Acalculous Acute Pancreatitis in a COVID-19 Patient

Meireles, P.; Bessa, Filipe; Gaspar, Pedro; Parreira, Inês; Silva, Virgílio Dias; Mota, Catarina; Alvoeiro, Lourdes

doi:10.12890/2020_001710

Cited by 33 publications

(23 citation statements)

References 4 publications

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“…Evidence suggests that COVID-19 produces pancreatic exocrine cell injury, resulting in pancreatitis ( 6 , 26 – 31 ). We observed that among pancreatic cells, ductal cells exhibited the highest levels of ACE2 and TMPRSS2 coexpression in the same cells and in both sexes.…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 infection of the pancreas promotes thrombofibrosis and is associated with new-onset diabetes

Qadir¹,

Bhondeley²,

Beatty³

et al. 2021

JCI Insight

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Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 infection of the pancreas promotes thrombofibrosis and is associated with new-onset diabetes

Qadir¹,

Bhondeley²,

Beatty³

et al. 2021

JCI Insight

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“…Meireles et al [ 23 ] described the case of a 36-year-old black woman with SARS-CoV-2 pneumonia, with dry cough, breathlessness, and fever for 4 d. During supplemental oxygen therapy for pneumonia, on day 7 (day 11 of disease), nausea, vomiting, and epigastric pain were reported, with no fever or other physical signs but with increased levels of amylase and lipase in blood tests. Supportive therapy was used, and clinical, laboratory, and radiological improvement was achieved (with no pancreatic pathology in CT on day 3)[ 23 ].…”

Section: Case Reports and Cohort Studies On Ap In Covid-19 In The Literature Searchmentioning

confidence: 99%

Association between acute pancreatitis and COVID-19 infection: What do we know?

Jabłońska

Mrowiec

2021

WJGS

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The disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also called coronavirus disease 2019 (COVID-19), first originated in Wuhan, China, displaying atypical pneumonia-like respiratory symptoms in affected patients. SARS-CoV-2 primarily attacks the respiratory system, and the most common symptoms include cough, shortness of breath, and fever. However, its impact on the digestive system has been shown, and various clinical gastrointestinal manifestations of this disease have been recognized. Some reports have shown acute pancreatitis (AP) as the initial symptom in patients with COVID-19. AP may be a consequence of direct pancreatic damage by the virus because pancreatic acinar cells contain angiotensin-converting enzyme 2 receptor proteins, and SARS-CoV-2 can bind to these receptors, causing pancreatic injury. Moreover, AP may be a secondary indicator of cytokine storms and altered inflammatory responses. Our review of the literature shows that SARS-CoV-2 appears to be a new etiological infectious factor related to AP. In this manuscript, a comprehensive review of case reports and case series of patients with AP and COVID-19 is presented. All reports on COVID-19-associated AP are summarized. All cases are thoroughly analyzed and discussed in-depth.

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“…To the best of our knowledge, no case of necrotizing pancreatitis in the setting of COVID-19 has been reported so far. Considering the possible occurrence of mild pancreatic injury in patients with COVID-19 pneumonia, it may be prudent to evaluate pancreatic enzymes in patients presenting with GI symptoms[ 56 ]. CT imaging could be used in conjunction with the clinical parameters in order to establish a correct diagnosis or provide an alternative diagnosis when in doubt.…”

Section: Pancreatic Involvementmentioning

confidence: 99%

Imaging spectrum of abdominal manifestations of COVID-19

Vaidya¹,

Nanivadekar²,

Patel³

2021

WJR

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Coronavirus disease 2019 (COVID-19) has posed a serious threat to global public health with its rapid spread, high fatality, and severe burden on health care providers all over the world. Although COVID-19 has been established as a respiratory tract infection, it can manifest with gastrointestinal symptoms as a consequence of direct infection by the virus or due to inflammation-mediated cytotoxicity. It has been observed that COVID-19 patients presenting with gastrointestinal symptoms tend to progress to a severe form of disease with increased morbidity and mortality, thus indicating the need for timely management. COVID-19 manifests with a wide spectrum of radiologic findings on gastrointestinal tract imaging, encompassing bowel abnormalities, hepato-biliary and pancreatic involvement, vascular occlusion, and solid organ infarction. Early recognition of these imaging features can facilitate timely treatment of COVID-19 associated gastrointestinal tract complications and may prompt the diagnosis of COVID-19 in patients with atypical disease manifestations. The aim of this article is to provide an overview of the various gastrointestinal imaging manifestations that can be encountered in patients with COVID-19, with an emphasis on early diagnosis of the disease as well as treatment related complications.

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Acalculous Acute Pancreatitis in a COVID-19 Patient

Cited by 33 publications

References 4 publications

SARS-CoV-2 infection of the pancreas promotes thrombofibrosis and is associated with new-onset diabetes

SARS-CoV-2 infection of the pancreas promotes thrombofibrosis and is associated with new-onset diabetes

Association between acute pancreatitis and COVID-19 infection: What do we know?

Imaging spectrum of abdominal manifestations of COVID-19

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