Absence of effects of lead feedings and growth-retardation on mitochondrial and microsomal cytochromes in the developing brain

Holtzman, David; Hsu, J Shen; Desautel, Marcia

doi:10.1016/0041-008x(81)90114-9

Cited by 11 publications

(1 citation statement)

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“…AChE activity is dependent on the availability of the acetylcholine (ACh), which is synthesized by the process of acetyl-Co-A and choline. Acetyl-Co-A is synthesized from pyruvate, which is an energy dependent process [18]. Studies showed that Al exposure significantly reduces hexokinase activity, which in turn may decrease pyruvate formation, thereby reducing acetylcholine formation.…”

Section: Discussionmentioning

confidence: 99%

Biochemical alterations in rat brain following aluminum exposure: Protection with centrophenoxine

Nehru

Bhalla

2007

Toxicological & Environmental Chemistry

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Aluminum (Al) is a neurotoxicant potentially affecting ionic, cholinergic, and dopaminergic neurotransmission in the central nervous system. These alterations are known to be associated with learning ability, adaptive responses, and other aspects of behavior. The present experiment was designed to study the neurotoxic consequences of Al exposure on neurotransmitters like dopamine (DA), serotonin (5-HT), norepinephrine (NE) along with the activity of acetylcholinesterase (AChE). Furthermore, Centrophenoxine (CpH) was administered as a post treatment to evaluate its potential in Al-induced neurotoxicity. The cognitive functions and memory loss were also studied after both Al and CpH administration. Al was administered orally at a dose of 40 mg kg À1 day À1 for a period of 8 weeks, whereas CpH was administered intraperitoneally at a dose of 100 À1 mg kg À1 day À1 for a period of 6 weeks. The study was carried out in four regions of the brain, namely cerebrum, cerebellum, medulla oblongata, and hypothalamus. A significant reduction in AChE activity and different neurotransmitters was observed after Al exposure in the regions. CpH as a post treatment proved beneficial in restoring these alterations. Al exposure also affected the cognitive functions and short-term memory, which were significantly improved following CpH post treatment.

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Section: Discussionmentioning

confidence: 99%