Abstract P3-09-07: Construction of two quality of life questionnaires from young breast cancer patients and their partner

Abstract

Background : The quality of life of couples which one of the members is affected by a cancerous pathology at a relatively young age is important to evaluate in global care. No questionnaire specifically addresses some thematic proper to young women (ex education, desire for a child(s), couple relationship), problems which are yet important for young women suffering from breast cancer. Besides, no questionnaire evaluates the partner's quality of life in this particular context, even if he is frequently the first source of support for the woman (Vanlemmens et al., 2012). Objectives : The main objective was to create a particular and specific tool for measuring the impact of breast cancer on the quality of life of young women (< 45 years of age) with non-metastatic disease and the quality of life of their partners. This work presents the psychometric validation of two questionnaires for patient and partner consisted of items comparable to the semantic level. Methods: We followed the different steps to construct a quality of life tool. After preliminary non-directive interviews and identification of relevant items, we administered the questionnaires on a wide sample of 546 young breast cancer patients and 497 partners. Psychometric testing assessed the hypothesized scale structure based on an examination of item-scale correlation, scale reliability by testing for internal consistency using Cronbach's alpha coefficient, construct validity with inter-scale correlations. Results : Items analyses indicate a good internal consistency of both questionnaires (superior to .75). This questionnaire includes 37 items. The factorial structure highlights 8 factors : 1) management of children and of everyday life, 2) negative affectivity and apprehension about future, 3) feeling of couple cohesion, 4) financial difficulties, 5) body image and sexual life, 6) deterioration with close relations, 7) sharing and support of close relations, and 8) management of the professional life..This structure explains respectively 56% for the patients and 58% for the partners of the total variance. As expected, convergent validity showed strong correlations with Kalicou scales and quality of life measures (QLQC-30 and QLQBR-23). Conclusions: Overall psychometric results for the 2 Kalicou questionnaires confirmed them as valid questionnaires for breast cancer patients and partners. This study will allow the clinicians to have a measurement tool for subjective real-life experience of young breast cancer women and their partner. These questionnaires will also allow comparisons according to the stage and study the interactions of couple. This tool should help to identify modifications of the subjective quality of life. The objective is to improve the medical, psychological and social care for patients and their partner, with a systemic, dynamic approach. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P3-09-07.

Health-related quality of life in women with breast cancer: A review of measures

“…Psychometric properties of twelve PROMs were identi ed: EORTC QLQ-C30, EORTC QLQ-BR23, FACT-B, Functional Assessment of Cancer Therapy-Breast Symptom Index (FBSI), National Comprehensive Cancer Network-Functional Assessment of Cancer Therapy-Breast Cancer Symptom Index-16 (NFBSI-16), Young Women with Breast Cancer Inventory (YW-BCI36), Breast Cancer Symptom Scale (BCSS), QuEST Breast Cancer Questionnaire (QuEST-Br), Quality of Life Instruments for Cancer Patients-Breast Cancer (QLICP-BR), Indonesian Breast Cancer Health-Related Quality of Life (INA-BCHRQoL), and two new unnamed measures [7][8][9]. For each identi ed PROM, Table 2 provides an overview of the measure's purpose, the domains assessed and the number of items.…”

“…The YW-BCI36 [35] and the measure developed by Vanlemmens et al [8,9] were both developed speci cally for women < 45 years old with breast cancer.…”

“…Most of the PROMs assess not only breast cancer symptoms, but the physical and emotional aspects of the disease. Breast cancer-speci c symptoms appear not to be included in INA-BCHRQoL, YW-BCI36, and the new measures [7][8][9]. Physical and emotional or social functioning are included in the QLQ-C30/QLQ-BR23, FACT-B, FBSI, NFBSI-16, QuEST-Br, QLICP-BR, whereas other concepts are addressed within only one or two PROMs.…”

“…For example, sexual function is included in the QLQ-BR23, but no other PROM; body image is only included in the QLQ-BR23 and the YW-BCI36. Vanlemmens and colleagues' measure for young women (<45 years of age) is focused not only on the patient with breast cancer but also on her partner and their relationship (i.e., couple cohesion, managing children/everyday life) [8]. Regarding the nancial impact of living with breast cancer, only the measure by Vanlemmens et al [8] and the YW-BC136 include this concept.…”

“…Vanlemmens et al [8,9] developed and validated a particular and speci c inventory for measuring the impact of breast cancer on the QoL of young women (<45 years of age) with nonmetastatic disease and the QoL of their partners. Reliability (internal consistency and test-retest) has been established.…”