Burnout was finally interpreted, coined as well as defined by Freudenberger in 1961, this concept had and still is being restudied and redefined at every potential moment by various authors and psychologists. However, as there are many journal articles that indicate research about employee burnout, other areas such as student and parental burnout are not studied. Besides the effect of depression, stress is also another prominent negative effect of the student burnout. Thus, the main purpose of this research is to thus interpret and discuss the factors that can potentially influence burnout because one's personality (extraversion, neuroticism, openness to experience, agreeableness, conscientiousness) Therefore data collection was done via various questionnaire which were adopted from previous studies. Two of the paths tested in the structural model were significant with all the t-values greater than critical value of 2.3263 (p-value<0.01). The results indicate that Agreeableness (β =0.402), Neuroticism (β =0.2814) have a significant effect on Burnout. One path was significant with tstatistics greater than the critical value of 1.645 (p-value < 0.05). Openness (β =0.402) has a significant effect on Burnout. Hence H1, H4 and H5 were supported while H2 and H3 were not supported. The implications for prac-tice of this study is that it is recommended for lecturers to differentiate their lec-turing style , taking into consideration the personality orientation of their stu-dents. In summary, the present study provided preliminary evidence on the possible role of personality traits and burnout among university students.