2010
DOI: 10.1016/j.fertnstert.2009.09.049
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Absence of insulin resistance and low-grade inflammation despite early metabolic syndrome manifestations in children born after in vitro fertilization

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Cited by 129 publications
(135 citation statements)
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“…There are concerns regarding the potential consequences of ART on the long-term health of the offspring, but there is little information. 3,5,6 Here, we show that healthy children and adolescents conceived by ART display marked vascular dysfunction of the systemic and pulmonary circulation. This problem does not appear to be related to parental factors or hormonal stimulation of ovulation in the mother but to the ART procedure itself.…”
Section: Discussionmentioning
confidence: 60%
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“…There are concerns regarding the potential consequences of ART on the long-term health of the offspring, but there is little information. 3,5,6 Here, we show that healthy children and adolescents conceived by ART display marked vascular dysfunction of the systemic and pulmonary circulation. This problem does not appear to be related to parental factors or hormonal stimulation of ovulation in the mother but to the ART procedure itself.…”
Section: Discussionmentioning
confidence: 60%
“…2 Therefore, the safety of ART for long-term health is of utmost importance, but there is little information. [3][4][5][6] This may be related, at least in part, to the young age of the progeny because clinically manifest disease may not yet have had time to develop.…”
mentioning
confidence: 99%
“…The price of multiple assessments is a substantially higher attrition rate. Therefore, studies evaluating the effects of reproductive technologies all opted to measure BP on a single day (7,9,30). For the follow-up at older ages, a 24-h telemetric approach could be a good alternative.…”
Section: Strengths and Weaknessesmentioning
confidence: 99%
“…IVF and ICSI are also suggested to change the early environment in such a manner that it may have long-term consequences for the offspring (21). Indeed, several studies suggested subtle cardiometabolic alterations in IVF/ICSI offspring (5,6,8,9). This was partly expected, as IVF and ICSI conceptions more often result in preterm birth and low birth weight, which are risk factors for adiposity and hypertension (22).…”
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confidence: 99%
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