Absorption of Isosorbide Dinitrate by PVC Infusion Bags and Administration Sets

Lee, M. G.; Fenton-May, V’Iain

doi:10.1111/j.1365-2710.1981.tb00995.x

Cited by 4 publications

(2 citation statements)

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“…Infants particularly are vulnerable to changes in drug dosage concentrations because of their size and sensitivity to drugs. Patients with significant cardiovascular disease may be compromised because nitroglycerine or isosorbide adheres to PVC extension tubing and reduces the delivered dose [ 2, 9].…”

Section: Discussionmentioning

confidence: 99%

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A qualitative investigation into the physical stability of polypropylene and polyethylene in liquid isoflurane and sevoflurane

Renfrew

Murray²,

Fee

2000

Anaesthesia

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The interaction between medical plastics and drugs is complex. Drug absorption into plastics may affect drug dosage and the migration of plastics' additives into a drug solution may affect drug composition. We investigated the stability of those plastics which may be used in infusion systems to inject liquid volatile anaesthetic drugs directly into an anaesthetic breathing system. Samples of two types of polypropylene from a syringe barrel and plunger and low‐ and high‐density polyethylene from extension tubing were exposed to isoflurane and sevoflurane for 1, 7 or 250 days. All samples were from the same batches. Samples of the plastics (n = 24) and the liquid volatile anaesthetics (n = 24) were subjected to Fourier transform‐infrared spectroscopy to produce series of absorption spectra. By reference to control sample absorption spectra, this allows detection of anaesthetic drug absorption into the plastics or migration of the plastics or their additives into the liquid anaesthetics. We found no evidence of migration of the plastic components or their additives into the liquid anaesthetic drugs at any of the exposure periods. Similarly, we found no evidence of absorption of isoflurane or sevoflurane by any of the plastic components during short‐term exposure of either 1 or 7 days. However, there was evidence of some absorption of the anaesthetic drugs by the polyethylene plastics after about 8 months' exposure. It would appear that low‐ and high‐density polyethylene and polypropylene are suitably safe for use in infusion systems for the direct injection of isoflurane and sevoflurane into anaesthetic breathing systems.

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Section: Discussionmentioning

confidence: 99%

“…during the first few hours of infusion. Rapidly changing drug effect when using PVC administration systems is well documented for nitroglycerine [ 10], isosorbide dinitrate [ 9] and diazepam [ 11]. There are also significant losses of insulin [ 12], clonazepam [ 13] and chlormethiazole [ 14] in PVC systems.…”

Section: Discussionmentioning

confidence: 99%