Abolishment of Spontaneous Flight Turns in Visually Responsive Drosophila

Ferris, Bennett Drew; Green, Jonathan; Maimon, Gaby

doi:10.1016/j.cub.2017.12.008

Cited by 27 publications

(23 citation statements)

References 59 publications

(89 reference statements)

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“…Across stimulus intensities and spatial configurations, we found that turn dynamics reflected both mechanosensory and visual input; antennal stabilization experiments argue that these signals are integrated within the brain. Although integration of both modalities was visible in nearly every stimulus configuration we tested, unexpected turns also occurred in many of our experiments, suggesting that the integrative process on which we have focused must coexist with mechanisms to generate stochastic turns [7,29,30]. …”

Section: Discussionmentioning

confidence: 96%

Multisensory Control of Orientation in Tethered Flying Drosophila

Currier

Nagel

2018

Current Biology

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Summary A longstanding goal of systems neuroscience is to quantitatively describe how the brain integrates sensory cues over time. Here we develop a closed-loop orienting paradigm in Drosophila to study the algorithms by which cues from two modalities are integrated during ongoing behavior. We find that flies exhibit two behaviors when presented simultaneously with an attractive visual stripe and aversive wind cue. First, flies perform a turn sequence where they initially turn away from the wind and but later turn back toward the stripe, suggesting dynamic sensory processing. Second, turns toward the stripe are slowed by the presence of competing wind, suggesting summation of turning drives. We develop a model in which signals each modality are filtered in space and time to generate turn commands, then summed to produce ongoing orienting behavior. This computational framework correctly predicts behavioral dynamics for a range of stimulus intensities and spatial arrangements.

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Section: Discussionmentioning

confidence: 96%

Multisensory Control of Orientation in Tethered Flying Drosophila

Currier

Nagel

2018

Current Biology

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“…Mitochondria are vital in regulating cellular adaption to stressors, including impaired biogenesis, mitochondrial DNA (mtDNA) damage, ageing, nutrient restriction and aberrant imbalances between fission and fusion events. If left unchecked, these processes can cause damage to nucleic acids, lipids and proteins through ROS, resulting in sustained oxidative stress [ 16 , 17 ]. Oxidative stress modulates mitochondrial dynamics through posttranscriptional modifications, including ubiquitination [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

PINK1/PARKIN signalling in neurodegeneration and neuroinflammation

Quinn

Moreira

Ambrósio

et al. 2020

acta neuropathol commun

280

136

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Mutations in the PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN) genes are associated with familial forms of Parkinson’s disease (PD). PINK1, a protein kinase, and PARKIN, an E3 ubiquitin ligase, control the specific elimination of dysfunctional or superfluous mitochondria, thus fine-tuning mitochondrial network and preserving energy metabolism. PINK1 regulates PARKIN translocation in impaired mitochondria and drives their removal via selective autophagy, a process known as mitophagy. As knowledge obtained using different PINK1 and PARKIN transgenic animal models is being gathered, growing evidence supports the contribution of mitophagy impairment to several human pathologies, including PD and Alzheimer’s diseases (AD). Therefore, therapeutic interventions aiming to modulate PINK1/PARKIN signalling might have the potential to treat these diseases. In this review, we will start by discussing how the interplay of PINK1 and PARKIN signalling helps mediate mitochondrial physiology. We will continue by debating the role of mitochondrial dysfunction in disorders such as amyotrophic lateral sclerosis, Alzheimer’s, Huntington’s and Parkinson’s diseases, as well as eye diseases such as age-related macular degeneration and glaucoma, and the causative factors leading to PINK1/PARKIN-mediated neurodegeneration and neuroinflammation. Finally, we will discuss PINK1/PARKIN gene augmentation possibilities with a particular focus on AD, PD and glaucoma.

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“…The short bar saccade rate was higher than previously reported spontaneous saccade rates in the magnetic tether (∼0.4 saccades s −1 ) (Bender and Dickinson, 2006;Mongeau and Frye, 2017), suggesting that the short bar stimulus elicited visually guided saccades. However, we expect that some saccades we measured were spontaneous, triggered by endogenous processes (Ferris et al, 2018;Schnell et al, 2017). Nevertheless, there was a significant association between the stimulus type and saccade valence (χ 2 test, P<0.001, d.f.=1, n=2833 saccades).…”

Section: Resultsmentioning

confidence: 82%

Visuomotor strategies for object approach and aversion in Drosophila melanogaster

Mongeau

Cheng

Aptekar

et al. 2018

Journal of Experimental Biology

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Animals classify stimuli to generate appropriate motor actions. In flight, Drosophila melanogaster classify equidistant large and small objects with categorically different behaviors: a tall object evokes approach whereas a small object elicits avoidance. We studied visuomotor behavior in rigidly and magnetically tethered D. melanogaster to reveal strategies that generate aversion to a small object. We discovered that small-object aversion in tethered flight is enabled by aversive saccades and smooth movement, which vary with the stimulus type. Aversive saccades in response to a short bar had different dynamics from approach saccades in response to a tall bar and the distribution of pre-saccade error angles was more stochastic for a short bar. Taken together, we show that aversive responses in D. melanogaster are driven in part by processes that elicit signed saccades with distinct dynamics and trigger mechanisms. Our work generates new hypotheses to study brain circuits that underlie classification of objects in D. melanogaster.

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Abolishment of Spontaneous Flight Turns in Visually Responsive Drosophila

Cited by 27 publications

References 59 publications

Multisensory Control of Orientation in Tethered Flying Drosophila

Multisensory Control of Orientation in Tethered Flying Drosophila

PINK1/PARKIN signalling in neurodegeneration and neuroinflammation

Visuomotor strategies for object approach and aversion in Drosophila melanogaster

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