Absence of GSTT1 and polymorphisms in GSTP1 and TP53 are associated with the incidence of acne vulgaris

Ullah, Rehmat; Afgan, Sher; Akhtar, Mariyam; Asif, Muhammad; Latif, Muhammad; Mehmood, Rashid; Naeem, Muhammad; Zahra, Kiran; Farooq, Muhammad; Saïd, Mourad Ben

doi:10.1111/srt.13333

Cited by 2 publications

(2 citation statements)

References 30 publications

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“… 10 The genotypes of glutathione S‐transferases (GSTs) and TP53 play a role in protecting against oxidative stress and may influence AV progression. 11 Also, patients diagnosed with TCAC and CAGG had a higher prevalence than healthy patients with TAAC and CCAC. The linkage disequilibrium between rs433235 A > G and IVS5.59 C > A has been identified.…”

Section: Discussionmentioning

confidence: 99%

“…Cutibacterium acnes colonization, inflammation, and estrogen‐dependent sebogenesis are the four main components implicated in the pathophysiology of acne 10 . The genotypes of glutathione S‐transferases (GSTs) and TP53 play a role in protecting against oxidative stress and may influence AV progression 11 . Also, patients diagnosed with TCAC and CAGG had a higher prevalence than healthy patients with TAAC and CCAC.…”

Section: Discussionmentioning

confidence: 99%

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In severe acne vulgaris, TNF‐α gene variants are connected to increased TNF‐α gene expression and insulin resistance

AbdElneam,

Alhajlah,

Al‐Dhubaibi

et al. 2024

Skin Research and Technology

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BackgroundAcne vulgaris (AV) is a chronic inflammatory skin condition affecting the pilosebaceous unit, commonly presenting as comedones, papules, pustules, or nodules on the face, upper limbs, torso, and back, with comedones formation being the primary pathology leading to disfiguring inflammation, hyperpigmentation, scarring, and psychological impact.AimThe purpose of this study was to investigate the significance of two genetic variants in the promoter region of the tumor necrosis factor‐alpha (TNF‐α) gene and their association with insulin resistance (IR) in acne patients. To understand how these variants contribute to AV and its associated IR.Subjects and methodsAn analytical cross‐sectional study with a case‐control design and research evaluation was carried out on 87 AV patients and 73 healthy volunteers. The medical histories of both groups were obtained, as well as the severity and duration of inflammation among acne sufferers, as well as demographic data. Biochemical analysis was performed on both sets of participants, including fasting blood glucose levels, insulin levels while fasting, IR, and serum TNF‐α. PCR‐RFLP analysis identified −863 G > A (rs1800630) and −308 G > A (rs1800629) variations, and real‐time PCR analysis evaluated TNF‐α gene expression in both patients and healthy people.ResultsAcne patients exhibited significantly higher levels of IR, fasting glucose, fasting insulin, serum TNF‐α, and TNF‐α folding change, when compared to healthy controls. The co‐dominant model for −863 G > A and −308 G > A variants exhibited significant variations between the two groups. Severe acne patients who had the A/A genotype for −308 variants exhibited higher levels of IR, serum TNF‐α, and TNF‐α folding change. Highly significant positive linear correlation between IR, serum TNF‐α, and TNF‐α folding change in severe AV.ConclusionThere is a correlation between AV, especially severe acne, and the −863 G > A and −308 G > A polymorphism, which influences TNF‐α gene expression and serum TNF‐α levels.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

In severe acne vulgaris, TNF‐α gene variants are connected to increased TNF‐α gene expression and insulin resistance

AbdElneam,

Alhajlah,

Al‐Dhubaibi

et al. 2024

Skin Research and Technology

View full text Add to dashboard Cite

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Absence of GSTT1 and polymorphisms in GSTP1 and TP53 are associated with the incidence of acne vulgaris

Ullah

Afgan

Akhtar

et al. 2023

Skin Research and Technology

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Backgrounds Acne vulgaris is a chronic inflammatory skin disease of the pilosebaceous unit affecting most teenagers and numerous adults throughout the world. The present study was designed to assess the association of the presence or absence of GSTM1, GSTT1, and single nucleotide polymorphisms rs1695 in GSTP1 and rs1042522 in TP53 gene with acne vulgaris. Methods The cross‐sectional case–control study was conducted at the Institute of Zoology from May 2020 to March 2021 and included acne vulgaris patients (N = 100) and controls (N = 100) enrolled in Dera Ghazi Khan district, Pakistan. Multiplex and tetra‐primer amplification refractory mutation system‐polymerase chain reactions were applied to investigate the genotype in analyzed genes. The association of rs1695 and rs1042522 with acne vulgaris was studied either individually or in various combinations with GATM1 and T1. Results A significant association of absence of GSTT1 and mutant genotype at rs1695 (GG) and at rs1042522 (CC) in GSTP1 and TP53, respectively, was found to be associated with acne vulgaris in enrolled subjects. Subjects aged 10–25 years and smokers were more susceptible to acne vulgaris. Conclusion Our results suggest that genotypes of glutathione S‐transferases (GSTs) and TP53 are involved in protection against oxidative stress and may influence disease progression in acne vulgaris.

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Absence of GSTT1 and polymorphisms in GSTP1 and TP53 are associated with the incidence of acne vulgaris

Cited by 2 publications

References 30 publications

In severe acne vulgaris, TNF‐α gene variants are connected to increased TNF‐α gene expression and insulin resistance

In severe acne vulgaris, TNF‐α gene variants are connected to increased TNF‐α gene expression and insulin resistance

Absence of GSTT1 and polymorphisms in GSTP1 and TP53 are associated with the incidence of acne vulgaris

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