Abrupt bilateral blindness as a rare post-acute demyelinating consequence of COVID-19

Motahharynia, Ali; Naghavi, Saba; Shaygannejad, Vahid; Adibi, Iman

doi:10.1016/j.ensci.2022.100411

Cited by 5 publications

(7 citation statements)

References 16 publications

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“…Guillain-Barré and Miller-Fisher syndromes (types of autoimmune damage in CNS) have been diagnosed in COVID-19 patients (Verkhratsky et al, 2020). After the pandemic, the incidence of many inflammatory and autoimmune diseases in CNS elevated as an immunological consequence of COVID-19 as; autoimmune encephalitis, acute disseminated encephalomyelitis (ADEM), multiple sclerosis, postinfection-acute demyelination, and neuromyelitis optica spectrum disorder (NMOSD) (Motahharynia et al, 2022;Naser Moghadasi, 2021;Novi et al, 2020). The scientific community has hypothesised that autoimmune disorders of the central nervous system linked to COVID-19 (CRAD-C) would be unique and different from disorders unrelated to COVID-19.…”

Section: Autoimmunitymentioning

confidence: 99%

“…The case was a 96-year-old woman with previous SARS-CoV-2 infection, and MRI showed demyelination and hyperintense lesion in the white matter. They interpret the case as a COVID-19related autoimmune disorder of the central nervous system (CRAD-C) (Motahharynia et al, 2022). An Italian 64-year-old woman had bilateral vision impairment and loss of sensation in her right leg after a month of SARS-CoV-2 infection (Novi et al, 2020).…”

Section: Autoimmunitymentioning

confidence: 99%

“…An Italian 64-year-old woman had bilateral vision impairment and loss of sensation in her right leg after a month of SARS-CoV-2 infection (Novi et al, 2020). Clinical investigations of both vision disorder cases showed that COVID-19related neuromyelitis optical differs from the atypical form of the same disorders as the absence of antiaquaporin-4 (anti-AQ4) or antimyelin oligodendrocyte glycoprotein (anti-MOG) antibodies in the serum of COVID-19-related cases (Motahharynia et al, 2022;Novi et al, 2020).…”

Section: Autoimmunitymentioning

confidence: 99%

See 2 more Smart Citations

COVID-19 and the central nervous system: What is the interplay?

El‐Fadeal¹,

Anber²,

Elkot³

et al. 2022

Neurosci Res Notes

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Since the outbreak of COVID-19 in 2019-2020, the highly contiguous disease caused by coronavirus 2 (SARS-CoV-2) spread worldwide in a short life span causing a disastrous effect and nearly 5.8 million deaths until February 2022. This global health crisis caused concerns about the disease's aetiology, epidemiology, and management. Understanding the virus's long- and short-term consequences on diverse human body organs and systems was one of the scientist's concerns despite the virus' respiratory system principal effect. Thus, after reporting neurological symptoms in approximately one-third of hospitalised patients with COVID-19, demonstrating how COVID-19 infects the central nervous system (CNS), causing neurodegenerative diseases in various patients and how the virus affects CNS function became quintessential. There are various mechanisms for COVID-19 pathophysiology, some implicating the potential virus invasion of the blood-brain barrier (BBB). Trans-synaptic and hematogenous routes are the main routes for the virus to pass through the barrier. Binding to the BBB endothelial cells is causing significant alterations in the permeability and integrity properties of the barrier, which cause an elevation of the incidence rate of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis among COVI-19 patients. COVID-19 patients developed neurological manifestations ranging from mild symptoms to severe diseases such as headache and loss of smell, encephalitis and CNS-mediated respiratory distress. However, encephalitis is not a common complication, and it has a significant mortality rate in severely ill patients due to the hyperactivation of the host immune response. Although more investigations are needed, severe COVID- 19 patients are considered at a high risk of neurodegenerative disorder as a long-term consequence of SARS-CoV-2 infection.

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Section: Autoimmunitymentioning

confidence: 99%

Section: Autoimmunitymentioning

confidence: 99%

Section: Autoimmunitymentioning

confidence: 99%

See 1 more Smart Citation

COVID-19 and the central nervous system: What is the interplay?

El‐Fadeal¹,

Anber²,

Elkot³

et al. 2022

Neurosci Res Notes

View full text Add to dashboard Cite

show abstract

“…At present, there is no universally accepted definition, but this health issue is being termed as the "post-acute COVID-19 syndrome" or the "long COVID-19." This review provides a brief descriptive and qualitative summary of the presently researched, studied and health issues of post-acute COVID-19 syndrome which is usually a disease seen in people that recovered from a bout of COVID-19 infection but continue to have health issues [10][11][12][13][14][15][16][17][18].…”

Section: What Is Post-acute Covid-19 Syndrome?mentioning

confidence: 99%

A New Phenomenon: Post-Acute COVID-19 Syndrome

Sharma¹

2022

IJOPRS

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During the last two and half years, the world continues to face public health challenges created by the wave upon wave of COVID-19 (coronavirus disease 2019) infections in the currently ongoing pandemic (being started with the emergence of new, mutated and more transmissible strains of the COVID-19 virus). In the aftermath of the successive waves of the COVID-19 pandemic, many COVID-19 survivors have presented with what has been termed "post-acute COVID-19 syndrome" or "long-term COVID-19." There is an urgent requirement of both a universal framework for recognizing at risk patients for post-acute COVID-19 syndrome and the provision of multidisciplinary care in targeted COVID-19 outpatient facilities.

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“…Interestingly, in the case of the SARS-CoV-2, only rare extreme cases of blindness and sensory damages, such as conjunctivitis, optic neuritis or dry eyes, have been reported, with a low frequency (up to 25% vs. 80% for anosmia and ageusia). Moreover, these symptoms appear late in the course of the viral infection, and they are of reduced severity compared to the ones observed in the senses of chemical perception [ 10 , 11 , 12 , 13 ]. One of the main reasons for this divergence lies in the interaction of SARS-CoV-2 with its host cells.…”

Section: Introductionmentioning

confidence: 99%

Ocular Symptoms Associated with COVID-19 Are Correlated with the Expression Profile of Mouse SARS-CoV-2 Binding Sites

Brechbühl

Ferreira

Lópes

et al. 2023

Viruses

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The COVID-19 pandemic has engendered significant scientific efforts in the understanding of its infectious agent SARS-CoV-2 and of its associated symptoms. A peculiar characteristic of this virus lies in its ability to challenge our senses, as its infection can lead to anosmia and ageusia. While ocular symptoms, such as conjunctivitis, optic neuritis or dry eyes, are also reported after viral infection, they have lower frequencies and severities, and their functional development is still elusive. Here, using combined technical approaches based on histological and gene profiling methods, we characterized the expression of SARS-CoV-2 binding sites (Ace2/Tmprss2) in the mouse eye. We found that ACE2 was ectopically expressed in subtissular ocular regions, such as in the optic nerve and in the Harderian/intraorbital lacrimal glands. Moreover, we observed an important variation of Ace2/Tmprss2 expression that is not only dependent on the age and sex of the animal, but also highly heterogenous between individuals. Our results thus give new insight into the expression of SARS-CoV-2 binding sites in the mouse eye and propose an interpretation of the human ocular-associated symptoms linked to SARS-CoV-2.

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Abrupt bilateral blindness as a rare post-acute demyelinating consequence of COVID-19

Cited by 5 publications

References 16 publications

COVID-19 and the central nervous system: What is the interplay?

COVID-19 and the central nervous system: What is the interplay?

A New Phenomenon: Post-Acute COVID-19 Syndrome

Ocular Symptoms Associated with COVID-19 Are Correlated with the Expression Profile of Mouse SARS-CoV-2 Binding Sites

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