Absorption and Graft Function After Small-Intestinal Transplantation

Cohen, Zane; Wassef, Ramsès; Nordgren, Svante; Silverman, Rafael

doi:10.1007/978-3-642-71087-2_14

Cited by 3 publications

(5 citation statements)

References 6 publications

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“…Although lymphatics should be regenerated within 2-4 weeks after transplantation [1], fat digestibility was lower in the digestibility trials a few weeks after transplantation. Surgery had no significant effect on the absorption of carbohydrates despite the results obtained with glucose or xylose tolerance tests [5,29,33] or on protein digestion similar to the findings of Seifert and Deltz [38]. Only part of the effects on digestion by the surgical procedure can be attributed to the partial resection of the small-bowel (cf.…”

Section: Effects On Digestion and Absorption As Caused By The Procedusupporting

confidence: 48%

“…Effects of surgery on absorption can be separately simulated by autotransplantation [e.g., 1,5,29,43], denervation [33,44], or disruption of the lymphatics. Denervation was demonstrated to impair electrolyte and water absorption more than the absorption of organic nutrients [32], whereas absorption of fat and fat-soluble substances is severely affected by lymphatic disruption [1].…”

Section: Effects On Digestion and Absorption As Caused By The Procedumentioning

confidence: 99%

“…The protective action of cyclosporine against the rejection of small-bowel grafts was confirmed in the present study since digestibility was severely depressed only when no initial cyclosporine treatment was carried out. With chronic or acute rejection, the digestion and absorption of all nutrients fall rapidly, as has been demonstrated in detail for fat and fat-soluble substances [5,39,43], for carbohydrates [2,5,21,33,44], for proteinaceous compounds [44], and for electrolytes [8,44]. Death occurs immediately after the mucous membrane is destroyed by the rejection process [11] and absorption becomes impossible [3].…”

Section: Long-term Effects Of Transplantation and Effects Of Rejectiomentioning

confidence: 99%

“…Death occurs immediately after the mucous membrane is destroyed by the rejection process [11] and absorption becomes impossible [3]. There is a good agreement between the extent of depression in absorption and the histological statement [5]. In rejection, function of the lymphatics might be especially disturbed, leading to an even more pronounced depression of fat digestion than that observed without rejection and thus to a reduced efficiency of oral treatment with cyclosporine which is fat-soluble.…”

Section: Long-term Effects Of Transplantation and Effects Of Rejectiomentioning

confidence: 99%

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Quantitative effects of allogeneic small-bowel transplantation of nutrient digestion and on body protein balance as determined in vivo in rats

et al. 1990

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Heterotopic and orthotopic small-bowel allotransplantation was carried out in Wistar rats using grafts reduced to one-half of the original length. Portocaval venous anastomoses and intestinal end-to-end anastomoses were performed. Animals either with complete or with partially reduced native small-bowel served as control. In a total of 51 rats, 88 quantitative in vivo measurements of apparent digestion and absorption of dietary dry matter, organic matter, energy, protein, fat, total ash, and glucose were carried out. Body protein retention was calculated from intake and losses with feces and urine. The digestion trials comprised 8 days of adaptation and 10 days of continual recording of nutrient balance data. In experiments 1 and 2, digestibility coefficients were obtained before and after transplantation within the same animals, untreated or initially treated with cyclosporine A after surgery. Similar groups of rats untreated, with partial resection and with transplantation of the small-bowel, followed by temporary cyclosporine treatment, were used in experiment 3. In experiment 4, rats with transplanted intestines from experiments 1 and 2 were subjected to a further digestion trial 4 to 6 months after the respective first trial. With transplantation of the small intestine, apparent digestion and absorption of nutrients, as well as protein retention, tended to be lower. Significant depression occurred in the digestion of fat and ash. In long-term survivors all parameters decreased further. The adverse effects on fat and ash digestion seemed to be pronounced when rejection occurred. Fecal fat excretion might therefore be an indication of dysfunction of small-bowel grafts. Digestion was less imparied if cyclosporine was applied, and part of the effects on digestion and protein balance could be attributed to the shortened bowel.

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Section: Effects On Digestion and Absorption As Caused By The Procedusupporting

confidence: 48%

Section: Effects On Digestion and Absorption As Caused By The Procedumentioning

confidence: 99%

Section: Long-term Effects Of Transplantation and Effects Of Rejectiomentioning

confidence: 99%

Section: Long-term Effects Of Transplantation and Effects Of Rejectiomentioning

confidence: 99%

See 2 more Smart Citations

Quantitative effects of allogeneic small-bowel transplantation of nutrient digestion and on body protein balance as determined in vivo in rats

et al. 1990

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“…49], but little was known or learned about the absolute rate of uptake as compared with neurally intact controls. More recently, glucose absorption has been quantitated as 'normal' in pigs [38] and markedly de creased [50] or slightly decreased [51] in rats. Wood and colleagues [25, 26.…”

Section: Nutrient Absorptionmentioning

confidence: 99%

Enteric Physiology of the Transplanted Gut: Absorption and Motility

Sarr¹

1996

Dig Surg

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Tremendous progress has been made recently in small bowel transplantation. However, our understanding of the enteric function of the transplanted gut remains in its infancy. Unlike many of the other organs commonly transplanted, the function of the transplanted gut appears to be markedly affected by the consequences of the transplantation procedure (denervation, lymphatic disruption, and immune phenomena). This review discusses the effects of gut transplantation on segmental enteric function, concentrating on absorption and motility. Once many of the problems related to the current means of immunosuppression have been better solved, gut transplantation may prove to be an important addition for gastrointestinal surgeons to the care of patients with intestinal insufficiency.

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Small-bowel transplantation

Schwartz

1988

Pediatr Surg Int

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Absorption and Graft Function After Small-Intestinal Transplantation

Cited by 3 publications

References 6 publications

Quantitative effects of allogeneic small-bowel transplantation of nutrient digestion and on body protein balance as determined in vivo in rats

Quantitative effects of allogeneic small-bowel transplantation of nutrient digestion and on body protein balance as determined in vivo in rats

Enteric Physiology of the Transplanted Gut: Absorption and Motility

Small-bowel transplantation

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