Absence of exercise-induced variations in adiponectin levels despite decreased abdominal adiposity and improved insulin sensitivity in type 2 diabetic men

Boudou, Philippe; Sobngwi, Eugène; Mauvais-Jarvis, Franck; Vexiau, P.; Jf, Gautier

doi:10.1530/eje.0.1490421

Cited by 162 publications

(168 citation statements)

References 20 publications

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“…Twelve weeks of endurance and circuit weight training did not change serum adiponectin concentrations, in accordance with the general consensus (3,(8)(9)(10)(11). There are only few endurance-training studies that have reported different findings (12-15).…”

Section: Discussionsupporting

confidence: 85%

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Effects of resistance versus endurance training on serum adiponectin and insulin resistance index

Ahmadizad

Haghighi²,

Hamedinia³

2007

European Journal of Endocrinology

104

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Purpose: The purpose of the present study was to investigate the effects of resistance and endurance training on serum adiponectin and insulin resistance index (S I ) in healthy men. Methods: Twenty-four healthy males (age, 35-48 years) participated in the study. The subjects were randomly assigned to one of three groups: endurance training group (nZ8), resistance training group (nZ8) and control group (nZ8). Blood samples were taken in fasting state from all subjects. The experimental groups performed either endurance or resistance training 3 days a week for 12 weeks. The endurance training programme included continuous running at an intensity corresponding to 75-85% of maximal heart rate, while resistance training consisted of four sets of circuit weight training for 11 stations and at an intensity corresponding to 50-60% of one-repetition maximum. The maximum numbers of repetitions in each station was 12.Results: There were significant negative correlations between serum adiponectin and body fat percentage, waist-to-hip ratio, body mass index and the insulin resistance index at baseline, whereas changes in response to training were not significantly correlated. Both endurance and resistance training resulted in a significant decrease in the S I in comparison with the control group. However, serum adiponectin did not change significantly in response to resistance and endurance training. Conclusion: Endurance and resistance training caused an improvement in insulin resistance in healthy men, but this improvement was not accompanied by increased adiponectin levels.European Journal of Endocrinology 157 625-631

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Section: Discussionsupporting

confidence: 85%

“…However, there is still controversy with regard to the effects of endurance training on adiponectin. For example, different authors have demonstrated no change (3,(8)(9)(10)(11), an increase (12)(13)(14) or a decrease (15) in adiponectin following different training protocols.…”

Section: Introductionmentioning

confidence: 99%

Effects of resistance versus endurance training on serum adiponectin and insulin resistance index

Ahmadizad

Haghighi²,

Hamedinia³

2007

European Journal of Endocrinology

104

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“…23,24 In these studies, the training period of 8 weeks was 33% shorter, but the relative exercise intensity and mode of exercise training (i.e., cycle ergometer) were relatively has not been well tested, and future studies are needed to identify potential changes in the expression of proinfl ammatory cytokines in abdominal adipose tissue and their relationship to changes in hepatic and peripheral insulin sensitivity.…”

Section: Peak Oxygen Consumption and Maximum Work Outputmentioning

confidence: 99%

Influence of Exercise Intensity on Abdominal Fat and Adiponectin in Elderly Adults

Coker

Williams

Kortebein

et al. 2009

Metabolic Syndrome and Related Disorders

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To examine the infl uence of moderate-intensity (50% of VO 2peak ) exercise training (MI) versus high-intensity (75% of VO 2peak ) exercise training (HI) on regional fat distribution and plasma adiponectin, we randomized 18 overweight (body mass index [BMI] = 30 ± 1 kg/m 2 ) elderly (71 ± 1 years) to HI, MI, or a control group (CON). Subjects enrolled in HI or MI completed a 12-week exercise training protocol designed to expend 1000 kcal/ week. Body composition testing was completed prior to and following the exercise training using dual energy X-ray absorptiometry and a computed tomography scan. Plasma adiponectin was measured using enzymelinked immunoassay (ELISA). VO 2peak improved in HI and MI, whereas there was no change in VO 2peak in CON. No signifi cant change in body weight, BMI, and % fat occurred in MI, HI, or CON. Although there was a significant reduction in visceral fat with HI (−39 cm 2 ), there was no change in the MI or CON groups. In addition, there was a signifi cant increase in thigh muscle attenuation in the HI group. There were no changes in thigh muscle attenuation in the MI and CON groups. Also, there was no change in plasma adiponectin in the MI, HI, or CON groups. In summary, our direct comparison of exercise intensity without weight loss promotes the effi cacy of HI in the reduction in visceral fat, even without changes in adiponectin.

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“…Kraemer et al (15) investigated the acute effects of short-term, running exercise on plasma adiponectin secretion in healthy subjects but observed no changes. Other studies, exploring the more long-term benefits of exercise training, also reported no changes in basal plasma adiponectin concentration (16)(17)(18)22). In contrast, Kriketos et al (19) recently reported substantially elevated fasting plasma adiponectin levels (260% above baseline values) after 2-3 bouts of low to moderate intensity exercise.…”

Section: Introductionmentioning

confidence: 99%

The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle

et al. 2005

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Objective: It has been suggested that adiponectin regulates plasma free fatty acid (FFA) clearance by stimulating FFA uptake and/or oxidation in muscle. We aimed to determine changes in plasma adiponectin concentration and adiponectin receptor 1 and 2 mRNA expression in skeletal muscle during and after prolonged exercise under normal, fasting conditions (high FFA trial; HFA) and following pharmacological inhibition of adipose tissue lipolysis (low FFA trial; LFA). Furthermore, we aimed to detect and locate adiponectin in skeletal muscle tissue. Methods: Ten subjects performed two exercise trials (120 min at 50% VO 2max ). Indirect calorimetry was used to determine total fat oxidation rate. Plasma samples were collected at rest, during exercise and during post-exercise recovery to determine adiponectin, FFA and glycerol concentrations. Muscle biopsies were taken to determine adiponectin protein and adiponectin receptor 1 and 2 mRNA expression and to localise intramyocellular adiponectin. Results: Basal plasma adiponectin concentrations averaged 6.57^0.7 and 6.63^0.8 mg/l in the HFA and LFA trials respectively, and did not change significantly during or after exercise. In the LFA trial, plasma FFA concentrations and total fat oxidation rates were substantially reduced. However, plasma adiponectin and muscle adiponectin receptor 1 and 2 mRNA expression did not differ between trials. Immunohistochemical staining of muscle cross-sections showed the presence of adiponectin in the sarcolemma of individual muscle fibres and within the interfibrillar arterioles.

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Absence of exercise-induced variations in adiponectin levels despite decreased abdominal adiposity and improved insulin sensitivity in type 2 diabetic men

Cited by 162 publications

References 20 publications

Effects of resistance versus endurance training on serum adiponectin and insulin resistance index

Effects of resistance versus endurance training on serum adiponectin and insulin resistance index

Influence of Exercise Intensity on Abdominal Fat and Adiponectin in Elderly Adults

The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle

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