Absence of a radiation-induced adaptive response of lymphocytes in Down's syndrome

Khandogina, E.K.; Mutovin, G.R.; Zvereva, S.V.; Zverev, D.O.; Neudakhin, E.V.; Arkhipov, B. A.; Akif'ev, A. P.

doi:10.1007/bf00840613

Cited by 5 publications

(4 citation statements)

References 8 publications

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“…Examining the Down syndrome, Khandogina et al [79] showed some association between RAR and DNA repair. In all of the examined patients with the Down syndrome, which is characterized by radiosensitivity, lymphocytes lacked RAR.…”

Section: Adaptive Responsementioning

confidence: 98%

Mechanisms of human cell protection associated with genetic polymorphism

Zasukhina

2005

Russ J Genet

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Systems ensuring protection of human cells against endogenous and exogenous mutagenic factors are considered in terms of genetic polymorphism. Some protection mechanisms are described, including those connected with capturing free radicals, biotransformation of xenobiotics, excision repair of DNA damage (excision of nitrous bases, nucleotides, mismatch repair). A special section is devoted to some issues of using antimutagens in context of genetic polymorphism. The problem of adaptive response is discussed, providing evidence for independence (in some cases) of DNA repair systems and the formation of adaptive response. Some results of the author obtained many years ago but still relevant are presented.

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Section: Adaptive Responsementioning

confidence: 98%

Mechanisms of human cell protection associated with genetic polymorphism

Zasukhina

2005

Russ J Genet

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“…These observations reveal the following tendencies: abnormal chromosome patterns are encountered more frequently among residents of more contaminated territories or in subjects with higher thyroid doses. Other authors have reported such tendencies as well [17,18].…”

mentioning

confidence: 67%

Analysis of Chromosome Lesions in Women with Benign Breast Diseases, Residing in the Territories Contaminated as a Result of the Chernobyl Accident

Иванова

Смирнова

Kondrashova

et al. 2005

KEM

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Spontaneous levels of the chromosome aberrations in the peripheral lymphocytes of 173 women were analyzed in the course of a medical examination of the residents of the Bryansk District territories (Klintsy Region, and the town of Klintsy) contaminated after the Chernobyl NPP accident in April 1986. The study population included only women who had been premenopausal at the time of the accident (mean age in 1986 was 23.9±0.7 years, ranging 2 to 56 years). The territory contamination with 137Cs ranged from 1.8 to 23.7 Ci/km2, the mean value being 7.5±0.2 Ci/km2. The range of the calculated absorbed thyroid doses was 30 to 340 mGy (in average, 52.3±3.3 mGy). The number of women with benign breast diseases (BBD) was 116 (67%). All recognizable chromosome lesion types were scored in the first in vitro division metaphases stained with azure-eosin. The mean total aberration frequency in the sample studied was 3.5±0.2 per 100 metaphases, the main contribution being made by the chromatid deletions, which is typical for a normal spontaneous aberration pattern. Based on the results of the cytogenetic analysis, the study population was subdivided into two groups. Group A (128 women) included subjects who showed normal patterns of spontaneous chromosome aberrations. Abnormal patterns, including the aberration frequencies significantly (at p<0.05) exceeding the mean group value and/or the presence of chromosome type exchange aberrations, were found in 45 women (group B). Statistical hypotheses on the possible correlations between the cytogenetic anomalies, BBD, level of the territory radiation contamination, and the absorbed thyroid dose were tested. The proportion of women with BBD was approximately the same in groups A and B (68 and 64%, respectively; p=0.665), which did not allow us to state that abnormal chromosome patterns can be used as diagnosis markers. The data obtained showed some positive trends between the cytogenetic anomalies, breast disorders, level of the territory contamination and the thyroid dose. In addition, it is interesting to note that the inclusion of the body mass index (BMI) into the data analysis showed that, both in women with cytogenetic anomalies (group B) and among the women with BBD, this index was essentially lower than in the respective comparison groups. The BMI differences could not be explained by the age differences, since the latter were insignificant in all the cases (p>0.8).

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“…The use of 1-2 types of reparation-detective cells can lead to erroneous conclusions on the necessity of DNA repair functioning for the formation of AR. AR was not observed in atactic [12], Down's syndrome [5], or xeroderma pigmentosum [2] cells. Thus, we found a cell system for identification of NG-induced DNA damage.…”

Section: Resultsmentioning

confidence: 99%

“…Studies of AR in atactic cells showed contradictory results. In cells from patients with hyperradiosensitivity AR was observed after preliminary low-dose X-ray exposure followed by high-dose irradiation [13], while other scientists detect no AR in patients with ataxia and Down's syndrome [5,12]. We studied AR in reparation-defective gout cells characterized by defective repair of DNA [4].…”

mentioning

confidence: 99%

Adaptive response in the reparation-defective gout cells

1999

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Adaptive response of fibroblasts from skin biopsy specimens from patients with gout has been studied; these cells are characterized as reparation-detective during exposure to mutagens Nmethyl-N'-nitro-N-nitrosoguanidine and 4-nitroquinolin-N-oxide. Adaptive response formed during exposure to nitrosoguanidine. The data indicate that the formation of adaptive response does not depend on DNA reparation.

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Absence of a radiation-induced adaptive response of lymphocytes in Down's syndrome

Cited by 5 publications

References 8 publications

Mechanisms of human cell protection associated with genetic polymorphism

Mechanisms of human cell protection associated with genetic polymorphism

Analysis of Chromosome Lesions in Women with Benign Breast Diseases, Residing in the Territories Contaminated as a Result of the Chernobyl Accident

Adaptive response in the reparation-defective gout cells

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