Abscopal complete regression of hepatocellular carcinoma with multiple pleural metastases

Ohmatsu, Kenta; Hashimoto, Y.; Kawanishi, Miki; Ishii, Y.; Sawa, Kôichiro; Kuribayashi, Shigehiko; Ariizumi, Shun‐ichi; Karasawa, Kumiko

doi:10.1007/s13691-020-00446-y

Cited by 13 publications

(6 citation statements)

References 16 publications

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“…As of December 2022, only five cases describing an abscopal effect in HCC had been reported (11,(22)(23)(24)(25). All cases involved middle-aged or older men; however, no other common features were identified.…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular Carcinoma Showing Tumor Shrinkage Due to an Abscopal Effect

et al. 2024

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We herein report a 63-year-old man who presented with left lower jaw pain and was diagnosed with hepatocellular carcinoma with bone metastases post-examination. All tumors grew after immunotherapy with atezolizumab and bevacizumab, and his jaw pain worsened. After palliative radiation therapy, however, the tumors shrank markedly, with no recurrence seen after stopping immunotherapy. To our knowledge, this is the first case in which a radiotherapy-and immunotherapy-mediated abscopal effect facilitated tumor shrinkage and immunotherapy discontinuation.

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Section: Discussionmentioning

confidence: 99%

Hepatocellular Carcinoma Showing Tumor Shrinkage Due to an Abscopal Effect

et al. 2024

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“…However, immunotherapy compensates for this rarity. Multiple clinical and pre-clinical studies (Table I) have shown that, compared with the effect of radiotherapy or immunotherapy alone, the combination of radiotherapy and immunotherapy can significantly increase the incidence and intensity of the abscopal effect (7,13,(163)(164)(165)(166). Commonly used immune checkpoint inhibitors are anti-CTLA-4, anti-PD-1 and anti-PD-L1 antibodies, all of which strengthen the effect of T cells on tumor cells and can be combined with radiotherapy to enhance the incidence rate of the abscopal effect.…”

Section: Clinical Applicationmentioning

confidence: 99%

Mechanism of exosomes in the tumor microenvironment in the abscopal effect (Review)

et al. 2022

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Previously, the abscopal effect, which is an antitumor therapeutic effect on untreated tumor locations elsewhere in the body as a result of treatment of the targeted region, was rarely reported, and its mechanism remains unknown. Increasing evidence has shown that the immune system is implicated in the abscopal effect, and that combining immunotherapy and radiation can assist to improve its frequency. Understanding how different types of cells and cell-derived exosomes cause the abscopal effect in the tumor microenvironment (TME) is crucial to increasing the clinical occurrence of the abscopal effect in the TME. Contents 1. Introduction 2. Immune mechanism of the abscopal effect 3. Role of tumor cells 4. Roles of tumor-associated molecular patterns 5. Clinical application 6. Conclusions

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“…As with other radiation-based treatment modalities synergistic effects, often referred to as the abscopal effect, have been put forward as a pathophysiological basis for this approach [92, 93]. To date, only experimental data and case reports are available on this matter in HCC, but early clinical trials have already been initiated (NCT03380130) [94, 95].…”

Section: Yttrium-90 Radioembolization/sirtmentioning

confidence: 99%

Advances in Diagnostic and Interventional Radiology in Hepatocellular Carcinoma

Öcal

Rössler

Ricke

et al. 2021

Dig Dis

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Background: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths, and radiological imaging and locoregional therapies are essential for the management of patients with HCC. Summary: In cirrhotic patients, a characteristic imaging pattern establishes the noninvasive diagnosis of HCC with acceptable sensitivity and high specificity. In addition to diagnosis, imaging is used in the staging of patients and treatment allocation. Multiparametric MRI with hepatospecific contrast agents improves lesion detection, characterization, and treatment allocation; recently described imaging criteria allow identification of precursor lesions. Radiofrequency ablation (RFA) and transarterial chemoembolization (TACE) have been established in the treatment of patients with HCC at the early and intermediate stages, respectively. Microwave ablation has been described as an alternative to RFA in selected cases. Imaging-guided brachytherapy, a catheter-based radiotherapy technique, offers advantages to overcome some limitations of the aforementioned therapies, including the tumor location and size. Currently, no adjuvant therapy is recommended after RFA or TACE, but several new drugs are under evaluation. Furthermore, although the exact role of selective internal radiation therapy (SIRT) in HCC still needs to be defined, it is an alternative to systemic agents in patients with intolerance, and additional benefit has been shown in selected subgroups. Additionally, SIRT offers an alternate to TACE with higher objective response rates in patients who needs bridging before transplantation. Key Messages: New imaging criteria improved lesion detection in patients at a risk for HCC, and advances in interventional therapies expanded the range of patients eligible for locoregional treatments.

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Abscopal complete regression of hepatocellular carcinoma with multiple pleural metastases

Cited by 13 publications

References 16 publications

Hepatocellular Carcinoma Showing Tumor Shrinkage Due to an Abscopal Effect

Hepatocellular Carcinoma Showing Tumor Shrinkage Due to an Abscopal Effect

Mechanism of exosomes in the tumor microenvironment in the abscopal effect (Review)

Advances in Diagnostic and Interventional Radiology in Hepatocellular Carcinoma

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