Absolute configurations of talaromycones A and B, α-diversonolic ester, and aspergillusone B from endophytic Talaromyces sp. ECN211

Abstract

Talaromycones A (1) and B (2), new xanthenediones, were isolated from the cultures of Talaromyces sp. ECN211, an endophytic fungus, along with α-diversonolic ester (3), aspergillusone B (4), glauconic acid (5), and rosellisin (6). The planar structures of 1 and 2 were elucidated by extensive spectroscopic analyses. Furthermore, the absolute configurations of 1-4 were determined by single-crystal X-ray diffraction and electronic circular dichroism spectroscopy (ECD). In addition, the crystallographic data for 5 were updated for the first time in over 50 years. 290

Cytotoxic Xanthone Derivatives from the Mangrove-Derived Endophytic Fungus Peniophora incarnata Z4

“…Xanthones, widely found in bacteria, fungi, and plants, − are typically polysubstituted and further classed as either fully aromatic, dihydro, tetrahydro, or hexahydro derivatives based upon the level of oxidation of the C-ring . The di- or tetra-hydroxanthones occur as monomers, for example, talaromycones A and B, globosuxanthones A and B, 3,4-dihydroglobosuxanthone A, α- and β-diversonolic esters, and monodictysins A–C. ,− Xanthone dimers and heterodimers possess complex structures, the majority of which have been identified as 2,2′-( ortho – ortho )-linked, such as vinaxanthones, ascherxanthones A and B, and ergochromes, except for chrysoxanthone, which has an ether linkage. − Members of the xanthone family showed a broad spectrum of activities, such as cytotoxicity, antibacterial, and neuroprotective activities. − During our search for new bioactive secondary metabolites of fungi isolated from various habitats, − a mangrove endophytic fungus Z4 was obtained and identified as Peniophora incarnata , which was isolated from Bruguiera gymnorrhiza in the South China Sea. Given that mangroves grow in a complex ecological system, it is reasonable to believe that the mangrove-derived fungi may produce secondary metabolites with novel structures or possessing significant pharmacological activity.…”