Absorption of N4-d-glucopyranosylsulphamethazine by rat everted intestinal sacs

Wang, Yi; Grigg, R.; Mccormack, A. J.; Symonds, H.W.; Bowmer, C J

doi:10.1016/0006-2952(93)90595-n

Cited by 20 publications

(2 citation statements)

References 5 publications

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“…Healthy male Sprague-Dawley (SD) rat (6)(7)(8) week-old, 250 AE 20 g), a recognized animal model used for pharmacokinetic study, were supplied by the Animal Center of Capital Medical University (ACCMU, Beijing, China). The rats were housed in a room with controlled illumination (a 12 h light and dark cycle), temperature (22 AE 2 C) and 23% relative humidity for one week to acclimatize.…”

Section: Animalsmentioning

confidence: 99%

“…Considering SAL belongs to the phenolic glycoside family, some researchers suggest that glucose transporters may be involved in the absorption of SAL. [5][6][7][8] He et al suggested that sodium-dependent glucose transporter (SGLT1) plays an important role in the absorption of SAL in rats. 9 Findings from literature and our preliminary studies both suggested that aer oral administration of SAL to rats, more than 50% of the parent compound undergoes deglycosylation and sulfation.…”

Section: Introductionmentioning

confidence: 99%

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Cytosolic β-glucosidase inhibition and renal blood flow suppression are leading causes for the enhanced systemic exposure of salidroside in hypoxic rats

Zhao

et al. 2018

RSC Adv.

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Section: Animalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cytosolic β-glucosidase inhibition and renal blood flow suppression are leading causes for the enhanced systemic exposure of salidroside in hypoxic rats

Zhao

et al. 2018

RSC Adv.

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Regulation of Cytochromes P450 by Substrate Interactions

Ingelman‐Sundberg¹,

Жуков²,

Mkrtchian³

et al. 1994

Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research

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Ökotoxikologische und humantoxikologische Risikobewertung PAK-belasteter Böden vor und nach biologischer Behandlung

Roos

Weissenfels²,

Afferden

et al. 2000

UWSF - Z Umweltchem Ökotox

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Ecotoxicological and Human Toxicological Risk Assessment of PAH-contaminated Soils Before and After Biological TreatmentThe goal of the present work is to assess the adverse effects of soil bound polycyclic aromatic hydrocarbons (PAH) which remain in soils after biological remediation. We focus on risk assessment for mammalian species with respect to the oral uptake of contaminated soil particles and compare the results of a biomarker test with those of an ecotoxicological assay, the bioluminescence inhibition test with Vibrio fischeri. As a biomarker effect in mammals, we determined the liver microsomal cytochrome P450 enzyme CYPIA1 which is induced by PAH in exposed rats. After biological soil treatment, different amounts of PAH remain in the soil depending on the soil properties and initial pollutant composition. Particularly, higher condensated PAH resists biological treatment due to its hydrophobicity. In addition, high amounts of organic carbon in the soils affect remediation efficiency. In the bioluminescence inhibition test, eluates of all biologically treated soils studied do not reveal any or only low inhibitory effects. In contrast, the oral uptake of biologically treated contaminated soils leads to induction levels for CYPIA1 similar to those in the untreated samples. A good correlation is obtained between CYPIA1 levels and the amount of 5 and 6-ring PAH in the soil samples. The main result is that the remediation efficiency determined by the luminescence test is not reflected by the biomarker test, a finding which indicates the high bioavailabiliry of residual PAH in soils. Consequently, new criteria for human risk assessment can be delineated,

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Absorption of N4-d-glucopyranosylsulphamethazine by rat everted intestinal sacs

Cited by 20 publications

References 5 publications

Cytosolic β-glucosidase inhibition and renal blood flow suppression are leading causes for the enhanced systemic exposure of salidroside in hypoxic rats

Cytosolic β-glucosidase inhibition and renal blood flow suppression are leading causes for the enhanced systemic exposure of salidroside in hypoxic rats

Regulation of Cytochromes P450 by Substrate Interactions

Ökotoxikologische und humantoxikologische Risikobewertung PAK-belasteter Böden vor und nach biologischer Behandlung

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