Absolute versus relative measures of plasma fatty acids and health outcomes: example of phospholipid omega-3 and omega-6 fatty acids and all-cause mortality in women

Miura, Kyoko; Hughes, Maria Celia; Ungerer, Jacobus; Smith, David; Green, Adèle C.

doi:10.1007/s00394-016-1358-y

Cited by 18 publications

(15 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We can measure omega-3 FAs concentration in plasma, serum, blood cells and lymph. The content of FAs in the plasma reflects the short to medium-long supply of fatty acids in the diet, while the concentration of fatty acids in the blood cells is usually a good indicator of long-term bioavailability [ 167 , 175 ]. As far as the long-chain omega-3 fatty acids are concerned, it is possible to measure many markers that indicate the presence of DHA in a specific form, but only one (the level of phospholipid EPA in plasma) that is useful for determining the level of EPA [ 167 , 176 ].…”

Section: Bioavailabilitymentioning

confidence: 99%

A Comprehensive Review of Chemistry, Sources and Bioavailability of Omega-3 Fatty Acids

2018

View full text Add to dashboard Cite

Omega-3 fatty acids, one of the key building blocks of cell membranes, have been of particular interest to scientists for many years. However, only a small group of the most important omega-3 polyunsaturated fatty acids are considered. This full-length review presents a broad and relatively complete cross-section of knowledge about omega-3 monounsaturated fatty acids, polyunsaturates, and an outline of their modifications. This is important because all these subgroups undoubtedly play an important role in the function of organisms. Some monounsaturated omega-3s are pheromone precursors in insects. Polyunsaturates with a very long chain are commonly found in the central nervous system and mammalian testes, in sponge organisms, and are also immunomodulating agents. Numerous modifications of omega-3 acids are plant hormones. Their chemical structure, chemical binding (in triacylglycerols, phospholipids, and ethyl esters) and bioavailability have been widely discussed indicating a correlation between the last two. Particular attention is paid to the effective methods of supplementation, and a detailed list of sources of omega-3 acids is presented, with meticulous reference to the generally available food. Both the oral and parenteral routes of administration are taken into account, and the omega-3 transport through the blood-brain barrier is mentioned. Having different eating habits in mind, the interactions between food fatty acids intake are discussed. Omega-3 acids are very susceptible to oxidation, and storage conditions often lead to a dramatic increase in this exposure. Therefore, the effect of oxidation on their bioavailability is briefly outlined.

show abstract

Section: Bioavailabilitymentioning

confidence: 99%

A Comprehensive Review of Chemistry, Sources and Bioavailability of Omega-3 Fatty Acids

2018

View full text Add to dashboard Cite

show abstract

“…Fortunately, blood plasma, serum, blood cells, and lymph can be measured for Ω3FA concentrations, where blood cell fatty acid concentrations indicate long-term bioavailability. In contrast, blood plasma fatty acid concentrations reflect the short- to medium-term supply of fatty acids in the diet [ 61 , 62 ]. However, finding the threshold to which there are still benefits from taking nutritional supplements, vitamins, and medications is always challenging.…”

Section: Importance Of Dosagementioning

confidence: 99%

Update on Omega-3 Polyunsaturated Fatty Acids on Cardiovascular Health

Rodriguez¹,

Lavie²,

Elagizi³

et al. 2022

Nutrients

View full text Add to dashboard Cite

Twenty percent of deaths in the United States are secondary to cardiovascular diseases (CVD). In patients with hyperlipidemia and hypertriglyceridemia, studies have shown high atherosclerotic CVD (ASCVD) event rates despite the use of statins. Given the association of high triglyceride (TG) levels with elevated cholesterol and low levels of high-density lipoprotein cholesterol, the American Heart Association (AHA)/American College of Cardiology (ACC) cholesterol guidelines recommend using elevated TGs as a “risk-enhancing factor” for ASCVD and using omega 3 fatty acids (Ω3FAs) for patients with persistently elevated severe hypertriglyceridemia. Ω3FA, or fish oils (FOs), have been shown to reduce very high TG levels, hospitalizations, and CVD mortality in randomized controlled trials (RCTs). We have published the largest meta-analysis to date demonstrating significant effects on several CVD outcomes, especially fatal myocardial infarctions (MIs) and total MIs. Despite the most intensive research on Ω3FAs on CVD, their benefits have been demonstrated to cluster across multiple systems and pathologies, including autoimmune diseases, infectious diseases, chronic kidney disease, central nervous system diseases, and, most recently, the COVID-19 pandemic. A review and summary of the controversies surrounding Ω3FAs, some of the latest evidence-based findings, and the current and most updated recommendations on Ω3FAs are presented in this paper.

show abstract

“…We also report the levels of other RBCM FAs measured as wt% to eliminate differences in RBCM amounts, which may vary between individual blood sampling, even in the same person. However, since there is no agreement on the choice of FA measure (absolute vs. relative) [85,88,89], data on the concentrations (mg/mL) of RBCM FAs are reported in the Supporting Information.…”

Section: Biochemical Variables 2111 Fatty Acid Profiles In Rbcmsmentioning

confidence: 99%

Changes in lipoprotein particle subclasses, standard lipids, and apolipoproteins after supplementation with n-3 or n-6 PUFAs in abdominal obesity: A randomized double-blind crossover study

et al. 2021

View full text Add to dashboard Cite

show abstract

Absolute versus relative measures of plasma fatty acids and health outcomes: example of phospholipid omega-3 and omega-6 fatty acids and all-cause mortality in women

Cited by 18 publications

References 29 publications

A Comprehensive Review of Chemistry, Sources and Bioavailability of Omega-3 Fatty Acids

A Comprehensive Review of Chemistry, Sources and Bioavailability of Omega-3 Fatty Acids

Update on Omega-3 Polyunsaturated Fatty Acids on Cardiovascular Health

Changes in lipoprotein particle subclasses, standard lipids, and apolipoproteins after supplementation with n-3 or n-6 PUFAs in abdominal obesity: A randomized double-blind crossover study

Contact Info

Product

Resources

About