Abortive rabies in rabbits and white rats infected intracerebrally

Gribencha, S. V.

doi:10.1007/bf01318240

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…In another report, two of the dogs, inoculated with a rabies virus strain from Ethiopia recovered from clinical rabies [27]. In other words, rabies carrier state or inapparent infection and the presence of rabies antigens and antibodies in apparently healthy dogs have been a subject of research in Nigeria and elsewhere in the world [16,20,21,22,23,28,29,30,31]. Additional research, however, is necessary to answer these questions.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Direct Rapid Immunohistochemistry Test for Rabies Diagnosis in the Brain of Slaughtered Dogs in Northern Nigeria

Garba

Modupe

Dzikwi

et al. 2015

AIR

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Section: Discussionmentioning

confidence: 99%

Evaluation of Direct Rapid Immunohistochemistry Test for Rabies Diagnosis in the Brain of Slaughtered Dogs in Northern Nigeria

Garba

Modupe

Dzikwi

et al. 2015

AIR

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“…When recovery has occurred, the majority of cases were left with permanent neurologic sequelae and severe cognitive disability [79]. In experimental infection of animals, recovery has been recorded in a number of species, including mice [17,66,80], dogs [81], a ferret [82], and rabbits [83]. As with human cases, the majority of these individuals had lasting sequelae following recovery.…”

Section: Recoverymentioning

confidence: 99%

Rabies virus-neutralising antibodies in healthy, unvaccinated individuals: What do they mean for rabies epidemiology?

et al. 2020

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Rabies has been a widely feared disease for thousands of years, with records of rabid dogs as early as ancient Egyptian and Mesopotamian texts. The reputation of rabies as being inevitably fatal, together with its ability to affect all mammalian species, contributes to the fear surrounding this disease. However, the widely held view that exposure to the rabies virus is always fatal has been repeatedly challenged. Although survival following clinical infection in humans has only been recorded on a handful of occasions, a number of studies have reported detection of rabies-specific antibodies in the sera of humans, domestic animals, and wildlife that are apparently healthy and unvaccinated. These 'seropositive' individuals provide possible evidence of exposure to the rabies virus that has not led to fatal disease. However, the variability in methods of detecting these antibodies and the difficulties of interpreting serology tests have contributed to an unclear picture of their importance. In this review, we consider the evidence for rabies-specific antibodies in healthy, unvaccinated individuals as indicators of nonlethal rabies exposure and the potential implications of this for rabies epidemiology. Our findings indicate that whilst there is substantial evidence that nonlethal rabies exposure does occur, serology studies that do not use appropriate controls and cutoffs are unlikely to provide an accurate estimate of the true prevalence of nonlethal rabies exposure.

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“…To achieve this goal, a joint project of WHO–OIE–FAO was announced in 2015 to control animal–human–ecosystems rabies interface [5] , [20] , [21] , [22] . It was previously suggested that different forms of rabies infections exist in nature according to the invading virus [23] . While infection with paralytic rabies virus (PRV) results in dog paralysis within 6 days, the convulsive rabies viruses (CRV) induces convulsions in dogs after a longer incubation period [24] .…”

Section: History Distribution and Transmission Of The Diseasementioning

confidence: 99%

Advances in rabies prophylaxis and treatment with emphasis on immunoresponse mechanisms

El-Sayed

2018

International Journal of Veterinary Science and Medicine

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Rabies is a vaccine-preventable fatal disease in man and most mammals. Although rabies is recorded in 150 territories and is responsible for at least 60,000 human deaths every year worldwide, it is a neglected tropical problem. Most of the rabies free countries are considered to be fragile free as the disease may re-emerge easily through wild mammals. For the performance of effective rabies eradication programs, a complex set of strategies and activities is required. At the time, a joint project of WHO–OIE–FAO which was announced in 2015, plans to control animal–human–ecosystems rabies interface. For effective rabies control, prophylactic policies must be applied. These include various educational outreaches for farmers and people living in endemic areas, enforced legislation for responsible dog ownership, control programs for the free-ranging stray dog and cat populations, field large-scale vaccination campaigns, and the development of new vaccine delivery strategies for both humans and animals. The present work presents the advances in the development of new safe, effective and economic vaccines for domestic dogs, and oral vaccines for the control of the disease in wild animals. It presents also some therapeutic protocols used for the treatment of patients.

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Abortive rabies in rabbits and white rats infected intracerebrally

Cited by 4 publications

References 6 publications

Evaluation of Direct Rapid Immunohistochemistry Test for Rabies Diagnosis in the Brain of Slaughtered Dogs in Northern Nigeria

Evaluation of Direct Rapid Immunohistochemistry Test for Rabies Diagnosis in the Brain of Slaughtered Dogs in Northern Nigeria

Rabies virus-neutralising antibodies in healthy, unvaccinated individuals: What do they mean for rabies epidemiology?

Advances in rabies prophylaxis and treatment with emphasis on immunoresponse mechanisms

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