stomach most of the bacteria are found in the mucus layer (5), but selective association of the bacteria to surface mucous cells has also been shown (4, 6).Several different binding specificities of H. pylori have previously been demonstrated. Thus, the binding of the bacterium to such diverse compounds as phosphatidylethanolamine and gangliotetraosylceramide (7), the Le b blood group determinant (8), heparan sulfate (9), the GM3 1 ganglioside and sulfatide (10, 11), and lactosylceramide (12), has been reported. A sialic aciddependent binding of H. pylori to large complex glycosphingolipids (polyglycosylceramides) has also been documented (13). However, only one H. pylori adhesin, the Le b binding BabA adhesin, has been identified to date (14).In the present study a number of different H. pylori strains were labeled with [35 S]methionine and examined for binding to a panel of...

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ABO blood group, secretor status and detection ofHelicobacter pyloriamong patients with gastric or duodenal ulcers

Cited by 93 publications

References 32 publications

Factors affecting carriage of Neisseria meningitidis among Greek military recruits

Factors affecting carriage of Neisseria meningitidis among Greek military recruits

Serioprevalence of <i>Helicobacter pylori</i> Infection in and its Relationship with ABO Blood Groups

Lactotetraosylceramide, a Novel Glycosphingolipid Receptor for Helicobacter pylori, Present in Human Gastric Epithelium

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