Absence of candidemia in critically ill patients with COVID-19 receiving selective digestive decontamination

Buil, Jochem B.; Schouten, Jeroen; Wauters, Joost; Hoeven, Hans van de; Verweij, Paul E.

doi:10.1007/s00134-022-06651-y

Cited by 8 publications

(5 citation statements)

References 7 publications

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“…Not surprisingly, their mortality rate was higher not only than that in non-VAP patients, but also than that reported in other studies involving similar patients. The baseline conditions were similar between VAP and non-VAP patients, apart from a more frequent smoking habit and diabetes in non-VAP patients, despite them being known as possible risk factors for VAP [49].…”

Section: Discussionmentioning

confidence: 85%

Effects of the Selective Decontamination of the Digestive Tract (SDD) on Pulmonary Secondary Infections in Patients with COVID-19 Acute Respiratory Distress Syndrome: A Retrospective Single Centre Experience

Berlot,

Moro,

Zio

et al. 2023

Gastrointestinal Disorders

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Definitive data on the incidence rate of ventilator-associated pneumonia (VAP) in COVID-19 are still lacking, ranging from 29 to 58%. To date, most of the existing literature refers to patients who are not subjected to VAP prevention with selective decontamination of the digestive tract (SDD). We retrospectively collected data on all COVID-19 patients admitted to our ICU during the second phase of the pandemic with the aim of assessing the occurrence of VAP and the related mortality at 30 days and comparing our findings with the available literature. Of 213 patients, only 74 were eligible for the analysis. An incidence of 6.90 VAP per 1000 days of mechanical ventilation was detected. Apart from a smoking habit (0% vs. 10%, p < 0.005) and diabetes (14% vs. 54%, p = 0.026), patients who developed VAP did not differ significantly from those who did not regarding comorbidities, steroid use, and the severity of COVID-19. VAP were predominantly caused by mono-microbial Gram-negative or fungal infections. Mortality was significantly higher in those who developed VAP (86 vs. 33%, p = 0.002). Our evidence aligned with the available literature in assuming a possible role of SDD in reducing the incidence of VAP in COVID-19 patients, with a possible impact on related mortality and costs.

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Section: Discussionmentioning

confidence: 85%

Effects of the Selective Decontamination of the Digestive Tract (SDD) on Pulmonary Secondary Infections in Patients with COVID-19 Acute Respiratory Distress Syndrome: A Retrospective Single Centre Experience

Berlot,

Moro,

Zio

et al. 2023

Gastrointestinal Disorders

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“…The main risk factors in invasive candidiasis involving gastrointestinal Candida spp. colonization are impaired intestinal epithelial permeability and immunosuppression ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

“…The mortality of candidemia associated with COVID19 disease has been reported to be between 40–70%. However, mortality caused by candidemia is unknown ( 14 ). In our study, mortality in patients with COVID 19 disease was found to be similar (66%), and there was no significant difference in mortality between both candidemia patient group (p=0.652).…”

Section: Discussionmentioning

confidence: 99%

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Risk analysis of candidemia and its effect on mortality in COVID 19 and non COVID 19 patients

Özmerdiven,

İrvem,

Şahin

2024

IJM

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Background and Objectives: Candidemia is the most common serious fungal infection in critically ill patients in intensive care units (ICU). It series fourth among bloodstream infectious agents. In this study, candidemia risk analysis was examined in COVID 19 and non-COVID 19 patients during the pandemic period. Materials and Methods: COVID 19 and non-COVID 19 cases who were followed up with candidemia in the ICU of our hospital were retrospectively screened. Demographic data, intubation, central venous catheter (CVC), medications, and to- tal parenteral nutrition (TPN) status were evaluated in terms of risk between the two groups. Isolated Candida species and susceptibilty were evaluated. Results: When age, gender, medication, intubation, TPN and CVC were evaluated, no difference was seen in terms of risk. Differences were detected in terms of comorbidities. While the most frequently identified Candida species was C. albicans, the most frequently detected species in the COVID19 patient group was C. parapsilosis. Conclusion: There was no difference in candidemia incidence and risk factors between the two groups. Since candidemias were evaluated in terms of comorbidities, it was determined that Diabetes Mellitus (DM) and chronic obstructive pulmoner disease (COPD) were more common in patients with COVID 19 and less common in coronary artery disease (CAD) and malignancy.

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“…( 92 ). Overall, mortality rates have varied between studies and have been reported to be between 40% and 70%, though differences in mortality rates between COVID-19 and non-COVID-19 patients were not found to be statistically significant ( 93 ). Moreover, it was shown that candidemia in COVID-19 patients was not attributed to increased mortality.…”

Section: Fungal Co-infections In Covid-19 Patientsmentioning

confidence: 99%

COVID-19 and Fungal infections: a double debacle

Mina

Yaakoub

Annweiler

et al. 2022

Microbes and Infection

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Absence of candidemia in critically ill patients with COVID-19 receiving selective digestive decontamination

Cited by 8 publications

References 7 publications

Effects of the Selective Decontamination of the Digestive Tract (SDD) on Pulmonary Secondary Infections in Patients with COVID-19 Acute Respiratory Distress Syndrome: A Retrospective Single Centre Experience

Effects of the Selective Decontamination of the Digestive Tract (SDD) on Pulmonary Secondary Infections in Patients with COVID-19 Acute Respiratory Distress Syndrome: A Retrospective Single Centre Experience

Risk analysis of candidemia and its effect on mortality in COVID 19 and non COVID 19 patients

COVID-19 and Fungal infections: a double debacle

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