Absence of Sry in species of the vole Ellobius

Just, Walter; Rau, W.; Vogel, Walther; Akhverdian, Mikhail; Fredga, Karl; Graves, Jennifer A. Marshall; Lyapunova, E. A.

doi:10.1038/ng1095-117

Cited by 203 publications

(128 citation statements)

References 11 publications

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“…Independently, loss of the Y and SRY has occurred in two species of the mole vole Ellobius 75, which presumably now determine sex by an as yet undiscovered gene on the X or autosomes. The loss of the SRY sex determining mechanism seems to have been accompanied by changes in its target gene SOX9 that may have led to its upregulation in the absence of SRY 76.…”

Section: How Do New Sex Chromosomes Become Fixed?mentioning

confidence: 99%

Did sex chromosome turnover promote divergence of the major mammal groups?

Graves

2016

BioEssays

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Comparative mapping and sequencing show that turnover of sex determining genes and chromosomes, and sex chromosome rearrangements, accompany speciation in many vertebrates. Here I review the evidence and propose that the evolution of therian mammals was precipitated by evolution of the male‐determining SRY gene, defining a novel XY sex chromosome pair, and interposing a reproductive barrier with the ancestral population of synapsid reptiles 190 million years ago (MYA). Divergence was reinforced by multiple translocations in monotreme sex chromosomes, the first of which supplied a novel sex determining gene. A sex chromosome‐autosome fusion may have separated eutherians (placental mammals) from marsupials 160 MYA. Another burst of sex chromosome change and speciation is occurring in rodents, precipitated by the degradation of the Y. And although primates have a more stable Y chromosome, it may be just a matter of time before the same fate overtakes our own lineage.Also watch the video abstract.

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Section: How Do New Sex Chromosomes Become Fixed?mentioning

confidence: 99%

Did sex chromosome turnover promote divergence of the major mammal groups?

Graves

2016

BioEssays

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“…This newly formed sex chromosome then undergoes specialization and degeneration mechanisms (Graves, 2006). In terms of the degenerative mechanism, it is not surprising to find mammals without SRY as a testis determinant, as is the case in some rodents, which are the most rapidly evolving species (Just et al, 1995, Soullier et al, 1998Sutou et al, 2001, Veyrunes et al, 2010. In line with this idea, mice could be considered as the most evolved mammalian species in terms of Sry function; this species is in the closest position from the end-point of Sry action, corresponding to loss of the Y chromosome.…”

Section: What Might Explain Differences In Sry/sry Expression Betweenmentioning

confidence: 99%

A study of goat SRY protein expression suggests putative new roles for this gene in the developing testis of a species with long‐lasting SRY expression

Montazer-Torbati

Kocer

Auguste

et al. 2010

Developmental Dynamics

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The testis-determining gene SRY is not well-conserved among mammals, and particularly between mouse and other mammals. To evaluate SRY function in a nonrodent species, we produced an antibody against goat SRY and used it to investigate the expression pattern of SRY throughout goat testicular development. By contrast with the mouse, SRY is primarily expressed in most cells of XY genital-ridges and not solely in pre-Sertoli cells. Between cord formation and prepuberty, SRY remains expressed in both Sertoli and germinal cells. During adulthood, SRY expression declines and then disappears from meiotic germ cells, only remaining present at low levels in some spermatogonia. Unlike the germinal lineage, SRY continues to be highly expressed in adult Sertoli cells with a typical nuclear staining. Our data indicate that in goat, the role of SRY may not be limited to testis determination and could have other functions in testicular maintenance and hence male fertility. Developmental Dynamics 239:3324-3335,

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“…(3) This is not to be confused with sex determination, the focus of this essay, which is the process that directs differentiation to proceed down one or the other pathway, male or female. Mammals show a genetic or chromosomal form of sex determination, referred to as genotypic sex determination or GSD, with all but mole voles and a spiny rat (4,5) having an XY male/XX female system. Birds too have a stable chromosomal sex-determining system-all taxa have female heterogamety.…”

Section: Introductionmentioning

confidence: 99%

The ends of a continuum: genetic and temperature‐dependent sex determination in reptiles

Sarre¹,

Georges²,

Quinn³

2004

BioEssays

278

259

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Two prevailing paradigms explain the diversity of sex‐determining modes in reptiles. Many researchers, particularly those who study reptiles, consider genetic and environmental sex‐determining mechanisms to be fundamentally different, and that one can be demonstrated experimentally to the exclusion of the other. Other researchers, principally those who take a broader taxonomic perspective, argue that no clear boundaries exist between them. Indeed, we argue that genetic and environmental sex determination in reptiles should be seen as a continuum of states represented by species whose sex is determined primarily by genotype, species where genetic and environmental mechanisms coexist and interact in lesser or greater measure to bring about sex phenotypes, and species where sex is determined primarily by environment. To do otherwise limits the scope of investigations into the transition between the two and reduces opportunities to use studies of reptiles to advance understanding of vertebrate sex determination generally. BioEssays 26:639–645, 2004. © 2004 Wiley Periodicals, Inc.

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Absence of Sry in species of the vole Ellobius

Cited by 203 publications

References 11 publications

Did sex chromosome turnover promote divergence of the major mammal groups?

Did sex chromosome turnover promote divergence of the major mammal groups?

A study of goat SRY protein expression suggests putative new roles for this gene in the developing testis of a species with long‐lasting SRY expression

The ends of a continuum: genetic and temperature‐dependent sex determination in reptiles

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