Absence of Relevant Thermal Conversion of Cannabidiol (CBD) to Tetrahydrocannabinol (THC) in E-Cigarette Vapor and Low-THC Cannabis Smoke

Abstract

Introduction: Recent research claimed that cannabidiol (CBD) in commercial electronic cigarette (e-cigarette) liquids can be converted into psychotropic amounts of ∆9-tetrahydrocannabinol (THC). This study aims to validate this claim by a realistic e-cigarette setup. Additionally, this study also investigates if such a conversion may occur during smoking of CBD-rich cannabis joints. Methods: Two different CBD-liquids were vaporized using two different e-cigarette models, one of which was operated at extreme energy settings (0.2 Ω and 200 W). The smoke of six CBD joints was collected using a rotary smoking machine according to ISO 4387:2019. Analyses were conducted using nuclear magnetic resonance (NMR) spectrometry as well as liquid chromatography tandem mass spectrometry (LC-MS/MS). Results: For the condensed e-cigarette liquids, no increase in THC concentration could be observed. For the CBD joints, no formation of THC was provable. The recovered THC concentrations were ranging between 1% and 48% of the THC amount initially contained in the joints before smoking. Conclusions: Using realistic conditions of consumer exposure, relevant conversion of CBD to THC appears not to be occurring. The health risk of CBD liquids for electronic cigarettes as well as low-THC cannabis intended for smoking can be assessed by the concentrations in the source material without need to consider significant changes in psychotropic compounds during use by consumers.

Stability of Δ⁹-tetrahydrocannabinol acetate in e-liquid in the presence of diluents or during vaping

“…するため，グリセリン [5][6][7][8][9] ，プロピレングリコール (PG) [5][6][7][8][9][10] ，ポリエチレングリコール(PEG) 5,10) ，ビ タミン E アセテート(VEA) 8,[10][11][12] および中鎖脂肪酸 トリグリセリド(medium chain triglyceride, MCT) 8,[10][11][12] device, which was heated and vaporized using a syringe connected to the cartridge through a silicone tube. The Δ 9 -THC-OAc liquid was put into a test tube and heated at 200 or 400°C for 5 min.…”