Absorption, metabolism, and functions of hyaluronic acid and its therapeutic prospects in combination with microorganisms: A review

Zheng, Xiaojiao; Wang, Botao; Tang, Xin Yue; Mao, Bingyong; Zhang, Qiuxiang; Zhang, Tianmeng; Zhao, Jianxin; Cui, Shumao; Chen, Wei

doi:10.1016/j.carbpol.2022.120153

Cited by 33 publications

(11 citation statements)

References 206 publications

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“…Typically, small-molecule degradation products follow three primary metabolic pathways: (1) metabolic processes within surrounding cells, where they can undergo further breakdown or conversion into metabolites that enter the nucleus or cytoplasm; (2) transport of small-molecule products through lymphatic fluid to other tissues or organs for subsequent metabolism; and (3) metabolism and eventual excretion via the bloodstream through vital organs including the liver or kidneys. 56,57 Moreover, the suitability of degradation products for specific tissue repair applications, such as bone or muscle tissue repair, must be critically evaluated, considering the unique requirements and challenges of each tissue type. In the context of bone tissue repair applications, degradation products require greater stability due to the potentially extended duration of the implant and for complete absorption or metabolism.…”

Section: Evaluation Of Degradation Capacitymentioning

confidence: 99%

Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine

Jia,

Huang,

Dong

et al. 2024

Chem. Soc. Rev.

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Section: Evaluation Of Degradation Capacitymentioning

confidence: 99%

Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine

Jia,

Huang,

Dong

et al. 2024

Chem. Soc. Rev.

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“…[ 81 ] But unlike the above kinds of stimuli‐responsive hydrogel materials, HA is a crucial ingredient to make up the human body and indispensable for organ constitution (e.g., skin, synovial fluid, vitreous body) and tissue repairing. [ 82 ] As the development of biotechnology and gene engineering, nowadays HA is mainly produced by microbial fermentation instead of direct extraction from animal tissues, which is the precondition of the wide use of HA. [ 83 ] In recent years, HA has become a frequently‐used hydrogel biomaterial with abundant products in the medical area such as HA‐based dermal filler, eye drops, and viscoelastic agent for ocular surgery.…”

Section: Commonly Used Materials In the Preparation Of Stimulus‐respo...mentioning

confidence: 99%

Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy

Yu,

Gao,

Liu

et al. 2023

Advanced Science

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Deregulated inflammations induced by various factors are one of the most common diseases in people's daily life, while severe inflammation can even lead to death. Thus, the efficient treatment of inflammation has always been the hot topic in the research of medicine. In the past decades, as a potential biomaterial, stimuli‐responsive hydrogels have been a focus of attention for the inflammation treatment due to their excellent biocompatibility and design flexibility. Recently, thanks to the rapid development of nanotechnology and material science, more and more efforts have been made to develop safer, more personal and more effective hydrogels for the therapy of some frequent but tough inflammations such as sepsis, rheumatoid arthritis, osteoarthritis, periodontitis, and ulcerative colitis. Herein, from recent studies and articles, the conventional and emerging hydrogels in the delivery of anti‐inflammatory drugs and the therapy for various inflammations are summarized. And their prospects of clinical translation and future development are also discussed in further detail.

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“…Hyaluronic acid (HA) is an important component of the extracellular matrix involved in various biological and pathological processes, including tissue injury and repair, immune responses and inflammatory reactions ( Liang et al., 2016 ; Zheng et al., 2023 ). Accumulating evidence suggests that HA plays an important role in the inflammatory process, it could be considered an inflammatory biomarker.…”

Section: Introductionmentioning

confidence: 99%

Elevated hyaluronic acid levels in severe SARS-CoV-2 infection in the post-COVID-19 era

Li,

Cui,

Zhu

et al. 2024

Front. Cell. Infect. Microbiol.

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ObjectiveHuman identical sequences of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) promoted the coronavirus disease 2019 (COVID-19) progression by upregulating hyaluronic acid (HA) via NamiRNA-enhancer network, based on previous experimental research. This study aimed to investigate the predictive value of HA for the severity of SARS-CoV-2 infection in the post-COVID-19 era.MethodsA total of 217 consecutive patients with COVID-19 were enrolled at Beijing Ditan Hospital between July 2023 and October 2023. HA levels were analyzed using biochemical detector. Logistic regression analysis was used to screen independent factors for severe COVID-19. The predictive performance of HA for severe infection was assessed by ROC curve. Furthermore, the relationship between HA levels and COVID-19 severity was investigated using multivariate logistic regression models after adjustment for potential confounders.ResultsAccording to the cut-off value of HA, COVID-19 patients were divided into HA < 90 ng/mL group (80 cases) and HA ≥ 90 ng/mL group (137 cases). High HA levels were positively associated with the severe SARS-CoV-2 infection, including elevated inflammatory indicators, severe lung involvement, prolonged clinical course, and higher incidence of respiratory failure and death (P < 0.05). Logistic regression analysis suggested that HA was an independent predictor of severe COVID-19 (OR = 4.540, 95% CI = 2.105-9.790, P < 0.001). ROC curve analysis showed that the AUC of HA for severe infection was 0.724. HA levels were significantly higher in COVID-19 cases compared to the healthy population (123.9 (82.6, 174.1) vs. 50.5 (37.8, 66.8), P < 0.001), but similar to those with non-SARS-CoV-2 lung infection (121.6 (78.5, 175.6) vs. 106.0 (66.5, 149.7), P = 0.244). We also found that the first COVID-19 infections had higher HA levels (118.8 (79.5, 174.3) vs. 85.0 (61.1, 128.8), P < 0.001) and a higher proportion of severe infection (37.1% vs. 21.3%, P = 0.043) than re-infections. However, HA expression failed to fully return to normal levels with infection recovery (204.7 (152.9, 242.2) vs. 97.0 (69.3, 137.3), P < 0.001).ConclusionHA was associated with severe SARS-CoV-2 infection and could be used as a novel serum biomarker to predict the risk of COVID-19 progression in the post-COVID-19 era.

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Absorption, metabolism, and functions of hyaluronic acid and its therapeutic prospects in combination with microorganisms: A review

Cited by 33 publications

References 206 publications

Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine

Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine

Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy

Elevated hyaluronic acid levels in severe SARS-CoV-2 infection in the post-COVID-19 era

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