Absorption of Orally Administered Hyaluronan

Kimura, Mamoru; Maeshima, Takuya; Kubota, Takumi; Kurihara, Hitoshi; Masuda, Yasunobu; Nomura, Yasuya

doi:10.1089/jmf.2016.3725

Cited by 45 publications

(39 citation statements)

References 34 publications

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“…For a long time, the fact that HA can cross in its “intact” form the intestinal barrier has been debated; recently, a few studies have appeared in the literature to highlight this question. Kimura et al have evaluated the degradation and absorption of HA (300 KDa and 2 KDa) after oral ingestion in rats, demonstrating intestinal degradation to oligosaccharides, which are subsequently absorbed in the large intestine, translocated into the blood and distributed in the skin [248]. Orally-ingested LMW HA has shown the opposite effects: some studies have reported inflammatory properties with the activation of the immune response [249], while other research has highlighted the efficacy in reducing knee joint pain without inflammation [250].…”

Section: Applications Of Ha and Its Derivativesmentioning

confidence: 99%

Hyaluronic Acid in the Third Millennium

et al. 2018

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Abstract:Since its first isolation in 1934, hyaluronic acid (HA) has been studied across a variety of research areas. This unbranched glycosaminoglycan consisting of repeating disaccharide units of N-acetyl-D-glucosamine and D-glucuronic acid is almost ubiquitous in humans and in other vertebrates. HA is involved in many key processes, including cell signaling, wound reparation, tissue regeneration, morphogenesis, matrix organization and pathobiology, and has unique physico-chemical properties, such as biocompatibility, biodegradability, mucoadhesivity, hygroscopicity and viscoelasticity. For these reasons, exogenous HA has been investigated as a drug delivery system and treatment in cancer, ophthalmology, arthrology, pneumology, rhinology, urology, aesthetic medicine and cosmetics. To improve and customize its properties and applications, HA can be subjected to chemical modifications: conjugation and crosslinking. The present review gives an overview regarding HA, describing its history, physico-chemical, structural and hydrodynamic properties and biology (occurrence, biosynthesis (by hyaluronan synthases), degradation (by hyaluronidases and oxidative stress), roles, mechanisms of action and receptors). Furthermore, both conventional and recently emerging methods developed for the industrial production of HA and its chemical derivatization are presented. Finally, the medical, pharmaceutical and cosmetic applications of HA and its derivatives are reviewed, reporting examples of HA-based products that currently are on the market or are undergoing further investigations.

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Section: Applications Of Ha and Its Derivativesmentioning

confidence: 99%

Hyaluronic Acid in the Third Millennium

et al. 2018

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“…Using HA hydrogels as tissue analog for stem cells-based therapies are merging as a promising strategy (Loebel et al, 2017 ; Wong et al, 2017 ). Oral administration of HA for the prevention of dry skin was established (Kawada et al, 2015 ; Kimura et al, 2016 ). The use of fragments of HA (35 kDa) was proposed as an additive in infant milk formula promoting intestinal defense (Kessler et al, 2018 ).…”

Section: Ha Products Development Toward New Medical Applicationsmentioning

confidence: 99%

An Effective Translation: The Development of Hyaluronan-Based Medical Products From the Physicochemical, and Preclinical Aspects

Huerta-Ángeles

Nešporová

Ambrožová

et al. 2018

Front. Bioeng. Biotechnol.

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This review shows the steps toward material selection focalized on the design and development of medical devices based on hyaluronan (HA). The selection is based on chemical and mechanical properties, biocompatibility, sterilization, safety, and scale-up costs. These facts play a vital role in the industrialization process. Approved medical devices containing-HA are illustrated to identify key parameters. The first part of this work involves the steps toward a complete characterization of chemical and mechanical aspects, reproducibility of the processes and scale up. In a second stage, we aimed to describe the preclinical in vitro and in vivo assays and selected examples of clinical trials. Furthermore, it is important to keep in mind the regulatory affairs during the research and development (R&D) using standardization (ISO standards) to achieve the main goal, which is the functionality and safety of the final device. To keep reproducible experimental data to prepare an efficient master file for the device, based on quality and recorded manufacturing data, and a rigorous R&D process may help toward clinical translation. A strong debate is still going on because the denominated basic research in HA field does not pay attention to the purity and quality of the raw materials used during the development. So that, to achieve the next generation of devices is needed to overcome the limitations of state of art in terms of efficacy, biodegradability, and non-toxicity.

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“…Similar effects have been reported for hyaluronic acid [19, 20]. Hyaluronic acid is thought to be absorbed after being digested into low molecular weight molecules in the digestive tract by the action of intestinal microbiota [21]. Biokinetic tests have shown it is then delivered to the skin and the knee joints [22, 23].…”

Section: Discussionmentioning

confidence: 70%

Eggshell membrane protein can be absorbed and utilised in the bodies of rats

Matsuoka¹,

Kurihara²,

Yukawa³

et al. 2019

BMC Res Notes

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Objective Eggshell membranes, the thin film lining the insides of eggshells, are constituted mostly from protein (eggshell membrane protein, ESM-P). The digestibility and dietary net protein utility of ESM-P are not known. ESM-P functions as a barrier to prevent foreign matter from reaching the egg white and yolk, so it would be expected not to decompose easily by digestion when ingested. We therefore prepared a hydrolysate of the membrane (ESM-H). In this study, we assessed the digestibility and net protein utility of ESM-P and ESM-H in rats. Results The digestibility of ESM-P and ESM-H were 87.0% and 94.8%, respectively, significantly lower than that of casein (98.5%). The net protein utility values were 84.7% and 84.6%, respectively, significantly higher than that of casein (75.1%). Digestibility was significantly higher for ESM-H than for ESM-P, but there was no significant difference in net protein utility between ESM-P and ESM-H. These results demonstrated that more than 80% of ESM-P or ESM-H is absorbed and utilised in the bodies of rats.

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Absorption of Orally Administered Hyaluronan

Cited by 45 publications

References 34 publications

Hyaluronic Acid in the Third Millennium

Hyaluronic Acid in the Third Millennium

An Effective Translation: The Development of Hyaluronan-Based Medical Products From the Physicochemical, and Preclinical Aspects

Eggshell membrane protein can be absorbed and utilised in the bodies of rats

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