Absence of Cilia and Basal Bodies with Predominance of Brush Cells in the Respiratory Mucosa from a Patient with Immotile Cilia Syndrome (UP 6:45‐59, 1984)

Cerezo, Lizardo; Price, George F.

doi:10.3109/01913128509141528

Cited by 9 publications

(6 citation statements)

References 2 publications

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“…1990) respiratory tract; in conditions such as desquamative interstitial pneumonitis (DiMaio et al. 1988) and immotile cilia syndrome (Gordon & Kattan, 1984; Cerezo & Price, 1985), but not in healthy alveolar lining, and in gastric mucosa (Johnson & Young, 1968) and gallbladder (Gilloteaux et al. 1989).…”

Section: Introductionmentioning

confidence: 99%

Brush cells in the human duodenojejunal junction: an ultrastructural study

2007

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Brush cells have been identified in the respiratory and gastrointestinal tract mucosa of many mammalian species. In humans they are found in the respiratory tract and the gastrointestinal apparatus, in both the stomach and the gallbladder. The function of brush cells is unknown, and most morphological data have been obtained in rodents. To extend our knowledge of human brush cells, we performed an ultrastructural investigation of human small intestine brush cells. Six brush cells identified in five out of more than 300 small intestine biopsies performed for gastrointestinal tract disorders were examined by transmission electron microscopy. Five brush cells were located on the surface epithelium and one in a crypt. The five surface brush cells were characterized by a narrow apical pole from which emerged microvilli that were longer and thicker than those of enterocytes. The filamentous core extended far into the cell body without forming the terminal web. Caveolae were abundant. Filaments were in the form of microfilaments and intermediate filaments. Cytoplasmic projections containing filaments were found on the basolateral surface of brush cells. In a single cell, axons containing vesicles and dense core granules were in close contact both with the basal and the lateral surface of the cell. The crypt brush cell appeared less mature. We concluded that human small intestine brush cells share a similar ultrastructural biology with those of other mammals. They are polarized and well-differentiated cells endowed with a distinctive cytoskeleton. The observation of nerve fibres closely associated with brush cells, never previously described in humans, lends support to the hypothesis of a receptor role for these cells.

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Section: Introductionmentioning

confidence: 99%

Brush cells in the human duodenojejunal junction: an ultrastructural study

2007

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“…Of the 11 specific PCD groups defined by Afzelius et al 2001 one is acilia syndrome (AS). AS is an infrequent form of PCD characterised by total absence of cilia [Dudley et al, 1982; Fonzi et al, 1982; Götz and Stockinger, 1983; Gordon and Kattan, 1984; Welch et al, 1984; Babin and Kavanagh, 1985; Cerezo and Price, 1985; de Santi et al, 1988; Phillips, 1989; Richard et al, 1989; Soferman et al, 1996; Maiti et al, 2000]. AS probably is a separate entity in PCD and the disease gene has not yet been identified [Maiti et al, 2000].…”

Section: To the Editormentioning

confidence: 99%

Candidate gene analysis in three families with acilia syndrome

Wessels

Avital

Failly

et al. 2008

American J of Med Genetics Pt A

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“…No formal quantitation was applied in these studies. Increased numbers of brush cells have also been described in a human infant with desquamative interstitial pneumonitis (3) and in immotile cilia syndrome (4,5). No systematic studies of brush cells and their distribution in human lung are available.…”

Section: Distribution Of Lung Brush Cellsmentioning

confidence: 99%

“…The function(s) of brush cells is uncertain. Pathologically, increased numbers of airway brush cells have been described in a human infant with desquamative interstitial pneumonitis (3) and in the immotile cilia syndrome (4,5), but whether this is a true event or whether the increased number reflects an abnormality of lung development is not certain.…”

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confidence: 99%