AC electrokinetic induced non-Newtonian electrothermal blood flow in 3D microfluidic biosensor with ring electrodes for point-of-care diagnostics

Abstract

Defect-rich GaN interlayer facilitating the annihilation of threading dislocations in polar GaN crystals grown on (0001)-oriented sapphire substrates

Continuous trapping of bacteria in non-Newtonian blood flow using negative dielectrophoresis with quadrupole electrodes

“…To validate the CUDA Fortran code for rheological behavior of non-Newtonian flow, the power-law-based Poiseuille flow is simulated and compared with analytical solutions in our previous published work [17]. With parallel GPU acceleration, the computational speed of the LBM solver is improved by more than 400 times (100 × 100 × 100 nodes) compared with serial simulation using a single CPU thread [17].…”

“…As the ACET flow is a multi-physical phenomenon, its velocity magnitude simultaneously depends on the accuracy of LBM solvers for electric potential, temperature field, and fluid flow. Under this circumstance, to validate the LBM solvers for these multi-physical fields, the vertical Stokes drag force F sty on a suspended particle in ACET flow is calculated [17] and quantitatively compared with the results in Cao et al [53] through setting the same parametric parameters, computational domain geometry, and boundary conditions. As displayed in figure 2, the results computed from the current CUDA Fortran code are consistent with those in reference [53], which validates the accuracy of our LBM solvers.…”

“…In the aforementioned efforts, the ACET phenomenon was always applied to drive the physiological liquid sample in a microfluidic device for point-of-care diagnostics. Specifically, in order to detect bacteria in whole blood using lab-on-a-chip devices, our group designed an ACET blood micropump under various parametric conditions [16], and ring electrodes were used to optimize its pumping efficiency [17]. In contrast the ACET flow of a Newtonian physiological solution, which is almost independent of AC voltage frequency [18], we found that the ACET blood flow exhibits a highly AC-frequency-dependent characteristic, and the shear-thinning rheological behavior of blood also consolidates its pumping efficiency with increasing AC voltage magnitude.…”

“…In addition, the ACET blood flow induced by Joule heating effect could transport bacteria into the DEP-dominant region near the quadrupole electrodes, under which conditions longrange bacteria trapping is realized. Moreover, the whole blood sample could be driven by an ACET micropump as discussed in our previous research [17].…”

AC Electrothermal Effect in Microfluidics: A Review

“…Hong et al developed a coupled model, compared it with the classical model, and found that only at small temperature rises do the results of the two models match [87]. More recently, pumping and mixing of non-Newtonian fluids have been studied [89,90,91].…”