Abuse Potential of Antidepressants

Pagliaro, Louis A.; Pagliaro, Ann Marie

doi:10.2165/00023210-199504040-00001

Cited by 6 publications

(2 citation statements)

References 20 publications

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“…The reported incidence has varied widely (Lejoyeux and Adès, 1997) with no evidence on relationship to dose. Antidepressants in general appear to have little potential for abuse (Pagliaro and Pagliaro, 1995), although case reports suggest that addiction can rarely occur with the dopaminergic antidepressants tranylcypromine and amineptine (Haddad, 1999). There is no evidence that discontinuation reactions are part of a general syndrome of addiction to antidepressants.…”

Section: Stopping Antidepressant Drug Treatmentmentioning

confidence: 99%

Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 1993 British Association for Psychopharmacology guidelines

2000

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A revision of the British Association for Psychopharmacology guidelines for treating depressive disorders with antidepressants was undertaken in order to specify the scope and target of the guidelines and to update the recommendations based explicitly on the available evidence. A consensus meeting, involving experts in depressive disorders and their treatment, reviewed key areas and considered the strength of evidence and clinical implications. The guidelines were drawn up after extensive feedback from participants and interested parties. A literature review is given which identifies the quality of evidence followed by recommendations, the strength of which are based on the level of evidence. The guidelines cover the nature and detection of depressive disorders, acute treatment with antidepressant drugs, choice of drug versus alternative treatment, practical issues in prescribing, management when initial treatment fails, continuation treatment, maintenance treatment to prevent recurrence and stopping treatment.

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Section: Stopping Antidepressant Drug Treatmentmentioning

confidence: 99%

Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 1993 British Association for Psychopharmacology guidelines

2000

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“…Controlled studies with SSRIs and venlafaxine and open studies and case reports with tricyclic antidepressants and MAO inhibitors show that the abrupt suspension of the antidepressant treatment can lead to discontinuation symptoms which occur from the first days up to three weeks. [156][157][158][159] Antidepressants have low potential for abuse 160 and there is no evidence that discontinuation reactions are part of a syndrome of antidepressant addiction. 161…”

Section: One Third Of the Patients With Depressive Episode With Initimentioning

confidence: 99%