Absorption of Dietary Calcium in Pregnancy

Shenolikar, I.S.

doi:10.1093/ajcn/23.1.63

Cited by 47 publications

(14 citation statements)

References 6 publications

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“…In fact, physiological changes in calcium absorption are known to occur in response to an increased calcium need of the body (8,9). However, in the present study no improvement of calcium absorption was observed in late pregnancy , and absorption during this period was considerably less than during early-mid pregnancy (Table 5).…”

Section: Discussioncontrasting

confidence: 69%

Effects of various levels of dietary calcium during pregnancy on maternal calcium utilization and fetal growth in rats.

Lai

Ito

Komatsu

et al. 1984

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe effects of calcium-free and normal (0.6%) and high (1.0%) calcium diets on the transfer of calcium from pregnant mothers to fetuses were investigated by balance experiments. Pregnant rats receiving calcium-free, normal and high calcium diets ate totals of 353, 324 and 280g of the diet, respectively, during pregnancy, and the food con sumption of the latter two groups decreased near term. The group on calcium-free diet was able to maintain pregnancy and produce normal fetuses by using calcium resorbed from the dam's bones. The calcium retentions due to pregnancy in rats on normal and high calcium diets were 116 and 128 mg, respectively, during the first 15 days, and -9 and -109mg , respectively, during the last 6 days of pregnancy. Fetuses contained about 130mg of calcium at term and most of this calcium was supplied from the dam's bones, in which extra calcium were retained during early-mid pregnancy. Unexpectedly, the true rate of calcium absorption was appreciably lower during late pregnancy than during early-mid pregnancy in both dietary groups. Thus, extra calcium retention during early-mid pregnancy seemed to be physiological adaptation to a decrease in either food consumption or calcium absorption during late pregnancy. Phosphorus absorption and its balance were examined in relation with the dietary calcium levels.

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Section: Discussioncontrasting

confidence: 69%

Effects of various levels of dietary calcium during pregnancy on maternal calcium utilization and fetal growth in rats.

Lai

Ito

Komatsu

et al. 1984

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

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“…If these data were confirmed, an alternative explanation could be found in an altered sensitivity of the target organs, as is known for other hormones and even for 1,25-(OH)2D3 receptors (45). Another study could not reveal, however, an increased calcium absorption in the first trimester of pregnancy (46).…”

Section: Resultsmentioning

confidence: 87%

Influence of the Vitamin D-binding Protein on the Serum Concentration of 1,25-Dihydroxyvitamin D3

Bouillon¹,

Assche²,

Baelen³

et al. 1981

J. Clin. Invest.

501

260

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A B S T R A C T The influence of the serum binding protein (DBP) for vitamin D and its metabolites on the concentration of its main ligands, 25-hydroxyvitamin D3 (25-OHD3) and 1,25-dihydroxyvitamin D3 (1,25-[OHh2D3) was studied. The concentration of both 1,25-(OH)2D3 and DBP in normal female subjects (45±14 ng/liter and 333±58 mg/liter, mean+SD, respectively; n = 58) increased during the intake of estro-progestogens (69±27 ng/liter and 488±90 mg/liter, respectively; n = 29), whereas the 25-OHD3 concentration remained unchanged. A positive correlation was found between the concentrations of 1,25-(OH)2D3 and DBP in these women.At the end of pregnancy, the total concentrations of 1,25-(OH)2D3 (97±26 ng/liter, n = 40) and DBP (616 ±84 mg/liter) are both significantly higher than in nonpregnant females and paired cord serum samples (48±11 ng/liter and 266±41 mg/liter, respectively). A marked seasonal variation of 25-OHD3 was observed in pregnant females and their infants, whereas in the same samples the concentrations of both DBP and 1,25-(OH)2D3 remained constant throughout the year.The free 1,25-(OH)2D3 index, calculated as the molar ratio ofthis steroid and DBP, remains normal in women taking estro-progestogens, however, and this might explain their normal intestinal calcium absorption despite a high total 1,25-(OH)2D3 concentration. In pregnancy the free 1,25-(OH)2D3 index remains normal up to 35 wk of gestation, but during the last weeks of Part of this work was presented at

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“…The pregnant subject also loses cal cium to the fetus. However, the loss of cal cium is antagonized by increased gastrointes tinal absorption [Shenolikar, 1970;Heaney and Skillman, 1971], and it is not so large that a reduction in the calcium content of the skeleton has been detected [Goldsmith and Johnston, 1975;Christiansen et al" 1976], although one report [Lamke et al, 1977] showed a reduction in trabecular bone of approximately 4% during gestation. Thus the tendency to calcium deficiency during nor mal pregnancy is evidently at least partly compensated by the increased gastrointesti nal calcium absorption.…”

Section: Discussionmentioning

confidence: 99%

Calcium, Parathyroid Hormone and Calcitonin in Normal Pregnancy and Preeclampsia

Eb¹,

Johannesen²,

Kristensen³

et al. 1984

Gynecol Obstet Invest

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Calcium, parathyroid hormone (PTH) and calcitonin (CT) in serum, and the fractional renal excretion of calcium (FE_Ca) were determined in (1) normal pregnant women, (2) patients with preeclampsia, and (3) normal nonpregnant control subjects. Serum calcium, corrected for individual variation in serum protein, was reduced and FE_Ca increased in the normal pregnant group when compared to the nonpregnant control group. In preeclampsia serum calcium did not differ significantly from the normal pregnant group, but FE_Ca was considerably lower and also reduced below the level in the nonpregnant control group. PTH was slightly lower during normal pregnancy than after delivery, but did not deviate significantly from the nonpregnant control group; in preeclampsia PTH did not deviate significantly from the levels in normal pregnancy. CT was the same in the third trimester of pregnancy in both groups. Changes in serum calcium and FE_Ca were not correlated to PTH or CT. It is concluded that both normal pregnancy and preeclampsia are accompanied by considerable alterations in calcium metabolism, that PTH and CT in both groups are mainly unchanged and at nonpregnant level, and that the increase and decrease in renal calcium excretion in normal pregnancy and preeclampsia, respectively, may be attributed to changes in kidney function.

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Absorption of Dietary Calcium in Pregnancy

Cited by 47 publications

References 6 publications

Effects of various levels of dietary calcium during pregnancy on maternal calcium utilization and fetal growth in rats.

Effects of various levels of dietary calcium during pregnancy on maternal calcium utilization and fetal growth in rats.

Influence of the Vitamin D-binding Protein on the Serum Concentration of 1,25-Dihydroxyvitamin D3

Calcium, Parathyroid Hormone and Calcitonin in Normal Pregnancy and Preeclampsia

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