Absorption of Effervescent Aspirin during Migraine

Volans, Glyn N.

doi:10.1136/bmj.4.5939.265

Cited by 107 publications

(83 citation statements)

References 8 publications

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“…The present findings have wide therapeutic implications. There is an increasing awareness of the role of gastric emptying rate in influencing the absorption of orally administered drugs (Heading et al, 1973;Nimmo et al, 1973;Finch, Kendall & Mitchard, 1974;Volans, 1974;Ahmad, 1974).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of gastric emptying and drug absorption by narcotic analgesics.

Nimmo¹,

Heading²,

Wilson³

et al. 1975

Brit J Clinical Pharma

256

115

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Section: Discussionmentioning

confidence: 99%

Inhibition of gastric emptying and drug absorption by narcotic analgesics.

Nimmo¹,

Heading²,

Wilson³

et al. 1975

Brit J Clinical Pharma

256

115

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“…Recent investigations have demonstrated impairment of the rate of absorption of effervescent aspirin during migraine attacks (Volans, 1974b). It is thought that impaired drug absorption during migraine may be the cause of many cases of therapeutic failure (Wilkinson, 1971) and it is probable that a treatment which improved the rate of drug absorption would be of clinical relevance.…”

Section: Introductionmentioning

confidence: 99%

The effect of metoclopramide on the absorption of effervescent aspirin in migraine.

Volans¹

1975

Brit J Clinical Pharma

134

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1 The absorption of effervescent aspirin was studied in two groups of patients during attacks of migraine. The first group received effervescent aspirin alone whilst the second group received intramuscular metoclopramide before effervescent aspirin. 2 After effervescent aspirin alone there was significant impairment in the rate of aspirin absorption during migraine attacks compared with the rate of aspirin absorption in normal volunteers and in the same patients when headache‐free. 3 When metoclopramide was given before effervescent aspirin the rate of aspirin absorption during migraine attacks was not significantly different from that obtained in normal volunteers given effervescent aspirin alone or from that obtained in the patients themselves when given both metoclopramide and effervescent aspirin when headache‐free. 4 It is concluded that the impairment of absorption of effervescent aspirin during migraine attacks is related to impaired gastro‐intestinal motility with delayed gastric emptying and that this impaired motility can be overcome by parenteral metoclopramide.

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“…During migraine attacks the stomach is relatively atonic and the absorption of orally administered drugs is delayed [32], but the absorption can be normalised by the prokinetic and anti-emetic drug metoclopramide [33]. The combination of lysine acetylsalicylic acid and metoclopamide (56%) was as effective as sumatriptan 100 mg (53% relief) and both were superior to placebo (24%) in one RCT [34].…”

Section: Use Of Prokinetic Drugs and Neurolepticsmentioning

confidence: 99%

Acute pharmacotherapy of migraine, tension-type headache, and cluster headache

Tfelt‐Hansen

2007

J Headache Pain

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In most migraine patients acute therapy is needed. Migraine can be treated either with specific drugs, the triptans and ergot alkaloids, or with NSAIDs. Triptans are a major step foreward in migraine therapy. The therapeutic gain for headache relief is 50% for subcutaneous sumatriptan whereas it is 30-40% for most oral triptans. After oral triptans sustained pain free is only 30%. There is thus still ample room for improvement of acute therapy in migraine. For tension-type headache there is no specific therapy and it is treated with NSAIDs. Only 17-32% become pain free after these drugs. For attacks of cluster headache oxygen and subcutaneous sumatriptan can be used. Intranasal triptans can be an alternative.

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Absorption of Effervescent Aspirin during Migraine

Cited by 107 publications

References 8 publications

Inhibition of gastric emptying and drug absorption by narcotic analgesics.

Inhibition of gastric emptying and drug absorption by narcotic analgesics.

The effect of metoclopramide on the absorption of effervescent aspirin in migraine.

Acute pharmacotherapy of migraine, tension-type headache, and cluster headache

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