Absorbent-force-driven microflow cytometer

Lee, Yan-Chang; Hsieh, Wen‐Hsin

doi:10.1016/j.snb.2014.05.117

Cited by 10 publications

(9 citation statements)

References 46 publications

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“…44,88 Synthetic microfluidic paper with well-controlled arrays of interlocked micropillars was developed in polymer and demonstrated to provide improved performance compared to conventional porous materials. 64 Hydrogels 90 and superabsorbent polymers 91,92 were also used as pumps to drive capillary-driven flow.…”

Section: Capillary Pumpmentioning

confidence: 99%

Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits

et al. 2018

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Microfluidics offer economy of reagents, rapid liquid delivery, and potential for automation of many reactions, but often require peripheral equipment for flow control. Capillary microfluidics can deliver liquids in a pre-programmed manner without peripheral equipment by exploiting surface tension effects encoded by the geometry and surface chemistry of a microchannel. Here, we review the history and progress of microchannel-based capillary microfluidics spanning over three decades. To both reflect recent experimental and conceptual progress, and distinguish from paper-based capillary microfluidics, we adopt the more recent terminology of capillaric circuits (CCs). We identify three distinct waves of development driven by microfabrication technologies starting with early implementations in industry using machining and lamination, followed by development in the context of micro total analysis systems (μTAS) and lab-on-a-chip devices using cleanroom microfabrication, and finally a third wave that arose with advances in rapid prototyping technologies. We discuss the basic physical laws governing capillary flow, deconstruct CCs into basic circuit elements including capillary pumps, stop valves, trigger valves, retention valves, and so on, and describe their operating principle and limitations. We discuss applications of CCs starting with the most common usage in automating liquid delivery steps for immunoassays, and highlight emerging applications such as DNA analysis. Finally, we highlight recent developments in rapid prototyping of CCs and the benefits offered including speed, low cost, and greater degrees of freedom in CC design. The combination of better analytical models and lower entry barriers (thanks to advances in rapid manufacturing) make CCs both a fertile research area and an increasingly capable technology for user-friendly and high-performance laboratory and diagnostic tests.

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Section: Capillary Pumpmentioning

confidence: 99%

Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits

et al. 2018

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“…Moreover, Lee et al. presented an absorbent‐force‐driven microflow cytometer chip, in which solution was driven by the absorbent force of superabsorbent materials. All aforementioned methods have a common feature that they are power‐free or need limited external power, which is beneficial to the portability and popularization.…”

Section: Flow Control In Microfluidic Flow Cytometrymentioning

confidence: 99%

“…In addition, some other methods were used to generate fluid flow in micro total analysis system (TAS) [38], such as redox-magnetohydrodynamics pumping [39,40], molecular motors pumping [41,42], bio-inspired biomimetic pumping [43], bio-actuated pumping [44], and hydrophilic sponges for leaf-inspired continuous pumping [45]. Moreover, Lee et al [46] presented an absorbent-force-driven microflow cytometer chip, in which solution was driven by the absorbent force of superabsorbent materials. All aforementioned methods have a common feature that they are power-free or need limited external power, which is beneficial to the portability and popularization.…”

Section: Flow Control In Microfluidic Flow Cytometry 21 Sample Pumpingmentioning

confidence: 99%

New advances in microfluidic flow cytometry

Gong

Fan

et al. 2018

Electrophoresis

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In recent years, researchers are paying the increasing attention to the development of portable microfluidic diagnostic devices including microfluidic flow cytometry for the point‐of‐care testing. Microfluidic flow cytometry, where microfluidics and flow cytometry work together to realize novel functionalities on the microchip, provides a powerful tool for measuring the multiple characteristics of biological samples. The development of a portable, low‐cost, and compact flow cytometer can benefit the health care in underserved areas such as Africa or Asia. In this article, we review recent advancements of microfluidics including sample pumping, focusing and sorting, novel detection approaches, and data analysis in the field of flow cytometry. The challenge of microfluidic flow cytometry is also examined briefly.

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“…In cases where low flow velocity or sufficiently long reaction time is needed and/or the volume of solutions is relatively large, a large (specific) surface area will be required by the paper materials. This problem can be solved by using a superabsorbent polymer (SAP) [ 18 , 19 ], which is known to absorb and hold distilled water 10–1000 times its dry weight [ 20 , 21 ]. The SAP, along with paper material that shows the risk of back-flow of solution, could assist in running the multi-step (i.e.…”

Section: Introductionmentioning

confidence: 99%

A simple micropump based on a freeze-dried superabsorbent polymer for multiplex solution processing in disposable devices

et al. 2019

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We describe a simple micropump for disposable microfluidic devices. The pump is constructed using a freeze-dried disc of a superabsorbent polymer (SAP). The disc absorbs a solution in a flow channel and swells upward in a pumping chamber. Despite the simple structure of this device, the rate of absorption remains constant and can be adjusted by changing the composition of the SAP, its size, the dimensions of the flow channel and the medium to be absorbed. The pumping action can be initiated by applying an electrical signal using a switchable hydrophobic valve. The integrated approach of the SAP pump and switchable valve could facilitate the automatic processing of many solutions required for bioassay.

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Absorbent-force-driven microflow cytometer

Cited by 10 publications

References 46 publications

Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits

Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits

New advances in microfluidic flow cytometry

A simple micropump based on a freeze-dried superabsorbent polymer for multiplex solution processing in disposable devices

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