Açaí (Euterpe oleracea Mart.) as a Potential Anti-neuroinflammatory Agent: NLRP3 Priming and Activating Signal Pathway Modulation

Cadoná, Francine Carla; Souza, Diulie Valente de; Fontana, Tuyla; Bodenstein, David; Ramos, Andiara Prates; Sagrillo, Michele Rorato; Salvador, Mirian; Mota, Kennya S.; Davidson, Carolina Bordin; Ribeiro, Euler Esteves; Andreazza, Ana Cristina; Machado, Alencar Kolinski

doi:10.1007/s12035-021-02394-x

Cited by 18 publications

(19 citation statements)

References 75 publications

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“…For example, previous investigations carried out by our research team showed that Rotenone-induced mitochondrial dysfunction could be reversed in the presence of açai extract, an Amazon fruit with antioxidant and anti-inflammatory action [33]. Likewise, açai was able to reverse the inflammatory activation of macrophages [49] and microglia [50]. Other studies have also shown that the inflammatory pattern associated with the VV-SOD2 genotype was attenuated in vitro by supplementing cell cultures with lithium [51].…”

Section: Discussionmentioning

confidence: 65%

Superoxide-imbalance Pharmacologically Induced by Rotenone Triggers Behavioral, Neural, and Inflammatory Alterations in the Eisenia fetida Earthworm

et al. 2022

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Section: Discussionmentioning

confidence: 65%

Superoxide-imbalance Pharmacologically Induced by Rotenone Triggers Behavioral, Neural, and Inflammatory Alterations in the Eisenia fetida Earthworm

et al. 2022

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“…Acai berry extract restored the impairment adonise diphosphate (ATP ) levels in LPS, and nigericin inflammatory inducted microglia (59). In the same study, acai berry extract significantly lowered the pro-apoptotic caspase 1 level to control level (59). Increased levels of pro-apoptotic proteins, such as caspase 1, 3, and 8, were reduced in LPS exposed BV-2 microglia after acai berry extract treatment (58).…”

Section: Calcium Homeostasismentioning

confidence: 79%

“…Mitochondrial damage leads to impaired energy generation, imbalanced calcium concentration, mitochondrial DNA (mtDNA) alteration, increased ROS, and release of pro-apoptotic factors, ultimately resulting in cell death via apoptosis or necrosis (98)(99)(100). Acai berry extract restored the impairment adonise diphosphate (ATP ) levels in LPS, and nigericin inflammatory inducted microglia (59). In the same study, acai berry extract significantly lowered the pro-apoptotic caspase 1 level to control level (59).…”

Section: Calcium Homeostasismentioning

confidence: 88%

“…A study investigating antioxidant activity of different acai berry genotypes and commercial pulp found that all hydroethanolic extracts had a potent scavenging property in reducing ROS produced by hydrogen peroxide (H 2 O 2 ) in the human neuroblastoma SH-SY5Y cell line and no difference in the antioxidant activity was seen between different genotypes by ABTS and deoxyribose assays (51). Moreover, acai berry extract addition resulted in a significant reduction in ROS to the negative control levels in lipopolysaccharide (LPS)activated microglia (58,59). The behavioural analysis revealed that the consumption of commercial acai berry juice could improve neurobehavioral disturbance as a consequence of methylmercury (MeHg) as well as reduced lipid peroxidation and nitrite level induced by MeHg (70).…”

Section: Euterpe Precatoria (Ep) Andmentioning

confidence: 99%

“…A study exploring acai berry regulation of the oxidative/proinflammatory (NF-κB) and anti-oxidative (Nrf2) pathways in DI TNC1 astrocytes showed a reduction of LPS-induced NF-κB activity and induction of the anti-oxidation pathway through Nrf2 and HO-1 expression (62). Moreover, acai berry extract decreased cellular proliferation, IL-1β and restored NO in inflammatory activated microglia (59). Thus, it suggests the vital role of antioxidant-rich acai berry in the regulating and inhibition of the inflammatory response.…”

Section: Euterpe Precatoria (Ep) Andmentioning

confidence: 99%

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Neuroprotective activities of acai berries (Euterpe sp.): A review

ALNasser

Mellor

2022

J Herbmed Pharmacol

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Dietary interventions rich in fruits and vegetables in aging people can reverse or mitigate age-related cognitive declines, delay the onset of neurodegenerative diseases (NDDs), and provide long-term health dividends. The novel food, popularly known as "Acai", is a berry belonging to the Euterpe genus of tropical palms trees and natively found in South America. Euterpe oleracea has been given much attention among scientists due to its high antioxidant capacity compared to other fruits and berries. Additionally, acai pulp composition analysis found that it contains various biologically active phytochemicals. In this review, we focused on current evidence relating to acai berry neuroprotection mechanisms and its efficacy in preventing or reversing neurodegeneration and age-related cognitive decline. A number of studies have illustrated the potential neuroprotective properties of acai berries. They have shown that their chemical extracts have antioxidant and anti-inflammatory properties and maintain proteins, calcium homeostasis, and mitochondrial function. Moreover, acai berry extract offers other neuromodulatory mechanisms, including anticonvulsant, antidepressant, and anti-aging properties. This neuromodulation gives valuable insights into the acai pulp and its considerable pharmacological potential on critical brain areas involved in memory and cognition. The isolated chemical matrix of acai berries could be a new substitute in research for NDD medicine development. However, due to the limited number of investigations, there is a need for further efforts to establish studies that enable progressing to clinical trials to consequently prove and ratify the therapeutic potential of this berry for several incurable NDDs.

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