With the advent of precision agriculture, it was possible to integrate several technologies to develop the variable rate application (VRA). The use of VRA allows savings in the use of herbicides, better weed control, lower environmental impact and, indirectly, increased crop productivity. There are VRA techniques based on maps and sensors for herbicide application in preemergence (PRE) and postemergence (POST). The adoption of the type of system will depend on the investment capacity of the producer, skilled workforce available, and the modality of application. Although it still has some limitations, VRA has been widespread and has been occupying more and more space in chemical management, the tendency in the medium- and long term is that there is a gradual replacement of the conventional method of application. Given the benefits provided by VRA along with the engagement of companies and researchers, there will be constant evolution and improvement of this technology, cheapening the costs of implementation and providing its adoption by an increasing number of producers. Thus, the objective of this chapter was to address an overview of the use of herbicides in VRA for weed management in PRE and POST.